Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance.

Rubio-Cosials, Anna; Schulz, Eike C; Lambertsen, Lotte; Smyshlyaev, Georgy; Rojas-Cordova, Carlos; Forslund, Kristoffer; Karaca, Ezgi; Bebel, Aleksandra; Bork, Peer; Barabas, Orsolya.

Cell ; 173(1): 208-220.e20, 2018 03 22.

Artigo em Inglês | MEDLINE | ID: mdl-29551265

2.

The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans.

Weng, Chenchun; Kosalka, Joanna; Berkyurek, Ahmet C; Stempor, Przemyslaw; Feng, Xuezhu; Mao, Hui; Zeng, Chenming; Li, Wen-Jun; Yan, Yong-Hong; Dong, Meng-Qiu; Morero, Natalia Rosalía; Zuliani, Cecilia; Barabas, Orsolya; Ahringer, Julie; Guang, Shouhong; Miska, Eric A.

Genes Dev ; 33(1-2): 90-102, 2019 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-30567997

3.

First full views of a CRISPR-guided system for gene insertion.

Barabas, Orsolya; Rice, Phoebe A.

Nature ; 613(7945): 634-635, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36631579

4.

Engineered Sleeping Beauty transposase redirects transposon integration away from genes.

Miskey, Csaba; Kesselring, Lisa; Querques, Irma; Abrusán, György; Barabas, Orsolya; Ivics, Zoltán.

Nucleic Acids Res ; 50(5): 2807-2825, 2022 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-35188569

5.

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.

Khedkar, Supriya; Smyshlyaev, Georgy; Letunic, Ivica; Maistrenko, Oleksandr M; Coelho, Luis Pedro; Orakov, Askarbek; Forslund, Sofia K; Hildebrand, Falk; Luetge, Mechthild; Schmidt, Thomas S B; Barabas, Orsolya; Bork, Peer.

Nucleic Acids Res ; 50(6): 3155-3168, 2022 04 08.

Artigo em Inglês | MEDLINE | ID: mdl-35323968

6.

Mechanism of IS200/IS605 family DNA transposases: activation and transposon-directed target site selection.

Barabas, Orsolya; Ronning, Donald R; Guynet, Catherine; Hickman, Alison Burgess; Ton-Hoang, Bao; Chandler, Michael; Dyda, Fred.

Cell ; 132(2): 208-20, 2008 Jan 25.

Artigo em Inglês | MEDLINE | ID: mdl-18243097

7.

Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes.

Smyshlyaev, Georgy; Bateman, Alex; Barabas, Orsolya.

Mol Syst Biol ; 17(5): e9880, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-34018328

8.

A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming.

Kesselring, Lisa; Miskey, Csaba; Zuliani, Cecilia; Querques, Irma; Kapitonov, Vladimir; Laukó, Andrea; Fehér, Anita; Palazzo, Antonio; Diem, Tanja; Lustig, Janna; Sebe, Attila; Wang, Yongming; Dinnyés, András; Izsvák, Zsuzsanna; Barabas, Orsolya; Ivics, Zoltán.

Nucleic Acids Res ; 48(1): 316-331, 2020 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-31777924

9.

Towards Dissecting the Mechanism of Protein Phosphatase-1 Inhibition by Its C-Terminal Phosphorylation.

Salvi, Francesca; Hoermann, Bernhard; Del Pino García, Javier; Fontanillo, Miriam; Derua, Rita; Beullens, Monique; Bollen, Mathieu; Barabas, Orsolya; Köhn, Maja.

Chembiochem ; 22(5): 834-838, 2021 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-33085143

10.

Snapshots of a genetic cut-and-paste.

Barabas, Orsolya.

Nature ; 575(7783): 447-448, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31745352

11.

Targeting IS608 transposon integration to highly specific sequences by structure-based transposon engineering.

Morero, Natalia Rosalía; Zuliani, Cecilia; Kumar, Banushree; Bebel, Aleksandra; Okamoto, Sachi; Guynet, Catherine; Hickman, Alison Burgess; Chandler, Michael; Dyda, Fred; Barabas, Orsolya.

