Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mapping human hematopoiesis.

Bernt, Kathrin M.

Nat Immunol ; 25(4): 590-591, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38514889

2.

Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells.

Lin, Huijuan; Cheng, Keren; Kubota, Hiroshi; Lan, Yemin; Riedel, Simone S; Kakiuchi, Kazue; Sasaki, Kotaro; Bernt, Kathrin M; Bartolomei, Marisa S; Luo, Mengcheng; Wang, P Jeremy.

Genes Dev ; 36(11-12): 752-763, 2022 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-35738678

3.

Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.

Riedel, Simone S; Lu, Congcong; Xie, Hongbo M; Nestler, Kevin; Vermunt, Marit W; Lenard, Alexandra; Bennett, Laura; Speck, Nancy A; Hanamura, Ichiro; Lessard, Julie A; Blobel, Gerd A; Garcia, Benjamin A; Bernt, Kathrin M.

Mol Cell ; 81(11): 2332-2348.e9, 2021 06 03.

Artigo em Inglês | MEDLINE | ID: mdl-33974912

4.

ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.

Cao, Zhendong; Budinich, Krista A; Huang, Hua; Ren, Diqiu; Lu, Bin; Zhang, Zhen; Chen, Qingzhou; Zhou, Yeqiao; Huang, Yu-Han; Alikarami, Fatemeh; Kingsley, Molly C; Lenard, Alexandra K; Wakabayashi, Aoi; Khandros, Eugene; Bailis, Will; Qi, Jun; Carroll, Martin P; Blobel, Gerd A; Faryabi, Robert B; Bernt, Kathrin M; Berger, Shelley L; Shi, Junwei.

Mol Cell ; 81(17): 3604-3622.e10, 2021 09 02.

Artigo em Inglês | MEDLINE | ID: mdl-34358447

5.

The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.

Lin, Huijuan; Cossu, Isabella G; Leu, N Adrian; Deshpande, Aniruddha J; Bernt, Kathrin M; Luo, Mengcheng; Wang, P Jeremy.

Development ; 150(9)2023 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-37082953

6.

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.

Chen, Changya; Yu, Wenbao; Alikarami, Fatemeh; Qiu, Qi; Chen, Chia-Hui; Flournoy, Jennifer; Gao, Peng; Uzun, Yasin; Fang, Li; Davenport, James W; Hu, Yuxuan; Zhu, Qin; Wang, Kai; Libbrecht, Clara; Felmeister, Alex; Rozich, Isaiah; Ding, Yang-Yang; Hunger, Stephen P; Felix, Carolyn A; Wu, Hao; Brown, Patrick A; Guest, Erin M; Barrett, David M; Bernt, Kathrin M; Tan, Kai.

Blood ; 139(14): 2198-2211, 2022 04 07.

Artigo em Inglês | MEDLINE | ID: mdl-34864916

7.

Rethinking paraneoplastic eosinophilia.

Bernt, Kathrin M.

Haematologica ; 2024 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-38572550

8.

Longitudinal Large-Scale Semiquantitative Proteomic Data Stability Across Multiple Instrument Platforms.

Lu, Congcong; Glisovic-Aplenc, Tina; Bernt, Kathrin M; Nestler, Kevin; Cesare, Joseph; Cao, Lusha; Lee, Hyoungjoo; Fazelinia, Hossein; Chinwalla, Asif; Xu, Yang; Shestova, Olga; Xing, Yi; Gill, Saar; Li, Mingyao; Garcia, Benjamin; Aplenc, Richard.

J Proteome Res ; 20(11): 5203-5211, 2021 11 05.

Artigo em Inglês | MEDLINE | ID: mdl-34669412

9.

Menin dependence: UBTF-ITD AML joins the club.

Bernt, Kathrin M.

Blood ; 143(7): 567-569, 2024 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-38358850

10.

Do you need the immune system to cure ALL?

Bernt, Kathrin M.

Blood ; 140(13): 1457-1458, 2022 09 29.

Artigo em Inglês | MEDLINE | ID: mdl-36173662

11.

Chromatin-modifying enzymes as modulators of reprogramming.

Onder, Tamer T; Kara, Nergis; Cherry, Anne; Sinha, Amit U; Zhu, Nan; Bernt, Kathrin M; Cahan, Patrick; Marcarci, B Ogan; Unternaehrer, Juli; Gupta, Piyush B; Lander, Eric S; Armstrong, Scott A; Daley, George Q.

Nature ; 483(7391): 598-602, 2012 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-22388813

12.

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.

Deshpande, Aniruddha J; Chen, Liying; Fazio, Maurizio; Sinha, Amit U; Bernt, Kathrin M; Banka, Deepti; Dias, Stuart; Chang, Jenny; Olhava, Edward J; Daigle, Scott R; Richon, Victoria M; Pollock, Roy M; Armstrong, Scott A.

