Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Gene silencing dynamics are modulated by transiently active regulatory elements.

Vermunt, Marit W; Luan, Jing; Zhang, Zhe; Thrasher, A Josephine; Huang, Anran; Saari, Megan S; Khandros, Eugene; Beagrie, Robert A; Zhang, Shiping; Vemulamada, Pranay; Brilleman, Matilda; Lee, Kiwon; Yano, Jennifer A; Giardine, Belinda M; Keller, Cheryl A; Hardison, Ross C; Blobel, Gerd A.

Mol Cell ; 83(5): 715-730.e6, 2023 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-36868189

2.

Enhancers predominantly regulate gene expression during differentiation via transcription initiation.

Larke, Martin S C; Schwessinger, Ron; Nojima, Takayuki; Telenius, Jelena; Beagrie, Robert A; Downes, Damien J; Oudelaar, A Marieke; Truch, Julia; Graham, Bryony; Bender, M A; Proudfoot, Nicholas J; Higgs, Douglas R; Hughes, Jim R.

Mol Cell ; 81(5): 983-997.e7, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33539786

3.

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.

Beagrie, Robert A; Thieme, Christoph J; Annunziatella, Carlo; Baugher, Catherine; Zhang, Yingnan; Schueler, Markus; Kukalev, Alexander; Kempfer, Rieke; Chiariello, Andrea M; Bianco, Simona; Li, Yichao; Davis, Trenton; Scialdone, Antonio; Welch, Lonnie R; Nicodemi, Mario; Pombo, Ana.

Nat Methods ; 20(7): 1037-1047, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37336949

4.

Making connections: enhancers in cellular differentiation.

Herrmann, Jennifer C; Beagrie, Robert A; Hughes, Jim R.

Trends Genet ; 38(4): 395-408, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-34753603

5.

Complex multi-enhancer contacts captured by genome architecture mapping.

Beagrie, Robert A; Scialdone, Antonio; Schueler, Markus; Kraemer, Dorothee C A; Chotalia, Mita; Xie, Sheila Q; Barbieri, Mariano; de Santiago, Inês; Lavitas, Liron-Mark; Branco, Miguel R; Fraser, James; Dostie, Josée; Game, Laurence; Dillon, Niall; Edwards, Paul A W; Nicodemi, Mario; Pombo, Ana.

Nature ; 543(7646): 519-524, 2017 03 23.

Artigo em Inglês | MEDLINE | ID: mdl-28273065

6.

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.

Scott, Caroline; Downes, Damien J; Brown, Jill M; Beagrie, Robert; Olijnik, Aude-Anais; Gosden, Matthew; Schwessinger, Ron; Fisher, Christopher A; Rose, Anna; Ferguson, David J P; Johnson, Errin; Hill, Quentin A; Okoli, Steven; Renella, Raffaele; Ryan, Kate; Brand, Marjorie; Hughes, Jim; Roy, Noemi B A; Higgs, Douglas R; Babbs, Christian; Buckle, Veronica J.

Haematologica ; 106(11): 2960-2970, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-33121234

7.

Cell cycle: Continuous chromatin changes.

Beagrie, Robert A; Pombo, Ana.

Nature ; 547(7661): 34-35, 2017 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-28682328

8.

Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription.

Beagrie, Robert A; Pombo, Ana.

Bioessays ; 38(9): 881-93, 2016 09.

Artigo em Inglês | MEDLINE | ID: mdl-27452946

9.

Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks.

Jung, Mabel Minji; Shen, Siqi; Botten, Giovanni A; Olender, Thomas; Katsumura, Koichi R; Johnson, Kirby D; Soukup, Alexandra A; Liu, Peng; Zhang, Qingzhou; Jensvold, Zena D; Lewis, Peter W; Beagrie, Robert A; Low, Jason Kk; Yang, Lihua; Mackay, Joel P; Godley, Lucy A; Brand, Marjorie; Xu, Jian; Keles, Sunduz; Bresnick, Emery H.

