Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).

Maor-Nof, Maya; Shipony, Zohar; Lopez-Gonzalez, Rodrigo; Nakayama, Lisa; Zhang, Yong-Jie; Couthouis, Julien; Blum, Jacob A; Castruita, Patricia A; Linares, Gabriel R; Ruan, Kai; Ramaswami, Gokul; Simon, David J; Nof, Aviv; Santana, Manuel; Han, Kyuho; Sinnott-Armstrong, Nasa; Bassik, Michael C; Geschwind, Daniel H; Tessier-Lavigne, Marc; Attardi, Laura D; Lloyd, Thomas E; Ichida, Justin K; Gao, Fen-Biao; Greenleaf, William J; Yokoyama, Jennifer S; Petrucelli, Leonard; Gitler, Aaron D.

Cell ; 184(3): 689-708.e20, 2021 02 04.

Artigo em Inglês | MEDLINE | ID: mdl-33482083

2.

The Mettl3 epitranscriptomic writer amplifies p53 stress responses.

Raj, Nitin; Wang, Mengxiong; Seoane, Jose A; Zhao, Richard L; Kaiser, Alyssa M; Moonie, Nancie A; Demeter, Janos; Boutelle, Anthony M; Kerr, Craig H; Mulligan, Abigail S; Moffatt, Clare; Zeng, Shelya X; Lu, Hua; Barna, Maria; Curtis, Christina; Chang, Howard Y; Jackson, Peter K; Attardi, Laura D.

Mol Cell ; 82(13): 2370-2384.e10, 2022 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-35512709

3.

p53 governs an AT1 differentiation programme in lung cancer suppression.

Kaiser, Alyssa M; Gatto, Alberto; Hanson, Kathryn J; Zhao, Richard L; Raj, Nitin; Ozawa, Michael G; Seoane, José A; Bieging-Rolett, Kathryn T; Wang, Mengxiong; Li, Irene; Trope, Winston L; Liou, Douglas Z; Shrager, Joseph B; Plevritis, Sylvia K; Newman, Aaron M; Van Rechem, Capucine; Attardi, Laura D.

Nature ; 619(7971): 851-859, 2023 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-37468633

4.

Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.

Bieging-Rolett, Kathryn T; Kaiser, Alyssa M; Morgens, David W; Boutelle, Anthony M; Seoane, Jose A; Van Nostrand, Eric L; Zhu, Changyu; Houlihan, Shauna L; Mello, Stephano S; Yee, Brian A; McClendon, Jacob; Pierce, Sarah E; Winters, Ian P; Wang, Mengxiong; Connolly, Andrew J; Lowe, Scott W; Curtis, Christina; Yeo, Gene W; Winslow, Monte M; Bassik, Michael C; Attardi, Laura D.

Mol Cell ; 80(3): 452-469.e9, 2020 11 05.

Artigo em Inglês | MEDLINE | ID: mdl-33157015

5.

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.

Brady, Colleen A; Jiang, Dadi; Mello, Stephano S; Johnson, Thomas M; Jarvis, Lesley A; Kozak, Margaret M; Kenzelmann Broz, Daniela; Basak, Shashwati; Park, Eunice J; McLaughlin, Margaret E; Karnezis, Anthony N; Attardi, Laura D.

Cell ; 145(4): 571-83, 2011 May 13.

Artigo em Inglês | MEDLINE | ID: mdl-21565614

6.

Multifaceted role for p53 in pancreatic cancer suppression.

Mello, Stephano S; Flowers, Brittany M; Mazur, Pawel K; Lee, James J; Müller, Fabian; Denny, Sarah K; Ferreira, Sofia; Hanson, Kathryn; Kim, Seung K; Greenleaf, William J; Wood, Laura D; Attardi, Laura D.

Proc Natl Acad Sci U S A ; 120(10): e2211937120, 2023 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-36848578

7.

A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.

Huarte, Maite; Guttman, Mitchell; Feldser, David; Garber, Manuel; Koziol, Magdalena J; Kenzelmann-Broz, Daniela; Khalil, Ahmad M; Zuk, Or; Amit, Ido; Rabani, Michal; Attardi, Laura D; Regev, Aviv; Lander, Eric S; Jacks, Tyler; Rinn, John L.

Cell ; 142(3): 409-19, 2010 Aug 06.

Artigo em Inglês | MEDLINE | ID: mdl-20673990

8.

Neat1 is a p53-inducible lincRNA essential for transformation suppression.

Mello, Stephano S; Sinow, Carolyn; Raj, Nitin; Mazur, Pawel K; Bieging-Rolett, Kathryn; Broz, Daniela Kenzelmann; Imam, Jamie F Conklin; Vogel, Hannes; Wood, Laura D; Sage, Julien; Hirose, Tetsuro; Nakagawa, Shinichi; Rinn, John; Attardi, Laura D.

