Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.

Pio, Barbara; Chobanian, Harry R; Guo, Yan; Josien, Hubert; Hagmann, William K; Miller, Michael; Trujillo, Maria E; Kirkland, Melissa; Kosinski, Daniel; Mane, Joel; Pachanski, Michele; Cheewatrakoolpong, Boonlert; Ashley, Eric; Orr, Robert; Wright, Michael J; Bugianesi, Randal; Souza, Sarah; Zhang, Xiaoping; Di Salvo, Jerry; Weinglass, Adam B; Tschirret-Guth, Richard; Samuel, Koppara; Chen, Qing; Shang, Jackie; Lamca, James; Ehrhart, Juliann; Nargund, Ravi; Howard, Andrew D; Colletti, Steven L.

Bioorg Med Chem Lett ; 29(14): 1842-1848, 2019 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-31109791

2.

Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether.

Kuethe, Jeffrey T; Basu, Kallol; Orr, Robert K; Ashley, Eric; Poirier, Marc; Tan, Lushi.

Bioorg Med Chem ; 26(4): 938-944, 2018 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-28751197

3.

Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes.

Palani, Anandan; Nawrocki, Andrea R; Orvieto, Federica; Bianchi, Elisabetta; Mandic, Emanuela; Pessi, Antonello; Huang, Chunhui; Deng, Qiaolin; Toussaint, Nathalie; Walsh, Erika; Reddy, Vijay; Ashley, Eric; He, Huaibing; Mumick, Sheena; Hawes, Brian; Marsh, Donald; Erion, Mark; Nargund, Ravi; Carrington, Paul E.

ACS Med Chem Lett ; 13(8): 1248-1254, 2022 Aug 11.

Artigo em Inglês | MEDLINE | ID: mdl-35978682

4.

Scalable Preparation of 4,4-Disubstituted Six-Membered Cyclic Sulfones.

Hugelshofer, Cedric L; Bao, Jianming; Du, Juana; Ashley, Eric; Yu, Wensheng; Ji, Tao; Hu, Bin; Liu, Dejun; Rondla, Ramu; Karampuri, Srinivas; Sharma, Vishal; Ethiraj, Krishna; Lim, Yeon-Hee.

Org Lett ; 23(3): 943-947, 2021 02 05.

Artigo em Inglês | MEDLINE | ID: mdl-33417467

5.

Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents.

Adams, Gregory L; Velazquez, Francisco; Jayne, Charles; Shah, Unmesh; Miao, Shouwu; Ashley, Eric R; Madeira, Maria; Akiyama, Taro E; Di Salvo, Jerry; Suzuki, Takao; Wang, Nengxue; Truong, Quang; Gilbert, Eric; Zhou, Dan; Verras, Andreas; Kirkland, Melissa; Pachanski, Michele; Powles, Maryann; Yin, Wu; Ujjainwalla, Feroze; Venkatraman, Srikanth; Edmondson, Scott D.

ACS Med Chem Lett ; 8(1): 96-101, 2017 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-28105282

6.

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.

Cox, Jason M; Chu, Hong D; Chelliah, Mariappan V; Debenham, John S; Eagen, Keith; Lan, Ping; Lombardo, Matthew; London, Clare; Plotkin, Michael A; Shah, Unmesh; Sun, Zhongxiang; Vaccaro, Henry M; Venkatraman, Srikanth; Suzuki, Takao; Wang, Nengxue; Ashley, Eric R; Crespo, Alejandro; Madeira, Maria; Leung, Dennis H; Alleyne, Candice; Ogawa, Aimie M; Souza, Sarah; Thomas-Fowlkes, Brande; Di Salvo, Jerry; Weinglass, Adam; Kirkland, Melissa; Pachanski, Michele; Powles, Mary Ann; Tozzo, Effie; Akiyama, Taro E; Ujjainwalla, Feroze; Tata, James R; Sinz, Christopher J.

ACS Med Chem Lett ; 8(1): 49-54, 2017 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-28105274

7.

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.

Hyde, Alan M; Liu, Zhijian; Kosjek, Birgit; Tan, Lushi; Klapars, Artis; Ashley, Eric R; Zhong, Yong-Li; Alvizo, Oscar; Agard, Nicholas J; Liu, Guiquan; Gu, Xiuyan; Yasuda, Nobuyoshi; Limanto, John; Huffman, Mark A; Tschaen, David M.

Org Lett ; 18(22): 5888-5891, 2016 11 18.

Artigo em Inglês | MEDLINE | ID: mdl-27802043

8.

Ailing and failing endosseous dental implants: a literature review.

Ashley, Eric T; Covington, Lemuel L; Bishop, Barry G; Breault, Lawrence G.

J Contemp Dent Pract ; 4(2): 35-50, 2003 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-12761588

9.

A highly efficient asymmetric synthesis of vernakalant.

Limanto, John; Ashley, Eric R; Yin, Jingjun; Beutner, Gregory L; Grau, Brendan T; Kassim, Amude M; Kim, Mary M; Klapars, Artis; Liu, Zhijian; Strotman, Hallena R; Truppo, Matthew D.

Org Lett ; 16(10): 2716-9, 2014 May 16.

Artigo em Inglês | MEDLINE | ID: mdl-24786635

10.

The total synthesis of (--)-lemonomycin.

Ashley, Eric R; Cruz, Ernest G; Stoltz, Brian M.

J Am Chem Soc ; 125(49): 15000-1, 2003 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-14653730

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