Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.

Wellaway, Christopher R; Baldwin, Ian R; Bamborough, Paul; Barker, Daniel; Bartholomew, Michelle A; Chung, Chun-Wa; Dümpelfeld, Birgit; Evans, John P; Fazakerley, Neal J; Homes, Paul; Keeling, Steven P; Lewell, Xiao Q; McNab, Finlay W; Morley, Joanne; Needham, Deborah; Neu, Margarete; van Oosterhout, Antoon J M; Pal, Anshu; Reinhard, Friedrich B M; Rianjongdee, Francesco; Robertson, Craig M; Rowland, Paul; Shah, Rishi R; Sherriff, Emma B; Sloan, Lisa A; Teague, Simon; Thomas, Daniel A; Wellaway, Natalie; Wojno-Picon, Justyna; Woolven, James M; Coe, Diane M.

J Med Chem ; 65(1): 633-664, 2022 01 13.

Artigo em Inglês | MEDLINE | ID: mdl-34928601

2.

3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-ß.

Miller, David D; Bamborough, Paul; Christopher, John A; Baldwin, Ian R; Champigny, Aurelie C; Cutler, Geoffrey J; Kerns, Jeffrey K; Longstaff, Timothy; Mellor, Geoffrey W; Morey, James V; Morse, Mary A; Nie, Hong; Rumsey, William L; Taggart, John J.

Bioorg Med Chem Lett ; 21(8): 2255-8, 2011 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-21429745

3.

Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase Î´.

Spencer, Jonathan A; Baldwin, Ian R; Barton, Nick; Chung, Chun-Wa; Convery, Máire A; Edwards, Christopher D; Jamieson, Craig; Mallett, David N; Rowedder, James E; Rowland, Paul; Thomas, Daniel A; Hardy, Charlotte J.

ACS Med Chem Lett ; 11(7): 1386-1391, 2020 Jul 09.

Artigo em Inglês | MEDLINE | ID: mdl-32676144

4.

From PIM1 to PI3KÎ´ via GSK3ß: Target Hopping through the Kinome.

Henley, Zoë A; Bax, Benjamin D; Inglesby, Laura M; Champigny, Aurélie; Gaines, Simon; Faulder, Paul; Le, Joelle; Thomas, Daniel A; Washio, Yoshiaki; Baldwin, Ian R.

ACS Med Chem Lett ; 8(10): 1093-1098, 2017 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-29057057

5.

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Î´ for the Treatment of Respiratory Disease.

Down, Kenneth; Amour, Augustin; Baldwin, Ian R; Cooper, Anthony W J; Deakin, Angela M; Felton, Leigh M; Guntrip, Stephen B; Hardy, Charlotte; Harrison, Zoë A; Jones, Katherine L; Jones, Paul; Keeling, Suzanne E; Le, Joelle; Livia, Stefano; Lucas, Fiona; Lunniss, Christopher J; Parr, Nigel J; Robinson, Ed; Rowland, Paul; Smith, Sarah; Thomas, Daniel A; Vitulli, Giovanni; Washio, Yoshiaki; Hamblin, J Nicole.

J Med Chem ; 58(18): 7381-99, 2015 Sep 24.

Artigo em Inglês | MEDLINE | ID: mdl-26301626

6.

Total synthesis of (+/-)-acetoxyodontoschismenol using zirconium chemistry.

Baldwin, Ian R; Whitby, Richard J.

Chem Commun (Camb) ; (22): 2786-7, 2003 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-14651104

7.

A practical drug discovery project at the undergraduate level.

Fray, M Jonathan; Macdonald, Simon J F; Baldwin, Ian R; Barton, Nick; Brown, Jack; Campbell, Ian B; Churcher, Ian; Coe, Diane M; Cooper, Anthony W J; Craven, Andrew P; Fisher, Gail; Inglis, Graham G A; Kelly, Henry A; Liddle, John; Maxwell, Aoife C; Patel, Vipulkumar K; Swanson, Stephen; Wellaway, Natalie.

Drug Discov Today ; 18(23-24): 1158-72, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24051399

8.

The synthesis of (-)-isodomoic acid C.

Clayden, Jonathan; Knowles, Faye E; Baldwin, Ian R.

J Am Chem Soc ; 127(8): 2412-3, 2005 Mar 02.

Artigo em Inglês | MEDLINE | ID: mdl-15724994

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