Detalhe da pesquisa
1.
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Immunity
; 49(1): 42-55.e6, 2018 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30021146
2.
Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc Natl Acad Sci U S A
; 120(18): e2216342120, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098070
3.
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.
Nat Immunol
; 11(10): 920-7, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20818396
4.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25459880
5.
T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer.
J Immunol
; 203(7): 1897-1908, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31484735
6.
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
Nature
; 513(7516): 95-9, 2014 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25186904
7.
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
Proc Natl Acad Sci U S A
; 111(21): 7753-8, 2014 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24821786
8.
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
J Immunol
; 192(12): 5476-80, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24821972
9.
Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages.
J Immunol
; 188(12): 5829-32, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22593622
10.
Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice.
Gastroenterology
; 142(3): 582-591.e8, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22155173
11.
Signaling lymphocyte activation molecule regulates development of colitis in mice.
Gastroenterology
; 143(6): 1544-1554.e7, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22960654
12.
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.
Int Immunol
; 22(4): 259-70, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20139172
13.
The SLAM and SAP gene families control innate and adaptive immune responses.
Adv Immunol
; 97: 177-250, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18501771
14.
Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice.
Nat Metab
; 2(10): 1181, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-33033401
15.
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice.
Nat Metab
; 2(10): 1113-1125, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32989316
16.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551024
17.
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
ACS Med Chem Lett
; 10(6): 857-862, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223438
18.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31265286
19.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
20.
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Science
; 362(6418): 1064-1069, 2018 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30361383