Detalhe da pesquisa
1.
Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.
Bioorg Med Chem Lett
; 21(24): 7516-21, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22041058
2.
Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.
Bioorg Med Chem Lett
; 19(24): 6882-9, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19896847
3.
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.
Bioorg Med Chem Lett
; 19(15): 4034-41, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19541481
4.
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 17(23): 6476-80, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17937986
5.
Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.
J Med Chem
; 47(5): 1081-4, 2004 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14971888
6.
Design, structure-activity relationships, X-ray crystal structure, and energetic contributions of a critical P1 pharmacophore: 3-chloroindole-7-yl-based factor Xa inhibitors.
J Med Chem
; 51(23): 7541-51, 2008 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18998662
7.
Benzopyran sulfonamides as KV1.5 potassium channel blockers.
Bioorg Med Chem Lett
; 17(12): 3271-5, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17462888
8.
Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.
Bioorg Med Chem Lett
; 17(21): 5952-8, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17855089
9.
Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.
Bioorg Med Chem Lett
; 16(18): 4796-9, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870436
10.
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
Bioorg Med Chem Lett
; 15(5): 1435-40, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15713402
11.
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.
Bioorg Med Chem Lett
; 15(24): 5453-8, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16213711
12.
Pharmacologic profile of the selective mitochondrial-K(ATP) opener BMS-191095 for treatment of acute myocardial ischemia.
Cardiovasc Drug Rev
; 20(2): 121-36, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12177690
13.
Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity.
Am J Physiol Heart Circ Physiol
; 287(4): H1747-55, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15371268
14.
One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.
J Org Chem
; 69(1): 188-91, 2004 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14703396
15.
Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.
Bioorg Med Chem Lett
; 14(1): 177-80, 2004 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-14684323
16.
Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase.
Bioorg Med Chem Lett
; 14(4): 1031-4, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15013017
17.
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.
Bioorg Med Chem Lett
; 14(1): 99-102, 2004 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-14684307
18.
N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase.
Bioorg Med Chem Lett
; 14(4): 1027-30, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15013016