Blood ; 121(13): 2533-41, 2013 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-23361907

13.

FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia.

Sung, Pamela J; Selvam, Murugan; Riedel, Simone S; Xie, Hongbo M; Bryant, Katie; Manning, Bryan; Wertheim, Gerald B; Kulej, Katarzyna; Pham, Lucie; Bowman, Robert L; Peresie, Jennifer; Nemeth, Michael J; Levine, Ross L; Garcia, Benjamin A; Meyer, Sara E; Sidoli, Simone; Bernt, Kathrin M; Carroll, Martin.

Leukemia ; 38(2): 291-301, 2024 02.

Artigo em Inglês | MEDLINE | ID: mdl-38182819

14.

HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas.

Xie, Hongbo M; Bernt, Kathrin M.

Biomolecules ; 12(8)2022 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-36009018

15.

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia.

Pingul, Bianca Y; Huang, Hua; Chen, Qingzhou; Alikarami, Fatemeh; Zhang, Zhen; Qi, Jun; Bernt, Kathrin M; Berger, Shelley L; Cao, Zhendong; Shi, Junwei.

iScience ; 25(10): 105139, 2022 Oct 21.

Artigo em Inglês | MEDLINE | ID: mdl-36193052

16.

Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.

Liu, Yiman; Li, Qinglan; Alikarami, Fatemeh; Barrett, Declan R; Mahdavi, Leila; Li, Hangpeng; Tang, Sylvia; Khan, Tanweer A; Michino, Mayako; Hill, Connor; Song, Lele; Yang, Lu; Li, Yuanyuan; Pokharel, Sheela Pangeni; Stamford, Andrew W; Liverton, Nigel; Renzetti, Louis M; Taylor, Simon; Watt, Gillian F; Ladduwahetty, Tammy; Kargman, Stacia; Meinke, Peter T; Foley, Michael A; Shi, Junwei; Li, Haitao; Carroll, Martin; Chen, Chun-Wei; Gardini, Alessandro; Maillard, Ivan; Huggins, David J; Bernt, Kathrin M; Wan, Liling.

Cancer Discov ; 12(11): 2684-2709, 2022 11 02.

Artigo em Inglês | MEDLINE | ID: mdl-36053276

17.

Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice.

Sutter, Pearl A; Karki, Sangita; Crawley, Ilan; Singh, Vijender; Bernt, Kathrin M; Rowe, David W; Crocker, Stephen J; Bayarsaihan, Dashzeveg; Guzzo, Rosa M.

Bone ; 142: 115677, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33022452

18.

Menin is necessary for long term maintenance of meningioma-1 driven leukemia.

Libbrecht, Clara; Xie, Hongbo M; Kingsley, Molly C; Haladyna, Jessica N; Riedel, Simone S; Alikarami, Fatemeh; Lenard, Alexandra; McGeehan, Gerard M; Ernst, Patricia; Bernt, Kathrin M.

Leukemia ; 35(5): 1405-1417, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33542482

19.

Epigenetic regulation of protein translation in KMT2A-rearranged AML.

Lenard, Alexandra; Xie, Hongbo Michael; Pastuer, Taylor; Shank, Tyler; Libbrecht, Clara; Kingsley, Molly; Riedel, Simone S; Yuan, Zuo-Fei; Zhu, Nan; Neff, Tobias; Bernt, Kathrin M.

Exp Hematol ; 85: 57-69, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32437908

20.

Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML.

Kingsley, Molly C; Xie, Hongbo M; Chen, Bo-Rui; Riedel, Simone S; Pastuer, Taylor; Bollig, Madelyn K; Shank, Tyler; Libbrecht, Clara; Stabler, Sally P; Deshpande, Aniruddha J; Intlekofer, Andrew M; Bernt, Kathrin M.

Blood Adv ; 4(13): 3109-3122, 2020 07 14.

Artigo em Inglês | MEDLINE | ID: mdl-32634241

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Mapping human hematopoiesis.

Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells.

Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.

ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.

The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.

Rethinking paraneoplastic eosinophilia.

Longitudinal Large-Scale Semiquantitative Proteomic Data Stability Across Multiple Instrument Platforms.

Menin dependence: UBTF-ITD AML joins the club.

Do you need the immune system to cure ALL?

Chromatin-modifying enzymes as modulators of reprogramming.

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.

FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia.

HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas.

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia.

Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.

Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice.

Menin is necessary for long term maintenance of meningioma-1 driven leukemia.

Epigenetic regulation of protein translation in KMT2A-rearranged AML.

Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML.