Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Proprotein convertase activation of aggrecanases in cartilage in situ.

Malfait, Anne-Marie; Arner, Elizabeth C; Song, Ruo-Hua; Alston, James T; Markosyan, Stella; Staten, Nicholas; Yang, Zhiyong; Griggs, David W; Tortorella, Micky D.

Arch Biochem Biophys ; 478(1): 43-51, 2008 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-18671934

2.

Aggrecanase-mediated cartilage degradation.

Arner, Elizabeth C.

Curr Opin Pharmacol ; 2(3): 322-9, 2002 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-12020478

3.

ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).

Zack, Marc D; Malfait, Anne-Marie; Skepner, Adam P; Yates, Matthew P; Griggs, David W; Hall, Troii; Hills, Robert L; Alston, James T; Nemirovskiy, Olga V; Radabaugh, Melissa R; Leone, Joseph W; Arner, Elizabeth C; Tortorella, Micky D.

Arthritis Rheum ; 60(9): 2704-13, 2009 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-19714641

4.

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).

Shieh, Huey-Sheng; Mathis, Karl J; Williams, Jennifer M; Hills, Robert L; Wiese, Joe F; Benson, Timothy E; Kiefer, James R; Marino, Margaret H; Carroll, Jeffery N; Leone, Joseph W; Malfait, Anne-Marie; Arner, Elizabeth C; Tortorella, Micky D; Tomasselli, Alfredo.

J Biol Chem ; 283(3): 1501-1507, 2008 Jan 18.

Artigo em Inglês | MEDLINE | ID: mdl-17991750

5.

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

Song, Ruo-Hua; Tortorella, Micky D; Malfait, Anne-Marie; Alston, James T; Yang, Zhiyong; Arner, Elizabeth C; Griggs, David W.

Arthritis Rheum ; 56(2): 575-85, 2007 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-17265492

6.

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

Wittwer, Arthur J; Hills, Robert L; Keith, Robert H; Munie, Grace E; Arner, Elizabeth C; Anglin, Charles P; Malfait, Anne-Marie; Tortorella, Micky D.

Biochemistry ; 46(21): 6393-401, 2007 May 29.

Artigo em Inglês | MEDLINE | ID: mdl-17487981

7.

Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.

Hills, Robert; Mazzarella, Richard; Fok, Kam; Liu, Min; Nemirovskiy, Olga; Leone, Joseph; Zack, Marc D; Arner, Elizabeth C; Viswanathan, Malini; Abujoub, Aida; Muruganandam, Arumugam; Sexton, Daniel J; Bassill, Gary J; Sato, Aaron K; Malfait, Anne-Marie; Tortorella, Micky D.

J Biol Chem ; 282(15): 11101-9, 2007 Apr 13.

Artigo em Inglês | MEDLINE | ID: mdl-17311924

8.

Identification of fibronectin neoepitopes present in human osteoarthritic cartilage.

Zack, Marc D; Arner, Elizabeth C; Anglin, Charles P; Alston, James T; Malfait, Anne-Marie; Tortorella, Micky D.

Arthritis Rheum ; 54(9): 2912-22, 2006 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-16948117

9.

ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.

Tortorella, Micky D; Arner, Elizabeth C; Hills, Robert; Gormley, Jennifer; Fok, Kam; Pegg, Lyle; Munie, Grace; Malfait, Anne-Marie.

Arch Biochem Biophys ; 444(1): 34-44, 2005 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-16289022

10.

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.

Wang, Ping; Tortorella, Micky; England, Kristen; Malfait, Anne-Marie; Thomas, Gary; Arner, Elizabeth C; Pei, Duanqing.

J Biol Chem ; 279(15): 15434-40, 2004 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-14744861

11.

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.

Tortorella, Micky D; Arner, Elizabeth C; Hills, Robert; Easton, Alan; Korte-Sarfaty, Jennifer; Fok, Kam; Wittwer, Arthur J; Liu, Rui-Qin; Malfait, Anne-Marie.

J Biol Chem ; 279(17): 17554-61, 2004 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-14715656

12.

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

Yamanishi, Yuji; Boyle, David L; Clark, Melody; Maki, Rich A; Tortorella, Micky D; Arner, Elizabeth C; Firestein, Gary S.

J Immunol ; 168(3): 1405-12, 2002 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-11801682

13.

Aggrecan protects cartilage collagen from proteolytic cleavage.

Pratta, Michael A; Yao, Wenqing; Decicco, Carl; Tortorella, Micky D; Liu, Riu-Qin; Copeland, Robert A; Magolda, Ronald; Newton, Robert C; Trzaskos, James M; Arner, Elizabeth C.

J Biol Chem ; 278(46): 45539-45, 2003 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-12890681

14.

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.

Cherney, Robert J; Mo, Ruowei; Meyer, Dayton T; Wang, Li; Yao, Wenqing; Wasserman, Zelda R; Liu, Rui-Qin; Covington, Maryanne B; Tortorella, Micky D; Arner, Elizabeth C; Qian, Mingxin; Christ, David D; Trzaskos, James M; Newton, Robert C; Magolda, Ron L; Decicco, Carl P.

Bioorg Med Chem Lett ; 13(7): 1297-300, 2003 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-12657268

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