Detalhe da pesquisa
1.
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Bioorg Med Chem
; 26(11): 2996-3005, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779669
2.
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
Nat Commun
; 8: 15159, 2017 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28537265
3.
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
J Med Chem
; 59(11): 5416-31, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27127993
4.
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.
ACS Infect Dis
; 2(12): 945-957, 2016 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27641613
5.
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Sci Transl Med
; 7(296): 296ra111, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26180101