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BACKGROUND AND AIMS: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. METHODS: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. RESULTS: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54-7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11-4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08-10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80-5.38). CONCLUSIONS: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).
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Dor Crônica , Pancreatite Crônica , Humanos , Estudos Longitudinais , Dor Crônica/epidemiologia , Pancreatite Crônica/complicações , Pancreatite Crônica/epidemiologia , Saúde Mental , Medidas de Resultados Relatados pelo Paciente , Qualidade de VidaRESUMO
BACKGROUND: Early detection is necessary for the treatment of dementia. Computerized testing has become more widely used in clinical trials; however, it is unclear how sensitive these measures are to early signs of neurodegeneration. We investigated the use of the NIH Toolbox-Cognition (NIHTB-CB) and Cogstate-Brief computerized neuropsychological batteries in the identification of mild cognitive impairment (MCI) versus healthy older adults [healthy control (HC)] and amnestic (aMCI) versus nonamnestic MCI (naMCI). Exploratory analyses include investigating potential racial differences. METHODS: Two hundred six older adults were diagnosed as aMCI (n = 58), naMCI (n = 15), or cognitively healthy (HC; n = 133). RESULTS: The NIH Toolbox-CB subtests of Flanker, Picture Sequence Memory, and Picture Vocabulary significantly differentiated MCI from HC. Further, subtests from both computerized batteries differentiated patients with aMCI from those with naMCI. Although the main effect of race differences was noted on tests and in diagnostic groups was significant, there were no significant race-by-test interactions. CONCLUSIONS: Computer-based subtests vary in their ability to help distinguish MCI subtypes, though these tests provide less expensive and easier-to-administer clinical screeners to help identify patients early who may qualify for more comprehensive evaluations. Further work is needed, however, to refine computerized tests to achieve better precision in distinguishing impairment subtypes.
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Amnésia , Disfunção Cognitiva , Humanos , Idoso , Amnésia/diagnóstico , Disfunção Cognitiva/diagnóstico , Disfunção Cognitiva/psicologia , Cognição , Testes NeuropsicológicosRESUMO
Skilled adult readers vary in many skills related to visual word form processing such as phonological processing, vocabulary size, comprehension skill, and spelling skill (Kuperman & Van Dyke, 2011). Spelling skill in particular has received much attention because low- and high-skill spellers show different patterns of lexical processing as measured through eye movement behavior, reaction times, and word learning (Eskenazi et al., 2018; Veldre & Andrews, 2014). Researchers commonly use a spelling dictation task to measure lexical expertise; however, there is limited evidence for its psychometric properties and room for improvement in item selection (Andrews et al., 2020). The purpose of this study was to assess the precision of 110 words as measures of lexical expertise, to compare various subsets of words in a spelling dictation task, and to provide a set of words that more precisely measure lexical expertise. In Study 1, a spelling dictation task with 110 words was administered to 682 participants. In Study 2, that same task and measures of vocabulary and comprehension were administered to 786 participants. Results indicated that the set of 110 words contains many words that are imprecise measures of spelling skill. Through an iterative process of removing words with high error variance, a set of 20 words was selected that minimizes measurement error and demonstrates discriminant validity from vocabulary and comprehension ability. We recommend this set of words as a more precise measure of spelling skill, which will provide more power to detect moderating effects of lexical expertise on reading processes.
