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Neurobiol Aging ; 35(9): 2021-8, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24731519

RESUMO

Converging evidence suggests that psychotic Alzheimer's disease (AD + P) is associated with an acceleration of frontal degeneration, with tau pathology playing a primary role. Previous histopathologic and biomarker studies have specifically implicated tau pathology in this condition. To precisely quantify tau abnormalities in the frontal cortex in AD + P, we used a sensitive biochemical assay of total tau and 4 epitopes of phospho-tau relevant in AD pathology in a postmortem sample of AD + P and AD - P. Samples of superior frontal gyrus from 26 AD subjects without psychosis and 45 AD + P subjects with psychosis were analyzed. Results of enzyme-linked immunosorbent assay demonstrate that AD + P females, but not males, had significantly higher levels of phosphorylated tau in the frontal cortex. In males, but not females, AD + P was associated with the presence of α-synuclein pathology. These results support a gender dissociation of pathology in AD + P. The design of future studies aimed at the elucidation of cognitive and/or functional outcomes; regional brain metabolic deficits; or genetic correlates of AD + P should take gender into consideration.


Assuntos
Doença de Alzheimer/metabolismo , Doença de Alzheimer/patologia , Lobo Frontal/metabolismo , Lobo Frontal/patologia , Transtornos Psicóticos/metabolismo , Transtornos Psicóticos/patologia , Caracteres Sexuais , Proteínas tau/metabolismo , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/complicações , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Emaranhados Neurofibrilares/metabolismo , Emaranhados Neurofibrilares/patologia , Fosforilação , Transtornos Psicóticos/etiologia , alfa-Sinucleína/metabolismo
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