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2.
NPJ Microgravity ; 9(1): 25, 2023 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-36977696

RESUMO

The exact pathophysiology of the spaceflight-associated neuro-ocular syndrome (SANS) has so far not been completely elucidated. In this study we assessed the effect of acute head-down tilt position on the mean flow of the intra- and extracranial vessels. Our results suggest a shift from the external to the internal system that might play an important role in the pathomechanism of SANS.

3.
J Am Heart Assoc ; 11(21): e026437, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36300662

RESUMO

Background Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real-time magnetic resonance imaging, beat-to-beat physiological monitoring, and orthostatic stress testing through lower-body negative pressure (LBNP). We conducted a proof-of-concept study in a patient with severe orthostatic hypotension. Methods and Results We included a 46-year-old man with pure autonomic failure. Without and during -30 mmHg LBNP, we obtained 3T real-time magnetic resonance imaging of the cardiac short axis and quantitative flow measurements in the pulmonary trunk and middle cerebral artery. Blood pressure was 118/74 mmHg during supine rest and 58/35 mmHg with LBNP. With LBNP, left ventricular stroke volume decreased by 44.6%, absolute middle cerebral artery flow by 37.6%, and pulmonary trunk flow by 40%. Conclusions Combination of real-time magnetic resonance imaging, LBNP, and continuous blood pressure monitoring provides a promising new approach to study orthostatic intolerance mechanisms in human beings.


Assuntos
Intolerância Ortostática , Masculino , Humanos , Pessoa de Meia-Idade , Pressão Negativa da Região Corporal Inferior , Pressão Sanguínea/fisiologia , Volume Sistólico , Imageamento por Ressonância Magnética
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