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Idioma , Vocabulário , Adulto , Humanos , Leitura , Linguística , CompreensãoRESUMO
OBJECTIVE: To evaluate test-retest reliability and related measurement properties of items developed to assess best, worst, and average prosthetic socket comfort. DESIGN: Methodological research to assess test-retest reliability of 4 individual socket comfort survey items. Socket comfort items were included in a self-report paper survey, which was administered to participants 2 to 3 days apart. SETTING: General community. PARTICIPANTS: A minimum convenience sample of participants (N=63) was targeted for this study; 72 lower limb prosthesis users (>1y postamputation) completed the survey and were included in the final dataset. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: The expanded socket comfort score (ESCS) was adapted from the original socket comfort score (SCS). The original SCS is a single-item self-report instrument developed to assess a lower limb prosthesis user's current socket comfort. Three additional items were designed to assess the user's best, worst, and average socket comfort over the previous 7 days. RESULTS: Best, worst, and average socket comfort items demonstrated better reliability, as indicated by higher intraclass correlation coefficients. As such, these items also exhibited lower measurement error and smaller minimal detectable change values than the item that measured current socket comfort. However, test-retest coefficients for all 4 ESCS items were below the level desired for evaluation of within-individual changes of socket comfort. CONCLUSIONS: Items that assess best, worst, and average comfort provide a more stable measurement of socket fit than the existing SCS instrument. Although administration of all 4 ESCS items may provide more comprehensive assessment of a lower limb prosthesis user's socket fit, administrators should expect variations in scores over time owing to the variable nature of the underlying construct over time. Future research should examine whether the ESCS provides an improved overall assessment of socket fit.
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Amputados , Membros Artificiais , Humanos , Desenho de Prótese , Reprodutibilidade dos Testes , Autorrelato , Inquéritos e QuestionáriosRESUMO
While regular exercise is associated with a number of physical and mental health benefits, basing one's self-esteem largely on exercise is likely associated with negative outcomes. In the present studies, the authors developed a novel measure of this construct, something they term "exercise overvaluation." In Study 1, 820 participants completed an online survey measuring self-esteem, exercise attitudes and behaviors, and eating disorder symptoms. Exploratory and confirmatory factor analysis were employed to develop the 14-item Exercise Overvaluation Scale. The results provided evidence of discriminant and convergent validity and internal consistency reliability of scale scores. In Study 2, the Exercise Overvaluation Scale was administered to 134 university athletes, including those who participated in intramural sports, club sports, and collegiate athletics. The results from Study 2 supported the criterion validity and test-retest reliability of scale scores. This scale offers researchers a new tool to help understand the relationships among exercise, self-esteem, and physical and mental health outcomes.
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Exercício Físico , Análise Fatorial , Humanos , Psicometria , Reprodutibilidade dos Testes , Inquéritos e QuestionáriosRESUMO
INTRODUCTION: We aimed to describe the physical and cognitive health of patients with differing levels of post-stroke disability, as defined by modified Rankin Scale (mRS) scores. We also compared cross-sectional correlations between the mRS and the Quality of Life in Neurological Disorders (Neuro-QoL) T-scores to longitudinal correlations of change estimates from each measure. METHODS: Mean Neuro-QoL T-scores representing mobility, dexterity, executive function, and cognitive concerns were compared among mRS subgroups. Fixed-effects regression models with robust standard errors estimated correlations among mRS and Neuro-QoL domain scores and correlations among longitudinal change estimates. These change estimates were then compared to distribution-based estimates of minimal clinically important differences. RESULTS: Seven hundred forty-five patients with ischemic stroke (79%) or transient ischemic attack (21%) were enrolled in this longitudinal observational study of post-stroke outcomes. Larger differences in cognitive function were observed in the severe mRS groups (ie, 4-5) while larger differences in physical function were observed in the mild-moderate mRS groups (ie, 0-2). Cross-sectional correlations among mRS and Neuro-QoL T-scores were high (r = 0.61-0.83), but correlations among longitudinal change estimates were weak (r = 0.14-0.44). CONCLUSIONS: Findings from this study undermine the validity and utility of the mRS as an outcome measure in longitudinal studies in ischemic stroke patients. Nevertheless, strong correlations indicate that the mRS score, obtained with a single interview, is efficient at capturing important differences in patient-reported quality of life, and is useful for identifying meaningful cross-sectional differences among clinical subgroups.
