RESUMO
CONTEXT: The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4. DESIGN: Randomized, double-blind, cross-over intervention study. SETTING: NIH clinical center. PATIENTS: Ten thyroidectomized patients. INTERVENTIONS: Study participants were treated with L-T3 or L-T4 with a target TSH >or= 0.5 Assuntos
Terapia de Reposição Hormonal
, Hipotireoidismo/tratamento farmacológico
, Tiroxina/uso terapêutico
, Tri-Iodotironina/uso terapêutico
, Área Sob a Curva
, Estudos Cross-Over
, Método Duplo-Cego
, Feminino
, Humanos
, Hipotireoidismo/sangue
, Hipotireoidismo/cirurgia
, Masculino
, Taxa de Depuração Metabólica
, Pessoa de Meia-Idade
, Equivalência Terapêutica
, Testes de Função Tireóidea
, Tireoidectomia
, Tireotropina/sangue
, Tiroxina/farmacocinética
, Resultado do Tratamento
, Tri-Iodotironina/farmacocinética