Detalhe da pesquisa
1.
Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice.
Toxicol Appl Pharmacol
; 406: 115216, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32871117
2.
Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 30(1): 126715, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757666
3.
Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation.
J Pharmacol Exp Ther
; 369(2): 223-233, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30804001
4.
A Historical View and Vision into the Future of the Field of Safety Pharmacology.
Handb Exp Pharmacol
; 229: 3-45, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26091634
5.
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Bioorg Med Chem Lett
; 23(3): 791-6, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265904
6.
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
J Med Chem
; 65(8): 6001-6016, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239336
7.
Murderous Racism as Normal Psychosis: The Case of Dylann Roof.
J Am Psychoanal Assoc
; 69(2): 291-313, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-34039067
8.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704436
9.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
10.
Is there a role for the no observed adverse effect level in safety pharmacology?
J Pharmacol Toxicol Methods
; 105: 106917, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866658
11.
Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry.
J Pharmacol Toxicol Methods
; 98: 106593, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158459
12.
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.
J Med Chem
; 62(9): 4370-4382, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30986068
13.
Points to consider emerging from a mini-workshop on cardiac safety: assessing torsades de pointes liability.
J Pharmacol Toxicol Methods
; 56(2): 91-4, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17707127
14.
ILSI-HESI cardiovascular safety subcommittee dataset: an analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc).
J Pharmacol Toxicol Methods
; 56(2): 95-102, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17588780
15.
ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.
J Pharmacol Toxicol Methods
; 54(2): 116-29, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16843688
16.
Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies.
J Pharmacol Toxicol Methods
; 52(1): 6-11, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15975833
17.
Validation of a motor activity system by a robotically controlled vehicle and using standard reference compounds.
J Pharmacol Toxicol Methods
; 52(1): 159-67, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16006152
18.
Drugs effects on ventricular repolarization: a critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices.
J Pharmacol Toxicol Methods
; 52(1): 12-21, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15967683
19.
Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A.
J Pharmacol Toxicol Methods
; 52(1): 22-9, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15961324
20.
Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance.
Br J Pharmacol
; 172(16): 4002-11, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26031452