1.
Bioorg Med Chem Lett
; 16(18): 4922-30, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16824755
RESUMO
The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (Ki = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure.