1.
Chem Commun (Camb)
; 51(16): 3379-82, 2015 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25622147
RESUMO
A copper-catalyzed regio- and intermolecular aminofluorination of styrenes has been developed. In this reaction Ph-I=N-Ts and Et3N·3HF act as nitrogen and fluorine sources, respectively. The obtained ß-fluoro-N-Ts-phenethylamines can be N-alkylated with subsequent deprotection affording the corresponding ß-fluoro-N-alkylated phenethylamines, which are interesting building blocks for compounds acting on neuronal targets.