Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Safety and Pharmacokinetics of LHF-535, a Potential Treatment for Lassa Fever, in Healthy Adults.

Amberg, Sean M; Snyder, Benjamin; Vliet-Gregg, Portia A; Tarcha, Eric J; Posakony, Jeff; Bedard, Kristin M; Heald, Alison E.

Antimicrob Agents Chemother ; 66(11): e0095122, 2022 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-36314868

2.

A potent Lassa virus antiviral targets an arenavirus virulence determinant.

Madu, Ikenna G; Files, Megan; Gharaibeh, Dima N; Moore, Amy L; Jung, Kie-Hoon; Gowen, Brian B; Dai, Dongcheng; Jones, Kevin F; Tyavanagimatt, Shanthakumar R; Burgeson, James R; Korth, Marcus J; Bedard, Kristin M; Iadonato, Shawn P; Amberg, Sean M.

PLoS Pathog ; 14(12): e1007439, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30576397

3.

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway.

Pattabhi, Sowmya; Wilkins, Courtney R; Dong, Ran; Knoll, Megan L; Posakony, Jeffrey; Kaiser, Shari; Mire, Chad E; Wang, Myra L; Ireton, Renee C; Geisbert, Thomas W; Bedard, Kristin M; Iadonato, Shawn P; Loo, Yueh-Ming; Gale, Michael.

J Virol ; 90(5): 2372-87, 2015 Dec 16.

Artigo em Inglês | MEDLINE | ID: mdl-26676770

4.

Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses.

Bedard, Kristin M; Wang, Myra L; Proll, Sean C; Loo, Yueh-Ming; Katze, Michael G; Gale, Michael; Iadonato, Shawn P.

J Virol ; 86(13): 7334-44, 2012 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-22532686

5.

Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers.

Li, Xiaofan; Zhou, Sihong; Abrahams, Cristina L; Krimm, Stellanie; Smith, Jennifer; Bajjuri, Krishna; Stephenson, Heather T; Henningsen, Robert; Hanson, Jeffrey; Heibeck, Tyler H; Calarese, Daniel; Tran, Cuong; Yin, Gang; Stafford, Ryan L; Yam, Alice Y; Kline, Toni; De Almeida, Venita I; Sato, Aaron K; Lupher, Mark; Bedard, Kristin; Hallam, Trevor J.

Mol Cancer Ther ; 22(2): 155-167, 2023 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-36459691

6.

Lassa antiviral LHF-535 protects guinea pigs from lethal challenge.

Cashman, Kathleen A; Wilkinson, Eric R; Posakony, Jeffrey; Madu, Ikenna G; Tarcha, Eric J; Lustig, Kurt H; Korth, Marcus J; Bedard, Kristin M; Amberg, Sean M.

Sci Rep ; 12(1): 19911, 2022 11 19.

Artigo em Inglês | MEDLINE | ID: mdl-36402782

7.

Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19.

Frumkin, Lyn R; Lucas, Michaela; Scribner, Curtis L; Ortega-Heinly, Nastassja; Rogers, Jayden; Yin, Gang; Hallam, Trevor J; Yam, Alice; Bedard, Kristin; Begley, Rebecca; Cohen, Courtney A; Badger, Catherine V; Abbasi, Shawn A; Dye, John M; McMillan, Brian; Wallach, Michael; Bricker, Traci L; Joshi, Astha; Boon, Adrianus C M; Pokhrel, Suman; Kraemer, Benjamin R; Lee, Lucia; Kargotich, Stephen; Agochiya, Mahima; John, Tom St; Mochly-Rosen, Daria.

Front Immunol ; 13: 899617, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35720389

8.

The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes.

Bedard, Kristin M; Underbrink, Michael P; Howie, Heather L; Galloway, Denise A.

J Virol ; 82(8): 3894-902, 2008 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-18256157

9.

E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation.

Underbrink, Michael P; Howie, Heather L; Bedard, Kristin M; Koop, Jennifer I; Galloway, Denise A.

J Virol ; 82(21): 10408-17, 2008 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-18715924

10.

Preclinical studies targeting CD74 with STRO-001 antibody-drug conjugate in acute leukemia.

Le, Quy; Tang, Thao; Leonti, Amanda; Castro, Sommer; McKay, Cyd Nourigat; Perkins, LaKeisha; Pardo, Laura; Kirkey, Danielle; Hylkema, Tiffany; Call, Lindsey; Manselle, Makia; Abrahams, Cristina; Bedard, Kristin; Molina, Arturo; Brodersen, Lisa Eidenshinck; Loken, Michael R; Tarlock, Katherine; Meshinchi, Soheil; Loeb, Keith R.

Blood Adv ; 7(9): 1666-1670, 2023 05 09.

Artigo em Inglês | MEDLINE | ID: mdl-36595452

11.

A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.

Probst, Peter; Grigg, John B; Wang, Myra; Muñoz, Ernesto; Loo, Yueh-Ming; Ireton, Renee C; Gale, Michael; Iadonato, Shawn P; Bedard, Kristin M.

Vaccine ; 35(15): 1964-1971, 2017 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-28279563

12.

Targeting FOLR1 in high-risk CBF2AT3-GLIS2 pediatric AML with STRO-002 FOLR1-antibody-drug conjugate.

Tang, Thao; Le, Quy; Castro, Sommer; Pardo, Laura; McKay, Cyd Nourigat; Perkins, LaKeisha; Smith, Jenny; Kirkey, Danielle; Abrahams, Cristina; Bedard, Kristin; Molina, Arturo; Brodersen, Lisa Eidenshinck; Loken, Michael R; Tarlock, Katherine; Meshinchi, Soheil; Loeb, Keith R.

Blood Adv ; 6(22): 5933-5937, 2022 11 22.

Artigo em Inglês | MEDLINE | ID: mdl-36149945

13.

Regulation of picornavirus gene expression.

Bedard, Kristin M; Semler, Bert L.

Microbes Infect ; 6(7): 702-13, 2004 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-15158778

14.

A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation.

Bedard, Kristin M; Daijogo, Sarah; Semler, Bert L.

EMBO J ; 26(2): 459-67, 2007 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-17183366

15.

Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by a viral IRES.

Bedard, Kristin M; Walter, Brandon L; Semler, Bert L.

RNA ; 10(8): 1266-76, 2004 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-15247434

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