Detalhe da pesquisa
1.
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.
Arch Toxicol
; 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38755480
2.
Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines.
J Org Chem
; 83(12): 6728-6740, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29812939
3.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat Chem Biol
; 11(3): 189-91, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25622091
4.
Chan-Evans-Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem.
J Org Chem
; 81(9): 3942-50, 2016 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27045570
5.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
J Med Chem
; 67(6): 4541-4559, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38466661
6.
A patent review of MAT2a inhibitors (2018-2021).
Expert Opin Ther Pat
; 32(10): 1043-1053, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36043503
7.
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem
; 65(3): 2262-2287, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34995458
8.
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
J Med Chem
; 64(15): 10711-10741, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34260229
9.
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J Med Chem
; 64(15): 10742-10771, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34232650
10.
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.
J Med Chem
; 64(15): 10806-10833, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34251219
11.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(6): 3249-3281, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33662213
12.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(15): 10772-10805, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255512
13.
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
J Med Chem
; 63(10): 5212-5241, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321240
14.
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family.
ACS Med Chem Lett
; 11(8): 1581-1587, 2020 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832027
15.
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.
J Med Chem
; 63(17): 9093-9126, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32702236
16.
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation.
Science
; 368(6489): 387-394, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32193360
17.
Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.
J Med Chem
; 61(10): 4317-4334, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29656650
18.
Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
J Med Chem
; 58(17): 6803-18, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26287310
19.
Total synthesis of aplyronine C.
Org Lett
; 15(12): 3118-21, 2013 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23730909
20.
Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
J Med Chem
; 56(15): 6156-74, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23829483