Detalhe da pesquisa
1.
Discovery and optimization of covalent Bcl-xL antagonists.
Bioorg Med Chem Lett
; 29(23): 126682, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31606346
2.
Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.
Nat Chem Biol
; 12(11): 931-936, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27595327
3.
Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl-1 Inhibitor AZD5991.
CPT Pharmacometrics Syst Pharmacol
; 9(10): 561-570, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32860732
4.
The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells.
Elife
; 82019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31294695
5.
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Nat Commun
; 9(1): 5341, 2018 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559424
6.
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
ACS Med Chem Lett
; 8(2): 239-244, 2017 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28197319
7.
Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".
ACS Med Chem Lett
; 8(11): 1204, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29152055
8.
Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.
Mol Cancer Ther
; 13(2): 386-98, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24344235