J Clin Invest ; 133(7)2023 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-36809258

10.

Scalable in vitro production of defined mouse erythroblasts.

Francis, Helena S; Harold, Caroline L; Beagrie, Robert A; King, Andrew J; Gosden, Matthew E; Blayney, Joseph W; Jeziorska, Danuta M; Babbs, Christian; Higgs, Douglas R; Kassouf, Mira T.

PLoS One ; 17(1): e0261950, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-34995303

11.

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.

Oudelaar, A Marieke; Beagrie, Robert A; Kassouf, Mira T; Higgs, Douglas R.

Curr Opin Genet Dev ; 67: 18-24, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33221670

12.

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.

Downes, Damien J; Beagrie, Robert A; Gosden, Matthew E; Telenius, Jelena; Carpenter, Stephanie J; Nussbaum, Lea; De Ornellas, Sara; Sergeant, Martin; Eijsbouts, Chris Q; Schwessinger, Ron; Kerry, Jon; Roberts, Nigel; Shivalingam, Arun; El-Sagheer, Afaf; Oudelaar, A Marieke; Brown, Tom; Buckle, Veronica J; Davies, James O J; Hughes, Jim R.

Nat Commun ; 12(1): 531, 2021 01 22.

Artigo em Inglês | MEDLINE | ID: mdl-33483495

13.

Reactivation of a developmentally silenced embryonic globin gene.

King, Andrew J; Songdej, Duantida; Downes, Damien J; Beagrie, Robert A; Liu, Siyu; Buckley, Megan; Hua, Peng; Suciu, Maria C; Marieke Oudelaar, A; Hanssen, Lars L P; Jeziorska, Danuta; Roberts, Nigel; Carpenter, Stephanie J; Francis, Helena; Telenius, Jelena; Olijnik, Aude-Anais; Sharpe, Jacqueline A; Sloane-Stanley, Jacqueline; Eglinton, Jennifer; Kassouf, Mira T; Orkin, Stuart H; Pennacchio, Len A; Davies, James O J; Hughes, Jim R; Higgs, Douglas R; Babbs, Christian.

Nat Commun ; 12(1): 4439, 2021 07 21.

Artigo em Inglês | MEDLINE | ID: mdl-34290235

14.

Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types.

Miar, Ana; Arnaiz, Esther; Bridges, Esther; Beedie, Shaunna; Cribbs, Adam P; Downes, Damien J; Beagrie, Robert A; Rehwinkel, Jan; Harris, Adrian L.

Cancer Res ; 80(23): 5245-5256, 2020 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-33115807

15.

Dynamics of the 4D genome during in vivo lineage specification and differentiation.

Oudelaar, A Marieke; Beagrie, Robert A; Gosden, Matthew; de Ornellas, Sara; Georgiades, Emily; Kerry, Jon; Hidalgo, Daniel; Carrelha, Joana; Shivalingam, Arun; El-Sagheer, Afaf H; Telenius, Jelena M; Brown, Tom; Buckle, Veronica J; Socolovsky, Merav; Higgs, Douglas R; Hughes, Jim R.

Nat Commun ; 11(1): 2722, 2020 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-32483172

16.

Examining Topological Domain Influence on Enhancer Function.

Beagrie, Robert A; Pombo, Ana.

Dev Cell ; 39(5): 523-524, 2016 12 05.

Artigo em Inglês | MEDLINE | ID: mdl-27923117

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Gene silencing dynamics are modulated by transiently active regulatory elements.

Enhancers predominantly regulate gene expression during differentiation via transcription initiation.

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.

Making connections: enhancers in cellular differentiation.

Complex multi-enhancer contacts captured by genome architecture mapping.

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.

Cell cycle: Continuous chromatin changes.

Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription.

Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks.

Scalable in vitro production of defined mouse erythroblasts.

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.

Reactivation of a developmentally silenced embryonic globin gene.

Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types.

Dynamics of the 4D genome during in vivo lineage specification and differentiation.

Examining Topological Domain Influence on Enhancer Function.