Detalhe da pesquisa
1.
Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology.
Acta Neuropathol
; 137(5): 825-836, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30805666
2.
Immunological memory to hyperphosphorylated tau in asymptomatic individuals.
Acta Neuropathol
; 133(5): 767-783, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28341999
3.
Targeting microglia for the treatment of Alzheimer's Disease.
Glia
; 64(10): 1710-32, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27100611
4.
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Glia
; 64(10): 1788-94, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27246804
5.
Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition.
Alzheimers Dement
; 12(9): 964-976, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27107518
6.
Anti-Aß antibodies incapable of reducing cerebral Aß oligomers fail to attenuate spatial reference memory deficits in J20 mice.
Neurobiol Dis
; 82: 372-384, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26215784
7.
Neutralization of soluble, synaptotoxic amyloid ß species by antibodies is epitope specific.
J Neurosci
; 32(8): 2696-702, 2012 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357853
8.
Arylsulfonamide pyrimidines as VLA-4 antagonists.
Bioorg Med Chem Lett
; 23(10): 3070-4, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562062
9.
PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration.
Bioorg Med Chem Lett
; 23(14): 4117-9, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23743283
10.
Orally available and efficacious α4ß1/α4ß7 integrin inhibitors.
Bioorg Med Chem Lett
; 23(15): 4370-3, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23777782
11.
Vascular alterations in PDAPP mice after anti-Aß immunotherapy: Implications for amyloid-related imaging abnormalities.
Alzheimers Dement
; 9(5 Suppl): S105-15, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23583235
12.
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.
Bioorg Med Chem Lett
; 21(12): 3726-9, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21570836
13.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg Med Chem Lett
; 21(6): 1838-43, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316234
14.
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg Med Chem Lett
; 21(18): 5521-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813278
15.
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorg Med Chem Lett
; 21(1): 315-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21112785
16.
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Bioorg Med Chem Lett
; 20(24): 7303-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21071223
17.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833041
18.
Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.
J Clin Invest
; 116(11): 3060-9, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17080199
19.
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 19(17): 4920-3, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19660943
20.
Monitoring Blood-Brain Barrier Integrity Following Amyloid-ß Immunotherapy Using Gadolinium-Enhanced MRI in a PDAPP Mouse Model.
J Alzheimers Dis
; 54(2): 723-35, 2016 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27567811