Detalhe da pesquisa
1.
Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.
Proc Natl Acad Sci U S A
; 118(48)2021 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34819376
2.
Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase.
Int J Mol Sci
; 23(19)2022 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36232607
3.
Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.
Genes Immun
; 20(5): 383-393, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31019252
4.
Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.
J Struct Biol
; 208(2): 182-190, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31476368
5.
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
PLoS Pathog
; 13(5): e1006399, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28545104
6.
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents.
J Enzyme Inhib Med Chem
; 34(1): 823-828, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30889995
7.
Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.
J Biol Chem
; 291(43): 22793-22805, 2016 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27590338
8.
Secondary structure reshuffling modulates glycosyltransferase function at the membrane.
Nat Chem Biol
; 11(1): 16-8, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25402770
9.
The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
Proteins
; 83(5): 982-8, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25586004
10.
A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase).
Biochem J
; 457(3): 425-34, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24171907
11.
Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
J Struct Biol
; 188(2): 156-64, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25260828
12.
GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.
Mol Microbiol
; 90(2): 356-66, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23962235
13.
Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery.
Pharmaceuticals (Basel)
; 16(11)2023 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38004425
14.
High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
Nat Commun
; 14(1): 4851, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37563123
15.
3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.
J Biol Chem
; 286(31): 27399-405, 2011 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21632536
16.
Characteristics of the GlnH and GlnX Signal Transduction Proteins Controlling PknG-Mediated Phosphorylation of OdhI and 2-Oxoglutarate Dehydrogenase Activity in Corynebacterium glutamicum.
Microbiol Spectr
; 10(6): e0267722, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36445153
17.
The Antibacterial Type VII Secretion System of Bacillus subtilis: Structure and Interactions of the Pseudokinase YukC/EssB.
mBio
; 13(5): e0013422, 2022 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36154281
18.
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.
Mol Microbiol
; 77(5): 1172-85, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20624223
19.
A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG.
mBio
; 12(5): e0171721, 2021 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34607462
20.
Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response.
J Proteomics
; 244: 104276, 2021 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34044169