Detalhe da pesquisa
1.
Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition.
Chemistry
; : e202400723, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38623783
2.
Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.
J Lipid Res
; 63(5): 100199, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35315333
3.
1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease.
J Am Chem Soc
; 144(32): 14819-14827, 2022 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35917590
4.
Human glucocerebrosidase mediates formation of xylosyl-cholesterol by ß-xylosidase and transxylosidase reactions.
J Lipid Res
; 62: 100018, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33361282
5.
Activity-Based Protein Profiling of Retaining α-Amylases in Complex Biological Samples.
J Am Chem Soc
; 143(5): 2423-2432, 2021 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33497208
6.
Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase.
Chembiochem
; 22(21): 3090-3098, 2021 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459538
7.
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.
Chemistry
; 27(66): 16377-16388, 2021 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34570911
8.
Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent ß-l-Arabinofuranosidase Inhibitor.
Angew Chem Int Ed Engl
; 60(11): 5754-5758, 2021 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33528085
9.
Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases.
J Am Chem Soc
; 142(10): 4648-4662, 2020 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32053363
10.
Role of ß-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish.
J Lipid Res
; 60(11): 1851-1867, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31562193
11.
Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease.
J Biol Chem
; 293(26): 10042-10058, 2018 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29674318
12.
Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.
J Am Chem Soc
; 141(10): 4214-4218, 2019 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30811188
13.
Activity-based probes for functional interrogation of retaining ß-glucuronidases.
Nat Chem Biol
; 13(8): 867-873, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28581485
14.
Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors.
European J Org Chem
; 2019(6): 1397-1404, 2019 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31787842
15.
Distinguishing the differences in ß-glycosylceramidase folds, dynamics, and actions informs therapeutic uses.
J Lipid Res
; 59(12): 2262-2276, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30279220
16.
Gluco-1 H-imidazole: A New Class of Azole-Type ß-Glucosidase Inhibitor.
J Am Chem Soc
; 140(15): 5045-5048, 2018 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29601200
17.
Corrigendum: Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase.
Chembiochem
; 24(3): e202300728, 2023 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36725348
18.
New Irreversible α-l-Iduronidase Inhibitors and Activity-Based Probes.
Chemistry
; 24(71): 19081-19088, 2018 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30307091
19.
Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.
J Am Chem Soc
; 139(19): 6534-6537, 2017 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28463498
20.
Corrigendum: Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase.
Chembiochem
; : e202200728, 2022 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36581583