Detalhe da pesquisa
1.
Protein-Templated Ugi Reactions versus In-Situ Ligation Screening: Two Roads to the Identification of SARS-CoV-2 Main Protease Inhibitors.
Chemistry
; 30(17): e202303940, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38246870
2.
A Formylglycine-Peptide for the Site-Directed Identification of Phosphotyrosine-Mimetic Fragments.
Chemistry
; 28(57): e202201282, 2022 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35781901
3.
Chemical Evolution of Antivirals Against Enterovirus D68 through Protein-Templated Knoevenagel Reactions.
Angew Chem Int Ed Engl
; 60(24): 13294-13301, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33749121
4.
Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.
Angew Chem Int Ed Engl
; 56(26): 7358-7378, 2017 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28117936
5.
Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins.
Nat Commun
; 15(1): 3537, 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670939
6.
A Critical Study on Acylating and Covalent Reversible Fragment Inhibitors of SARS-CoV-2 Main Protease Targeting the S1 Site with Pyridine.
ChemMedChem
; 18(9): e202200635, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812048
7.
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-ß-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems.
J Med Chem
; 66(17): 11761-11791, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37585683
8.
High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.
BMC Biotechnol
; 12: 56, 2012 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22916876
9.
Nanoparticular Inhibitors of Flavivirus Proteases from Zika, West Nile and Dengue Virus Are Cell-Permeable Antivirals.
ACS Med Chem Lett
; 12(12): 1955-1961, 2021 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34917260
10.
Catching a Moving Target: Comparative Modeling of Flaviviral NS2B-NS3 Reveals Small Molecule Zika Protease Inhibitors.
ACS Med Chem Lett
; 11(4): 514-520, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292558
11.
Use of IHC and newly designed matriptase inhibitors to elucidate the role of matriptase in pancreatic ductal adenocarcinoma.
Int J Oncol
; 35(2): 347-57, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19578749
12.
The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation.
Nat Commun
; 10(1): 66, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622248
13.
Author Correction: Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins.
Nat Commun
; 15(1): 4323, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38773122
14.
Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.
Angew Chem Int Ed Engl
; 52(32): 8210-2, 2013 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23794491
15.
Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases.
J Med Chem
; 61(3): 1218-1230, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29328649
16.
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments.
Nat Commun
; 7: 12761, 2016 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27677239
17.
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells inâ vitro and inâ vivo.
ChemMedChem
; 10(5): 815-26, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25877780
18.
Proteintemplat-gesteuerte Fragmentligationen - von der molekularen Erkennung zur Wirkstofffindung.
Angew Chem Weinheim Bergstr Ger
; 129(26): 7464-7485, 2017 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32313319
19.
Synthesis and functional characterization of tridegin and its analogues: inhibitors and substrates of factor XIIIa.
ChemMedChem
; 7(2): 326-33, 2012 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22162181