Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Crosstalk between metabolism and circadian clocks.

Reinke, Hans; Asher, Gad.

Nat Rev Mol Cell Biol ; 20(4): 227-241, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30635659

2.

Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock.

Asher, Gad; Sassone-Corsi, Paolo.

Cell ; 161(1): 84-92, 2015 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-25815987

3.

Carbon dioxide regulates cholesterol levels through SREBP2.

Bolshette, Nityanand; Ezagouri, Saar; Dandavate, Vaishnavi; Karavaeva, Iuliia; Golik, Marina; Wang, Hu; Espenshade, Peter J; Osborne, Timothy F; Han, Xianlin; Asher, Gad.

PLoS Biol ; 21(11): e3002367, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37967106

4.

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding.

Asher, Gad; Reinke, Hans; Altmeyer, Matthias; Gutierrez-Arcelus, Maria; Hottiger, Michael O; Schibler, Ueli.

Cell ; 142(6): 943-53, 2010 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-20832105

5.

Input integration by the circadian clock exhibits nonadditivity and fold-change detection.

Manella, Gal; Bolshette, Nityanand; Golik, Marina; Asher, Gad.

Proc Natl Acad Sci U S A ; 119(44): e2209933119, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36279450

6.

Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions.

Asher, Gad; Zhu, Bokai.

Hepatology ; 77(3): 1022-1035, 2023 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-35591797

7.

Ultradian rhythms of AKT phosphorylation and gene expression emerge in the absence of the circadian clock components Per1 and Per2.

Aviram, Rona; Dandavate, Vaishnavi; Manella, Gal; Golik, Marina; Asher, Gad.

PLoS Biol ; 19(12): e3001492, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34968386

8.

Lipidomics Analyses Reveal Temporal and Spatial Lipid Organization and Uncover Daily Oscillations in Intracellular Organelles.

Aviram, Rona; Manella, Gal; Kopelman, Naama; Neufeld-Cohen, Adi; Zwighaft, Ziv; Elimelech, Meytar; Adamovich, Yaarit; Golik, Marina; Wang, Chunyan; Han, Xianlin; Asher, Gad.

Mol Cell ; 62(4): 636-48, 2016 05 19.

Artigo em Inglês | MEDLINE | ID: mdl-27161994

9.

Clock proteins and training modify exercise capacity in a daytime-dependent manner.

Adamovich, Yaarit; Dandavate, Vaishnavi; Ezagouri, Saar; Manella, Gal; Zwighaft, Ziv; Sobel, Jonathan; Kuperman, Yael; Golik, Marina; Auerbach, Asher; Itkin, Maxim; Malitsky, Sergey; Asher, Gad.

Proc Natl Acad Sci U S A ; 118(35)2021 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-34426495

10.

SIRT1 regulates circadian clock gene expression through PER2 deacetylation.

Asher, Gad; Gatfield, David; Stratmann, Markus; Reinke, Hans; Dibner, Charna; Kreppel, Florian; Mostoslavsky, Raul; Alt, Frederick W; Schibler, Ueli.

Cell ; 134(2): 317-28, 2008 Jul 25.

Artigo em Inglês | MEDLINE | ID: mdl-18662546

11.

Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment.

Manella, Gal; Aviram, Rona; Bolshette, Nityanand; Muvkadi, Sapir; Golik, Marina; Smith, David F; Asher, Gad.

Proc Natl Acad Sci U S A ; 117(1): 779-786, 2020 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-31848250

12.

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins.

Neufeld-Cohen, Adi; Robles, Maria S; Aviram, Rona; Manella, Gal; Adamovich, Yaarit; Ladeuix, Benjamin; Nir, Dana; Rousso-Noori, Liat; Kuperman, Yael; Golik, Marina; Mann, Matthias; Asher, Gad.

Proc Natl Acad Sci U S A ; 113(12): E1673-82, 2016 Mar 22.

Artigo em Inglês | MEDLINE | ID: mdl-26862173

13.

Circadian Clock Control of Liver Metabolic Functions.

Reinke, Hans; Asher, Gad.

Gastroenterology ; 150(3): 574-80, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26657326

14.

The emerging roles of lipids in circadian control.

Adamovich, Yaarit; Aviram, Rona; Asher, Gad.

Biochim Biophys Acta ; 1851(8): 1017-25, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-25483623

15.

The liver by day and by night.

Aviram, Rona; Manella, Gal; Asher, Gad.

J Hepatol ; 74(5): 1240-1242, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33741205

16.

The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactions.

Shalev, Moran; Aviram, Rona; Adamovich, Yaarit; Kraut-Cohen, Judith; Shamia, Tal; Ben-Dor, Shifra; Golik, Marina; Asher, Gad.

Nucleic Acids Res ; 42(19): 11879-90, 2014 Oct 29.

Artigo em Inglês | MEDLINE | ID: mdl-25260595

17.

The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactions.

Shalev, Moran; Aviram, Rona; Adamovich, Yaarit; Kraut-Cohen, Judith; Shamia, Tal; Ben-Dor, Shifra; Golik, Marina; Asher, Gad.

Nucleic Acids Res ; 46(14): 7469-7470, 2018 08 21.

Artigo em Inglês | MEDLINE | ID: mdl-29982772

18.

Liver size: Waning by day, Waxing by Night.

Reinke, Hans; Asher, Gad.

Hepatology ; 67(1): 441-443, 2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-28873232

19.

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology.

Bolshette, Nityanand; Ibrahim, Hussam; Reinke, Hans; Asher, Gad.

Nat Rev Gastroenterol Hepatol ; 20(11): 695-707, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37291279

20.

Circadian clocks' interactions with oxygen sensing and signalling.

Adamovich, Yaarit; Dandavate, Vaishnavi; Asher, Gad.

Acta Physiol (Oxf) ; 234(2): e13770, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34984824

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Crosstalk between metabolism and circadian clocks.

Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock.

Carbon dioxide regulates cholesterol levels through SREBP2.

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding.

Input integration by the circadian clock exhibits nonadditivity and fold-change detection.

Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions.

Ultradian rhythms of AKT phosphorylation and gene expression emerge in the absence of the circadian clock components Per1 and Per2.

Lipidomics Analyses Reveal Temporal and Spatial Lipid Organization and Uncover Daily Oscillations in Intracellular Organelles.

Clock proteins and training modify exercise capacity in a daytime-dependent manner.

SIRT1 regulates circadian clock gene expression through PER2 deacetylation.

Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment.

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins.

Circadian Clock Control of Liver Metabolic Functions.

The emerging roles of lipids in circadian control.

The liver by day and by night.

The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactions.

The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactions.

Liver size: Waning by day, Waxing by Night.

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology.

Circadian clocks' interactions with oxygen sensing and signalling.