Detalhe da pesquisa
1.
Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models.
Malar J
; 22(1): 199, 2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37381013
2.
An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2.
Toxicol Appl Pharmacol
; 443: 116006, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35367236
3.
Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside.
Malar J
; 21(1): 151, 2022 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35570264
4.
Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review.
BMC Infect Dis
; 21(1): 1274, 2021 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34930178
5.
Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale.
J Pharmacokinet Pharmacodyn
; 45(5): 747-762, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30218416
6.
Single-dose pharmacokinetic study comparing the pharmacokinetics of recombinant human chorionic gonadotropin in healthy Japanese and Caucasian women and recombinant human chorionic gonadotropin and urinary human chorionic gonadotropin in healthy Japanese women.
Reprod Med Biol
; 17(1): 52-58, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29371821
7.
Efficacy, safety, and palatability of arpraziquantel (L-praziquantel) orodispersible tablets in children aged 3 months to 6 years infected with Schistosoma in Côte d'Ivoire and Kenya: an open-label, partly randomised, phase 3 trial.
Lancet Infect Dis
; 23(7): 867-876, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893784
8.
Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands.
Lancet Infect Dis
; 23(10): 1164-1174, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37414066
9.
Comparative palatability of orally disintegrating tablets (ODTs) of Praziquantel (L-PZQ and Rac-PZQ) versus current PZQ tablet in African children: A randomized, single-blind, crossover study.
PLoS Negl Trop Dis
; 15(6): e0007370, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34106922
10.
Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.
Lancet Infect Dis
; 21(12): 1713-1724, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34715032
11.
Relative Bioavailability of Orally Dispersible Tablet Formulations of Levo- and Racemic Praziquantel: Two Phase I Studies.
Clin Transl Sci
; 12(1): 66-76, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536632
12.
Open-Label, Randomized, Two-Way, Crossover Study Assessing the Bioequivalence of the Liquid Formulation versus the Freeze-Dried Formulation of Recombinant Human FSH and Recombinant Human LH in a Fixed 2:1 Combination (Pergoveris®) in Pituitary-Suppressed Healthy Women.
Front Endocrinol (Lausanne)
; 8: 371, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29375477