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Transtornos Cognitivos/diagnóstico , Ataque Isquêmico Transitório/diagnóstico , AVC Isquêmico/diagnóstico , Doenças do Sistema Nervoso/diagnóstico , Testes Neuropsicológicos , Qualidade de Vida , Idoso , Transtornos Cognitivos/psicologia , Estudos Transversais , Feminino , Humanos , Ataque Isquêmico Transitório/psicologia , Ataque Isquêmico Transitório/terapia , AVC Isquêmico/psicologia , AVC Isquêmico/terapia , Estudos Longitudinais , Masculino , Doenças do Sistema Nervoso/psicologia , Testes Neuropsicológicos/normas , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/diagnóstico , Resultado do TratamentoRESUMO
OBJECTIVE: To assess the effect of time to acute therapy on health-related quality of life (HRQoL) and disability after ischemic stroke. DESIGN: Prospective cohort study. SETTING: Comprehensive stroke care center in a large metropolitan city. PARTICIPANTS: Patients (N=553; mean age, 67 y; 51.9% male; 64.4% white; 88.8% ischemic stroke) with ischemic stroke or transient ischemic attack (TIA) enrolled in a longitudinal observational study between August 2012 to January 2014 who received rehabilitation services. INTERVENTION: Not applicable. MAIN OUTCOME MEASURES: Disability status was assessed with the modified Rankin Scale (mRS) and Barthel Index (BI). HRQoL was assessed using the Quality of Life in Neurological Disorders measures of executive function, general cognitive concerns, upper extremity dexterity, and lower extremity mobility. Time to therapy consult and treatment were defined as the number of days from hospital admission to initial consult by a therapist and number of days from hospital admission to initial treatment, respectively. RESULTS: Among the participants, the median number of days from hospital admission to acute therapy consult was 2 days (interquartile range, 1-3d). Multivariable linear and logistic regression models indicated that for those with the National Institutes of Health Stroke Scale (NIHSS) score<5, longer time to therapy consult was associated with worse BI scores (BI=100; odds ratio [OR], 0.818; P=.008), executive function T scores (b=-0.865; P=.001), and general cognitive concerns T scores (b=-0.609; P=.009) at 1-month in adjusted analyses. In those with NIHSS score≥5, longer time to therapy treatment led to increased disability (ie, mRS≥ 2; OR, 1.15; P=.039) and lower extremity mobility T scores (b=-0.591; P=.046) at 1 month in adjusted analyses. CONCLUSIONS: Longer time to initiation of acute therapy has differential effects on poststroke disability and HRQoL up to 1-month after ischemic stroke and TIA. The effect of acute therapy consult is more notable for those with mild deficits, while the effect of acute therapy treatment is more notable for those with moderate to severe deficits. Minimizing time to therapy consults and treatments in the acute hospital period might improve outcomes after ischemic stroke and TIA.
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Isquemia Encefálica/reabilitação , Ataque Isquêmico Transitório/reabilitação , Qualidade de Vida , Reabilitação do Acidente Vascular Cerebral/métodos , Tempo para o Tratamento/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Consumo de Bebidas Alcoólicas/epidemiologia , Isquemia Encefálica/epidemiologia , Fumar Cigarros/epidemiologia , Avaliação da Deficiência , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Razão de Chances , Estudos Prospectivos , Índice de Gravidade de Doença , Fatores SocioeconômicosRESUMO
OBJECTIVE: Assess the association of time to initiation of acute rehabilitation therapy with disability after intracerebral hemorrhage (ICH) and identify predictors of time to initiation of rehabilitation therapy. DESIGN: Retrospective data analysis of prospectively collected data from an ongoing observational cohort study. SETTING: Large comprehensive stroke center in a metropolitan area. PARTICIPANTS: Adults with ICH consecutively admitted (n=203). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Disability was assessed with the modified Rankin Scale (mRS), with poor outcome defined as mRS 4-6 (dependence or worse). Time to initiation of acute rehabilitation therapy was defined as the number of days between hospital admission and the first consult by any rehabilitation therapy specialist (eg, physical therapy, occupational therapy, speech therapy). RESULTS: The median number of days from hospital admission to initiation of acute rehabilitation therapy was 3 (range=2-7). Multivariable logistic regression models indicated that each additional day between admission and initiation of acute rehabilitation therapy was associated with increased odds of poor outcome at 30 days (adjusted odds ratio [OR]=1.151; 95% confidence interval [CI]=1.044-1.268; P=.005) and at 90 days (adjusted OR=1.107; 95% CI=1.003-1.222; P=.044) for patients with ICH. A multivariable linear regression model used to identify the predictors of time to initiation of rehabilitation therapy identified heavy drinking (>5 drinks per day), premorbid mRS<4, presence of pulmonary embolism, and longer length of stay in the intensive care unit as independent predictors of later initiation of acute rehabilitation therapy. CONCLUSIONS: Longer time to initiation of acute rehabilitation therapy after ICH may have persistent effects on poststroke disability. Delays in acute rehabilitation therapy consults should be minimized and may improve outcomes after ICH.