Nucleic Acids Res ; 46(8): 4152-4163, 2018 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-29635476

12.

Conjugative transposition of the vancomycin resistance carrying Tn1549: enzymatic requirements and target site preferences.

Lambertsen, Lotte; Rubio-Cosials, Anna; Patil, Kiran Raosaheb; Barabas, Orsolya.

Mol Microbiol ; 107(5): 639-658, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29271522

13.

Structural Determinants of Sleeping Beauty Transposase Activity.

Abrusán, György; Yant, Stephen R; Szilágyi, András; Marsh, Joseph A; Mátés, Lajos; Izsvák, Zsuzsanna; Barabás, Orsolya; Ivics, Zoltán.

Mol Ther ; 24(8): 1369-77, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27401040

14.

Resetting the site: redirecting integration of an insertion sequence in a predictable way.

Guynet, Catherine; Achard, Adeline; Hoang, Bao Ton; Barabas, Orsolya; Hickman, Alison Burgess; Dyda, Frederick; Chandler, Michael.

Mol Cell ; 34(5): 612-9, 2009 Jun 12.

Artigo em Inglês | MEDLINE | ID: mdl-19524540

15.

An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum.

Bock, Thomas; Chen, Wei-Hua; Ori, Alessandro; Malik, Nayab; Silva-Martin, Noella; Huerta-Cepas, Jaime; Powell, Sean T; Kastritis, Panagiotis L; Smyshlyaev, Georgy; Vonkova, Ivana; Kirkpatrick, Joanna; Doerks, Tobias; Nesme, Leo; Baßler, Jochen; Kos, Martin; Hurt, Ed; Carlomagno, Teresa; Gavin, Anne-Claude; Barabas, Orsolya; Müller, Christoph W; van Noort, Vera; Beck, Martin; Bork, Peer.

Nucleic Acids Res ; 42(22): 13525-33, 2014 Dec 16.

Artigo em Inglês | MEDLINE | ID: mdl-25398899

16.

Acquisition of an Archaea-like ribonuclease H domain by plant L1 retrotransposons supports modular evolution.

Smyshlyaev, Georgy; Voigt, Franka; Blinov, Alexander; Barabas, Orsolya; Novikova, Olga.

Proc Natl Acad Sci U S A ; 110(50): 20140-5, 2013 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-24277848

17.

Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.

Barabás, Orsolya; Németh, Veronika; Bodor, Andrea; Perczel, András; Rosta, Edina; Kele, Zoltán; Zagyva, Imre; Szabadka, Zoltán; Grolmusz, Vince I; Wilmanns, Matthias; Vértessy, Beáta G.

Nucleic Acids Res ; 41(22): 10542-55, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23982515

18.

DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans.

Hickman, Alison Burgess; James, Jeffrey A; Barabas, Orsolya; Pasternak, Cécile; Ton-Hoang, Bao; Chandler, Michael; Sommer, Suzanne; Dyda, Fred.

EMBO J ; 29(22): 3840-52, 2010 Nov 17.

Artigo em Inglês | MEDLINE | ID: mdl-20890269

19.

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc.

Voigt, Franka; Reuter, Michael; Kasaruho, Anisa; Schulz, Eike C; Pillai, Ramesh S; Barabas, Orsolya.

RNA ; 18(12): 2128-34, 2012 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23086923

20.

Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.

Németh-Pongrácz, Veronika; Barabás, Orsolya; Fuxreiter, Mónika; Simon, István; Pichová, Iva; Rumlová, Michalea; Zábranská, Helena; Svergun, Dmitri; Petoukhov, Maxim; Harmat, Veronika; Klement, Eva; Hunyadi-Gulyás, Eva; Medzihradszky, Katalin F; Kónya, Emese; Vértessy, Beáta G.

Nucleic Acids Res ; 35(2): 495-505, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17169987

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