Detalhe da pesquisa
1.
An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii.
J Infect Dis
; 229(2): 558-566, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37889572
2.
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.
Antimicrob Agents Chemother
; 67(4): e0142522, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920244
3.
P-Glycoprotein-Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium.
J Infect Dis
; 220(7): 1188-1198, 2019 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31180118
4.
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
J Infect Dis
; 219(9): 1464-1473, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423128
5.
Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31061151
6.
Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555627
7.
Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection.
J Infect Dis
; 216(1): 55-63, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541457
8.
Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.
J Infect Dis
; 215(8): 1275-1284, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329187
9.
5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533246
10.
Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.
J Antimicrob Chemother
; 72(8): 2334-2341, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28486633
11.
A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.
J Infect Dis
; 214(12): 1850-1855, 2016 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27738055
12.
Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.
J Infect Dis
; 214(12): 1856-1864, 2016 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27923949
13.
The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites.
Parasitology
; 141(11): 1499-1509, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24927073
14.
Clofazimine pharmacokinetics in HIV-infected adults with diarrhea: Implications of diarrheal disease on absorption of orally administered therapeutics.
CPT Pharmacometrics Syst Pharmacol
; 13(3): 410-423, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38164114
15.
A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer.
bioRxiv
; 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37461469
16.
A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer.
Mol Cancer Ther
; 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38507737
17.
Detection of SARS-CoV-2 in Terrestrial Animals in Southern Nigeria: Potential Cases of Reverse Zoonosis.
Viruses
; 15(5)2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243273
18.
Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1.
Acta Crystallogr F Struct Biol Commun
; 79(Pt 10): 257-266, 2023 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37728609
19.
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron.
Viruses
; 15(2)2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36851745
20.
Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases.
ACS Infect Dis
; 9(11): 2190-2201, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37820055