Detalhe da pesquisa
1.
Fragment-based lead discovery of a novel class of small molecule antagonists of neuropeptide B/W receptor subtype 1 (GPR7).
Bioorg Med Chem Lett
; 30(23): 127510, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32898693
2.
Stereoselective addition of 2-phenyloxazol-4-yl trifluoromethanesulfonate to N-sulfinyl imines: application to the synthesis of the HCV protease inhibitor boceprevir.
J Org Chem
; 78(2): 706-10, 2013 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23215022
3.
Synthesis of antifungal glucan synthase inhibitors from enfumafungin.
J Org Chem
; 77(7): 3297-310, 2012 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22423625
4.
The discovery of potent antagonists of NPBWR1 (GPR7).
Bioorg Med Chem Lett
; 22(2): 1014-8, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22197390
5.
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.
Bioorg Med Chem Lett
; 22(9): 3203-7, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22483609
6.
Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human ß3 adrenergic receptor agonists.
Bioorg Med Chem Lett
; 21(6): 1865-70, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353541
7.
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
Bioorg Med Chem Lett
; 20(7): 2311-5, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207138
8.
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Bioorg Med Chem Lett
; 20(16): 4895-900, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20621473
9.
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Bioorg Med Chem Lett
; 20(7): 2106-10, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207541
10.
Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding.
Bioorg Med Chem Lett
; 19(11): 2997-3001, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19406641
11.
Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation.
J Am Chem Soc
; 130(22): 7060-6, 2008 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18461935
12.
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
J Med Chem
; 51(7): 2108-14, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18333607
13.
Diastereoselective Friedel-Crafts alkylation of indoles with chiral alpha-phenyl benzylic cations. Asymmetric synthesis of anti-1,1,2-triarylalkanes.
Org Lett
; 10(14): 3037-40, 2008 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18563906
14.
Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid.
Chem Commun (Camb)
; (4): 419-21, 2007 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17220990
15.
Preparation of 2,5,7-trithiabicyclo[2.2.1]heptane from 1,2-bis-triisopropylsilanylsulfanyl alkenes.
Org Lett
; 8(1): 59-61, 2006 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16381567
16.
3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.
J Med Chem
; 45(9): 1887-900, 2002 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11960500
17.
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
J Med Chem
; 46(12): 2413-26, 2003 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12773045
18.
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
J Med Chem
; 47(21): 5284-97, 2004 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15456273
19.
Dipolar Cycloaddition Route to Diverse Analogues of Cocaine: The 6- and 7-Substituted 3-Phenyltropanes.
J Org Chem
; 62(3): 503-509, 1997 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-11671441
20.
Chemistry and Biology of Cylindrols: Novel Inhibitors of Ras Farnesyl-Protein Transferase from Cylindrocarpon lucidum.
J Org Chem
; 61(22): 7727-7737, 1996 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667727