Genes Dev ; 31(11): 1095-1108, 2017 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-28698299

9.

Essential role for centromeric factors following p53 loss and oncogenic transformation.

Filipescu, Dan; Naughtin, Monica; Podsypanina, Katrina; Lejour, Vincent; Wilson, Laurence; Gurard-Levin, Zachary A; Orsi, Guillermo A; Simeonova, Iva; Toufektchan, Eleonore; Attardi, Laura D; Toledo, Franck; Almouzni, Geneviève.

Genes Dev ; 31(5): 463-480, 2017 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-28356341

10.

Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.

Calo, Eliezer; Gu, Bo; Bowen, Margot E; Aryan, Fardin; Zalc, Antoine; Liang, Jialiang; Flynn, Ryan A; Swigut, Tomek; Chang, Howard Y; Attardi, Laura D; Wysocka, Joanna.

Nature ; 554(7690): 112-117, 2018 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-29364875

11.

Specifications of the ACMG/AMP variant interpretation guidelines for germline TP53 variants.

Fortuno, Cristina; Lee, Kristy; Olivier, Magali; Pesaran, Tina; Mai, Phuong L; de Andrade, Kelvin C; Attardi, Laura D; Crowley, Stephanie; Evans, D Gareth; Feng, Bing-Jian; Foreman, Ann K M; Frone, Megan N; Huether, Robert; James, Paul A; McGoldrick, Kelly; Mester, Jessica; Seifert, Bryce A; Slavin, Thomas P; Witkowski, Leora; Zhang, Liying; Plon, Sharon E; Spurdle, Amanda B; Savage, Sharon A.

Hum Mutat ; 42(3): 223-236, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33300245

12.

RB goes mitochondrial.

Attardi, Laura D; Sage, Julien.

Genes Dev ; 27(9): 975-9, 2013 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-23651852

13.

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses.

Kenzelmann Broz, Daniela; Spano Mello, Stephano; Bieging, Kathryn T; Jiang, Dadi; Dusek, Rachel L; Brady, Colleen A; Sidow, Arend; Attardi, Laura D.

Genes Dev ; 27(9): 1016-31, 2013 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-23651856

14.

Inappropriate p53 activation during development induces features of CHARGE syndrome.

Van Nostrand, Jeanine L; Brady, Colleen A; Jung, Heiyoun; Fuentes, Daniel R; Kozak, Margaret M; Johnson, Thomas M; Lin, Chieh-Yu; Lin, Chien-Jung; Swiderski, Donald L; Vogel, Hannes; Bernstein, Jonathan A; Attié-Bitach, Tania; Chang, Ching-Pin; Wysocka, Joanna; Martin, Donna M; Attardi, Laura D.

Nature ; 514(7521): 228-32, 2014 Oct 09.

Artigo em Inglês | MEDLINE | ID: mdl-25119037

15.

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage.

Younger, Scott T; Kenzelmann-Broz, Daniela; Jung, Heiyoun; Attardi, Laura D; Rinn, John L.

Nucleic Acids Res ; 43(9): 4447-62, 2015 May 19.

Artigo em Inglês | MEDLINE | ID: mdl-25883152

16.

Illuminating p53 function in cancer with genetically engineered mouse models.

Garcia, Patty B; Attardi, Laura D.

Semin Cell Dev Biol ; 27: 74-85, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24394915

17.

Cancer: A piece of the p53 puzzle.

Bieging, Kathryn T; Attardi, Laura D.

Nature ; 520(7545): 37-8, 2015 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-25799989

18.

The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation.

Basak, Shashwati; Jacobs, Suzanne B R; Krieg, Adam J; Pathak, Navneeta; Zeng, Qi; Kaldis, Philipp; Giaccia, Amato J; Attardi, Laura D.

Mol Cell ; 30(3): 303-14, 2008 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-18471976

19.

The role of apoptosis in cancer development and treatment response.

Brown, J Martin; Attardi, Laura D.

Nat Rev Cancer ; 5(3): 231-7, 2005 03.

Artigo em Inglês | MEDLINE | ID: mdl-15738985

20.

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.

Jiang, Dadi; Brady, Colleen A; Johnson, Thomas M; Lee, Eunice Y; Park, Eunice J; Scott, Matthew P; Attardi, Laura D.

Proc Natl Acad Sci U S A ; 108(41): 17123-8, 2011 Oct 11.

Artigo em Inglês | MEDLINE | ID: mdl-21969549

BVS Doenças Infecciosas e Parasitárias

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: