Detalhe da pesquisa
1.
Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation.
Bioconjug Chem
; 34(9): 1679-1687, 2023 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37657082
2.
Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes.
J Mol Recognit
; 27(3): 160-72, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24446380
3.
Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors.
Anal Biochem
; 460: 39-46, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24882269
4.
Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors.
Beilstein J Org Chem
; 9: 81-8, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23400330
5.
Biophysical Survey of Small-Molecule ß-Catenin Inhibitors: A Cautionary Tale.
J Med Chem
; 65(10): 7246-7261, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35581674
6.
Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C.
ACS Pharmacol Transl Sci
; 5(11): 1169-1180, 2022 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36407959
7.
New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation.
Org Biomol Chem
; 9(3): 659-62, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21113514
8.
Current strategies for the design of PROTAC linkers: a critical review.
Explor Target Antitumor Ther
; 1(5): 273-312, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-36046485
9.
Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy.
Front Oncol
; 10: 1460, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32974171
10.
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem
; 152: 101-114, 2018 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29702446
11.
Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand.
ACS Omega
; 2(8): 4328-4332, 2017 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31457724
12.
Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.
ACS Infect Dis
; 3(2): 152-161, 2017 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27756124
13.
New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.
J Med Chem
; 59(4): 1492-500, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26367539
14.
Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs.
ACS Chem Biol
; 11(8): 2265-74, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27267810
15.
Dual wavelength asymmetric photochemical synthesis with circularly polarized light.
Chem Sci
; 6(7): 3853-3862, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29218156
16.
Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.
Structure
; 23(12): 2246-2255, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26636255
17.
Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?
ACS Med Chem Lett
; 5(1): 23-28, 2014 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24436777
18.
Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.
Science
; 346(6209): 638-641, 2014 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25323695
19.
Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplinâ A.
ChemMedChem
; 8(1): 149-56, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23184734
20.
Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.
J Med Chem
; 55(4): 1731-50, 2012 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22280363