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Hemorragia Cerebral/reabilitação , Avaliação da Deficiência , Tempo para o Tratamento , Consumo de Bebidas Alcoólicas/epidemiologia , Pessoas com Deficiência , Feminino , Humanos , Illinois/epidemiologia , Unidades de Terapia Intensiva , Tempo de Internação/estatística & dados numéricos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Embolia Pulmonar/epidemiologia , Estudos RetrospectivosRESUMO
OBJECTIVES: Neuropathic pain (NP) is a consequence of many chronic conditions. This study aimed to develop an unidimensional NP scale with scores that represent levels of NP and distinguish between individuals with NP and non-NP conditions. METHODS: A candidate item pool of 42 pain quality descriptors was administered to participants with osteoarthritis, rheumatoid arthritis, diabetic neuropathy, and cancer chemotherapy-induced peripheral neuropathy. A subset of pain quality descriptors (items) that best distinguished between participants with and those without NP conditions were identified. Dimensionality of pain descriptors was evaluated in a development sample and cross-validated in a holdout sample. Item responses were calibrated using an item response theory model, and scores were generated on a T-score metric. NP scale scores were evaluated in terms of the reliability, validity, and ability to distinguish between participants with and without conditions typically associated with NP. RESULTS: Of the 42 initial items, 5 were identified for the Patient-Reported Outcome Measurement Information System (PROMIS) Neuropathic Pain Quality Scale. T scores exhibited good discriminatory ability on the basis of receiver-operator characteristic analysis. Score thresholds that optimize sensitivity and specificity were identified. Construct, criterion, and discriminant validity, and reliability of scale scores were supported. CONCLUSIONS: The five-item Patient-Reported Outcome Measurement Information System (PROMIS PQ-Neuro) Neuropathic Pain Quality Scale is a short and practical measure that can be used to identify patients more likely to have NP and to distinguish levels of NP. The data collected will support future research that targets other unidimensional pain quality domains (e.g., nociceptive pain).
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Neuralgia , Medição da Dor/instrumentação , Autorrelato/normas , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Resultado do TratamentoRESUMO
PURPOSE: Measurement invariance is necessary for meaningful group comparisons. The purpose of this study was to test measurement invariance of three patient-reported measures of depressive symptoms between neurologic and community samples. METHODS: The instruments tested included the center for epidemiologic studies depression scale (CESD-20), the patient health questionnaire-9 (PHQ-9), and the patient-reported outcome measurement information system depression short form (PROMIS-D-8). Responses from a community sample were compared to responses from samples with two neurologic conditions: multiple sclerosis and spinal cord injury. Multi-group confirmatory factor analysis was used to evaluate successive levels of measurement invariance: (a) configural invariance, i.e., equivalent item factor structure between groups; (b) metric invariance, i.e., equivalent unstandardized factor loadings between groups; and (c) scalar invariance, i.e., equivalent item intercepts between groups. RESULTS: Results of this study supported metric invariance for the CESD-20, PHQ-9, and PROMIS-D-8 scores between the community sample and the samples with neurologic conditions. The most rigorous form of invariance (i.e., scalar) also holds for the CESD-20 and the PROMIS-D-8. CONCLUSIONS: The current study suggests that depressive symptoms as measured by three different outcome measures have the same meaning across clinical and community samples. Thus, the use of these measures for group comparisons is supported.
