Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Assunto da revista
País de afiliação
Intervalo de ano de publicação
1.
Curr Opin Genet Dev ; 84: 102146, 2024 02.
Artigo em Inglês | MEDLINE | ID: mdl-38171044

RESUMO

Microglia are the major immune cells of the central nervous system (CNS) that perform numerous adaptive functions required for normal CNS development and homeostasis but are also linked to neurodegenerative and behavioral diseases. Microglia development and function are strongly influenced by brain environmental signals that are integrated at the level of transcriptional enhancers to drive specific programs of gene expression. Here, we describe a conceptual framework for how lineage-determining and signal-dependent transcription factors interact to select and regulate the ensembles of enhancers that determine microglia development and function. We then highlight recent findings that advance these concepts and conclude with a consideration of open questions that represent some of the major hurdles to be addressed in the future.


Assuntos
Microglia , Doenças Neurodegenerativas , Humanos , Microglia/fisiologia , Doenças Neurodegenerativas/genética , Sistema Nervoso Central , Encéfalo , Fenótipo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA