Detalhe da pesquisa
1.
Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4.
Bioorg Med Chem Lett
; 24(9): 2066-72, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726805
2.
Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation.
Sci Rep
; 13(1): 2917, 2023 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36806303
3.
Identification of pyrimidine derivatives as hSMG-1 inhibitors.
Bioorg Med Chem Lett
; 22(21): 6636-41, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23021994
4.
Reduction of therapeutic antibody self-association using yeast-display selections and machine learning.
MAbs
; 14(1): 2146629, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36433737
5.
Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody.
MAbs
; 13(1): 1883239, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33557673
6.
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design.
PLoS One
; 15(5): e0232713, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32379792
7.
PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers.
Mol Cancer Ther
; 19(10): 2068-2078, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32747418
8.
Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.
J Med Chem
; 50(15): 3416-9, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608468
9.
5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.
J Med Chem
; 50(24): 6080-94, 2007 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17967002
10.
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
J Med Chem
; 50(23): 5743-51, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17958343
11.
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates.
AAPS J
; 19(4): 1123-1135, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28439809
12.
Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.
J Med Chem
; 49(1): 31-4, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392788
13.
Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.
J Med Chem
; 49(26): 7623-35, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181146
14.
Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.
Org Lett
; 8(21): 4707-10, 2006 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-17020283
15.
Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Structure
; 10(2): 225-35, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11839308
16.
AB-Bind: Antibody binding mutational database for computational affinity predictions.
Protein Sci
; 25(2): 393-409, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26473627
17.
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem Biol
; 10(12): 1173-81, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14700625
18.
Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors.
J Med Chem
; 52(24): 7942-5, 2009 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19916508
19.
Quantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA.
J Med Chem
; 51(22): 7154-60, 2008 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18959400
20.
Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.
J Med Chem
; 51(17): 5349-70, 2008 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18690677