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Transtorno Depressivo/diagnóstico , Escalas de Graduação Psiquiátrica/normas , Adulto , Transtorno Depressivo/psicologia , Análise Fatorial , Feminino , Humanos , Sistemas de Informação , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/psicologia , Avaliação de Resultados em Cuidados de Saúde/métodos , Psicometria , Qualidade de Vida , Traumatismos da Medula Espinal/psicologiaRESUMO
PURPOSE: In order to test the difference between group means, the construct measured must have the same meaning for all groups under investigation. This study examined the measurement invariance of responses to the patient-reported outcomes measurement information system (PROMIS) pain behavior (PB) item bank in two samples: the PROMIS calibration sample (Wave 1, N = 426) and a sample recruited from the American Chronic Pain Association (ACPA, N = 750). The ACPA data were collected to increase the number of participants with higher levels of pain. METHODS: Multi-group confirmatory factor analysis (MG-CFA) and two item response theory (IRT)-based differential item functioning (DIF) approaches were employed to evaluate the existence of measurement invariance. RESULTS: MG-CFA results supported metric invariance of the PROMIS-PB, indicating unstandardized factor loadings with equal across samples. DIF analyses revealed that impact of 6 DIF items was negligible. CONCLUSIONS: Based on the results of both MG-CFA and IRT-based DIF approaches, we recommend retaining the original parameter estimates obtained from the combined samples based on the results of MG-CFA.
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Dor Crônica/psicologia , Indicadores Básicos de Saúde , Avaliação de Resultados em Cuidados de Saúde , Psicometria , Autorrelato , Adulto , Dor Crônica/etnologia , Discriminação Psicológica , Análise Fatorial , Feminino , Humanos , Sistemas de Informação , Modelos Logísticos , Masculino , Medição da Dor , Vigilância da População , Psicometria/métodos , Qualidade de Vida , Estados Unidos , Adulto JovemRESUMO
OBJECTIVE: Pain's impact on executive function is understood and specific cognitive abilities may contribute to coping with pain, though past work is confounded by chronic pain populations. This study aims to understand how executive functioning may predict the experience of pain among healthy adults. It was hypothesized that poorer executive functioning would predict more intense pain perception. METHOD: A total of 172 young adults were recruited for participation. Three aspects of executive functioning (i.e., impulsivity, cognitive flexibility, working memory) were assessed before randomizing participants to varying types and levels of stimulated pain. RESULTS: Results supported the hypothesis that poorer performance on tasks of working memory predicts more intense pain perception. CONCLUSIONS: Findings are counter to past work that has found inhibition may be important for coping, and future research is needed to understand the impact of specific cognitive abilities as well as how this may differ for chronic pain.
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Função Executiva , Memória de Curto Prazo , Testes Neuropsicológicos , Percepção da Dor , Humanos , Masculino , Função Executiva/fisiologia , Feminino , Adulto Jovem , Memória de Curto Prazo/fisiologia , Percepção da Dor/fisiologia , Adulto , Adolescente , Comportamento Impulsivo/fisiologia , Medição da DorRESUMO
INTRODUCTION: To help researchers in multiple sclerosis (MS) take advantage of the measurement properties of the PROMIS Pain Interference instrument while maintaining continuity with previous research, we developed and tested a crosswalk table to transform Brief Pain Inventory pain interference scale (BPI-PI) scores to PROMIS-PI short form (PROMIS-PI SF) scores. METHODS: The BPI-PI and the PROMIS-PI SF were administered in two studies that included persons with MS. One sample of 369 participants served as a developmental calibration sample, and a separate sample of 360 served as a validation sample. The crosswalk development included dimensionality assessment, item-level parameter estimation, and assessment of accuracy. BPI-PI and PROMIS-PI T scores were obtained from participants' item responses, and using the crosswalk table, PROMIS-PI T scores were derived from responses to the BPI-PI items. Differences between observed and crosswalked T scores were compared in both samples. RESULTS: For BPI-PI summary scores ranging from 0 to 10, corresponding T scores ranged from 38.6 to 81.2. The mean difference between observed and crosswalked T scores was 0.51 (SD = 3.9) in the calibration sample and -1.47 (SD = 4.2) in the validation sample. Approximately 80 % of crosswalked scores in the calibration sample were within four score points of the observed PROMIS-PI SF scores, and 70 % were within four points in the validation sample. In both samples, the largest differences were at lower levels of the pain interference continuum. CONCLUSIONS: Crosswalked pain interference scores adequately approximated observed PROMIS-PI SF scores in both the calibration and validation samples. MS researchers and clinicians interested in adopting the PROMIS instruments can use this table to transform BPI-PI scores to enable comparisons with other studies and to maintain continuity with previous research.
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Dor Crônica/diagnóstico , Esclerose Múltipla/complicações , Medição da Dor/instrumentação , Dor Crônica/psicologia , Feminino , Humanos , Masculino , Manejo da Dor , Psicometria/estatística & dados numéricos , Qualidade de Vida , Inquéritos e QuestionáriosRESUMO
Background: Similar effect sizes have been reported for the effects of conspiracy, pseudoscientific, and paranormal beliefs on authoritarian attitudes, which points to a conceptual problem at the heart of the conspiracy literature, namely lack of clarity as to what uniquely defines conspiracy beliefs and whether those unique elements contribute distinctly to authoritarian ideologies. To our knowledge, this is the first study to test empirically the predictive power of variance unique to each construct against covariance shared among these constructs when predicting authoritarian and anti-democratic attitudes. Methods: Online survey was administered to 314 participants in 2021 that included a battery of demographic and psychological measures. Hierarchical factor models were used to isolate unique variance from shared covariance among responses to items representing conspiracy, paranormal and pseudoscientific beliefs. Structural equation models were used to test their unique and shared effects on authoritarian and anti-democratic attitudes. Results: We found that our combined measurement model of paranormal thinking, conspiracism, and pseudoscience exhibited exceptional model fit, and that each construct was strongly predictive of both SDO and RWA (r = 0.73-0.86). Once the shared covariance was partitioned into a higher order factor, the residual uniqueness in each first order factors was either negatively related or unrelated to authoritarian and anti-democratic attitudes. Moreover, the higher order factor explained the gross majority of variance in conspiracy (R2 = 0.81) paranormal (R2 = 0.81) and pseudoscientific (R2 = 0.95) beliefs and was a far stronger predictor (ß = 0.85, p < 0.01) of anti-democratic attitudes than political partisanship (ß = 0.17, p < 0.01). Strong partisan identifiers of both parties showed much higher romanticism scores than party moderates. Conclusion and limitations: When predicting authoritarian and anti-democratic attitudes, we found no empirically unique contributions of conspiracy beliefs. Instead, we found that a shared factor, representing a 'romantic' mindset was the main predictor of authoritarian and anti-democratic attitudes. This finding potentially explains failures of interventions in stopping the spread of misinformation and conspiracy theories. Conspiracy theory researchers should refocus on the shared features that conspiracy thinking has with other unwarranted epistemic beliefs to better understand how to halt the spread of misinformation, conspiracy thinking, anti-science attitudes, and even global authoritarianism.
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BACKGROUND: Stroke often leads to chronic motor impairments in the paretic lower limb that can constrain lower extremity movement and negatively impact the ability to navigate stairs or curbs. This cross-sectional study investigated the differences in hip and knee biomechanical strategies during a step-up task between five adults with hemiparetic stroke and five age-matched adults without stroke. METHODS: Participants were instructed to step up onto a 10.2 cm platform, where joint biomechanics were quantified for the hip in the frontal plane and the hip and knee in the sagittal plane. Peak joint kinematics were identified during the leading limb swing phase, and peak joint moments and power were identified during the leading limb pull-up phase of stance. Mixed effects regression models estimated fixed effects of limb (three levels: control dominant, stroke non-paretic, and stroke paretic) on biomechanical outcomes, while a random effect of participant controlled for within-participant correlations. RESULTS: Repeated assessments within participants (approximately 60 trials per lower limb) increased the effective sample size to between 12.0 and 19.6. Altered biomechanical strategies of the paretic lower limb included reduced flexion angles and increased pelvic obliquity angles during swing, decreased power generation in the hip frontal plane during stance, and decreased moment and power generation in the knee sagittal plane during stance. A strategy of substantial interest was the elevated hip sagittal plane moment and power generation in both stroke limbs. CONCLUSIONS: Our findings suggest that chronic motor impairments following stroke can lead to inefficient biomechanical strategies when stepping up.
