Detalhe da pesquisa
1.
Hybridization into a Bitopic Ligand Increased Muscarinic Receptor Activation for Isopilocarpine but Not for Pilocarpine Derivatives.
J Nat Prod
; 86(4): 869-881, 2023 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37042802
2.
Structural determinants of sphingosine-1-phosphate receptor selectivity.
Arch Pharm (Weinheim)
; 356(12): e2300387, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37806764
3.
Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking.
Molecules
; 26(11)2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34071603
4.
Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT2B Receptors.
Int J Mol Sci
; 21(24)2020 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33419260
5.
Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt1]DALDA, and KGOP01, Binding to the mu Opioid Receptor.
Molecules
; 25(9)2020 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32365707
6.
Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.
J Biol Chem
; 291(31): 16375-89, 2016 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27298318
7.
Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.
Chemistry
; 22(16): 5563-74, 2016 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26918733
8.
Structural determinants of diphenethylamines for interaction with the κ opioid receptor: Synthesis, pharmacology and molecular modeling studies.
Bioorg Med Chem Lett
; 26(19): 4769-4774, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27567368
9.
Structure versus function-The impact of computational methods on the discovery of specific GPCR-ligands.
Bioorg Med Chem
; 23(14): 3907-12, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25828056
10.
Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins.
Nat Commun
; 15(1): 3537, 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670939
11.
Disrupting TSLP-TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases.
EMBO Mol Med
; 2024 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38877290
12.
Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists.
J Pharmacol Exp Ther
; 344(1): 85-95, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23086229
13.
NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors.
J Pharmacol Exp Ther
; 347(1): 69-79, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23887096
14.
In silico virtual screening approaches for anti-viral drug discovery.
Drug Discov Today Technol
; 9(3): e219-25, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-24990575
15.
Community guidelines for GPCR ligand bias: IUPHAR review 32.
Br J Pharmacol
; 179(14): 3651-3674, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35106752
16.
Allosteric coupling and biased agonism in G protein-coupled receptors.
FEBS J
; 288(8): 2513-2528, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33621418
17.
Exploiting Water Dynamics for Pharmacophore Screening.
Methods Mol Biol
; 2266: 227-238, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33759130
18.
Structural insights into understudied human cytochrome P450 enzymes.
Drug Discov Today
; 26(10): 2456-2464, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34161845
19.
Structure-based identification of dual ligands at the A2AR and PDE10A with anti-proliferative effects in lung cancer cell-lines.
J Cheminform
; 13(1): 17, 2021 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33658076
20.
The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling.
Biochem Pharmacol
; 171: 113687, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31678495