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Acidente Vascular Cerebral , Adulto , Humanos , Estudos Transversais , Acidente Vascular Cerebral/complicações , Extremidade Inferior , Articulação do Joelho , Tornozelo , Fenômenos Biomecânicos , MarchaRESUMO
BACKGROUND: Achieving mobility with a prosthesis is a common post-amputation rehabilitation goal and primary outcome in prosthetic research studies. Patient-reported outcome measures (PROMs) available to measure prosthetic mobility have practical and psychometric limitations that inhibit their use in clinical care and research. OBJECTIVE: To develop a brief, clinically meaningful, and psychometrically robust PROM to measure prosthetic mobility. DESIGN: A cross-sectional study was conducted to administer previously developed candidate items to a national sample of lower limb prosthesis users. Items were calibrated to an item response theory model and two fixed-length short forms were created. Instruments were assessed for readability, effective range of measurement, agreement with the full item bank, ceiling and floor effects, convergent validity, and known groups validity. SETTING: Participants were recruited using flyers posted in hospitals and prosthetics clinics across the United States, magazine advertisements, notices posted to consumer websites, and direct mailings. PARTICIPANTS: Adult prosthesis users (N = 1091) with unilateral lower limb amputation due to traumatic or dysvascular causes. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Candidate items (N = 105) were administered along with the Patient Reported Outcome Measurement Information System Brief Profile, Prosthesis Evaluation Questionnaire - Mobility Subscale, and Activities-Specific Balance Confidence Scale, and questions created to characterize respondents. RESULTS: A bank of 44 calibrated self-report items, termed the Prosthetic Limb Users Survey of Mobility (PLUS-M), was produced. Clinical and statistical criteria were used to select items for 7- and 12-item short forms. PLUS-M instruments had an 8th grade reading level, measured with precision across a wide range of respondents, exhibited little-to-no ceiling or floor effects, correlated expectedly with scores from existing PROMs, and differentiated between groups of respondents expected to have different levels of mobility. CONCLUSION: The PLUS-M appears to be well suited to measuring prosthetic mobility in people with lower limb amputation. PLUS-M instruments are recommended for use in clinical and research settings.
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Amputados , Membros Artificiais , Adulto , Humanos , Estados Unidos , Extremidade Inferior/cirurgia , Estudos Transversais , Amputação Cirúrgica , Inquéritos e Questionários , Amputados/reabilitaçãoRESUMO
OBJECTIVE: To develop a self-efficacy scale for people living with multiple sclerosis (MS) and spinal cord injury (SCI) that can be used across diagnostic conditions. DESIGN: The scale was developed using modern psychometric methods including item response theory. Items were administered at 3 time-points of a longitudinal survey of individuals with MS and SCI. SETTING: Survey participants with MS were recruited from the National MS Society, and participants with SCI were recruited from the Northwest Regional Spinal Cord Injury Model System and the Shepherd Center at the Virginia Crawford Research Institute in Atlanta, GA. PARTICIPANTS: Adults aged 18 years and older reporting a definitive diagnosis of MS (N=473) or SCI (N=253). INTERVENTIONS: None. MAIN OUTCOME MEASURES: Evaluation of the new self-efficacy measure called the University of Washington Self-Efficacy Scale (UW-SES) included comparisons with the Chronic Disease Self-Efficacy Scale and other patient-reported outcome measures. RESULTS: UW-SES has excellent psychometric properties including well-functioning response categories, no floor effects, and low ceiling effects. A long form (17 items) and a short form (6 items) are available. The correlation between the score on the newly developed scale and the Chronic Disease Self-Efficacy Scale was high (.83), providing support for convergent validity. Higher self-efficacy scores were statistically significantly associated with better mental health, better physical health, less fatigue, less stress, less pain interference, less pain, fewer sleep problems, and lower depressive symptoms. CONCLUSIONS: The UW-SES is a psychometrically sound instrument for measuring self-efficacy, validated in MS and SCI, and can be used across both conditions. Both the long form and the short form are available free of charge.
Assuntos
Avaliação da Deficiência , Esclerose Múltipla/fisiopatologia , Esclerose Múltipla/psicologia , Autoeficácia , Traumatismos da Medula Espinal/fisiopatologia , Traumatismos da Medula Espinal/psicologia , Atividades Cotidianas , Distribuição de Qui-Quadrado , Pessoas com Deficiência , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Psicometria , Qualidade de Vida , Reprodutibilidade dos Testes , Inquéritos e QuestionáriosRESUMO
OBJECTIVES: We sought to develop a mapping function from functional assessment of cancer therapy-melanoma (FACT-M) quality of life scores to the EuroQol-5D (EQ-5D) utility scores. METHODS: FACT-M and EQ-5D scores were collected during a prospective study of melanoma-related quality of life at a tertiary cancer care center in the United States. The study sample was divided into development and validation datasets with equal distributions by cancer stage and treatment status. Censored Least Absolute Deviation (CLAD) and Ordinary Least Squares (OLS) regression analyses were performed using the developmental dataset to derive mapping functions, and model performance was examined through comparisons of residuals and measures of fit in the validation dataset. Exploratory analyses examined the predictive ability of clinical factors and individual subscales. RESULTS: Of 273 patients, 75 were undergoing treatment with 198 in follow-up surveillance. Relatively even distributions were observed by melanoma stage: I/II (n = 102), III (n = 100), and IV (n = 71). OLS regression resulted in a mapping function of EQ-5D = 0.0037*FACT-M+0.2238 with an R(2) 0.499. CLAD regression resulted in a mapping function of EQ-5D = 0.0042*FACT-M+0.1648 with pseudo R(2) 0.328. When applied to the validation dataset, correlations between observed and predicted values resulted in identical coefficients (r = 0.824, P < 0.001). Though the mapping functions were similar, residuals were smaller at the 20th, 40th, and 60th percentiles using the OLS model. The CLAD derived mapping function resulted in smaller residuals only for patients whose EQ-5D = 1. CONCLUSIONS: The OLS mapping function demonstrated better predictive ability and will facilitate the derivation of utilities when direct population preference measures are not available.
Assuntos
Melanoma/terapia , Qualidade de Vida , Inquéritos e Questionários , Adulto , Idoso , Feminino , Humanos , Masculino , Melanoma/psicologia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Estudos Prospectivos , Reprodutibilidade dos Testes , Fatores SocioeconômicosRESUMO
ABSTRACT: This study aims to compare delivery of acute rehabilitation therapy using metrics reflecting distinct aspects of rehabilitation therapy services. Seven general medical-surgical hospitals in Illinois and Indiana prospectively collected rehabilitation therapy data. De-identified data on all patients who received any type of acute rehabilitation therapy (nâ=â35,449) were extracted and reported as aggregate of minutes of therapy services per discipline. Metrics included therapy types, total minutes, and minutes per day (intensity), as charted by therapists. Extended hospital stay was defined as a length of stay (LOS) longer than Medicare's geometric mean LOS. Discharge destination was coded as postacute care or home discharge. Substantial variability was observed in types, number of minutes, and intensity of therapy services by condition and hospital. The odds of an extended hospital stay increased with increased number of minutes, increased number of therapy types, and decreased with increased rehabilitation intensity. This comparative approach to assessing provision of acute therapy services reflect differential effects of service provision on LOS and discharge destination. Investigators, policymakers, and hospital administrators should examine multiple metrics of rehabilitation therapy provision when evaluating the impact of health care processes on patient outcomes.