Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Translation and Replication Dynamics of Single RNA Viruses.

Boersma, Sanne; Rabouw, Huib H; Bruurs, Lucas J M; Pavlovic, Tonja; van Vliet, Arno L W; Beumer, Joep; Clevers, Hans; van Kuppeveld, Frank J M; Tanenbaum, Marvin E.

Cell ; 183(7): 1930-1945.e23, 2020 12 23.

Artigo em Inglês | MEDLINE | ID: mdl-33188777

2.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Beumer, Joep; Puschhof, Jens; Bauzá-Martinez, Julia; Martínez-Silgado, Adriana; Elmentaite, Rasa; James, Kylie R; Ross, Alexander; Hendriks, Delilah; Artegiani, Benedetta; Busslinger, Georg A; Ponsioen, Bas; Andersson-Rolf, Amanda; Saftien, Aurelia; Boot, Charelle; Kretzschmar, Kai; Geurts, Maarten H; Bar-Ephraim, Yotam E; Pleguezuelos-Manzano, Cayetano; Post, Yorick; Begthel, Harry; van der Linden, Franka; Lopez-Iglesias, Carmen; van de Wetering, Willine J; van der Linden, Reinier; Peters, Peter J; Heck, Albert J R; Goedhart, Joachim; Snippert, Hugo; Zilbauer, Matthias; Teichmann, Sarah A; Wu, Wei; Clevers, Hans.

Cell ; 181(6): 1291-1306.e19, 2020 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-32407674

3.

Snake Venom Gland Organoids.

Post, Yorick; Puschhof, Jens; Beumer, Joep; Kerkkamp, Harald M; de Bakker, Merijn A G; Slagboom, Julien; de Barbanson, Buys; Wevers, Nienke R; Spijkers, Xandor M; Olivier, Thomas; Kazandjian, Taline D; Ainsworth, Stuart; Iglesias, Carmen Lopez; van de Wetering, Willine J; Heinz, Maria C; van Ineveld, Ravian L; van Kleef, Regina G D M; Begthel, Harry; Korving, Jeroen; Bar-Ephraim, Yotam E; Getreuer, Walter; Rios, Anne C; Westerink, Remco H S; Snippert, Hugo J G; van Oudenaarden, Alexander; Peters, Peter J; Vonk, Freek J; Kool, Jeroen; Richardson, Michael K; Casewell, Nicholas R; Clevers, Hans.

Cell ; 180(2): 233-247.e21, 2020 01 23.

Artigo em Inglês | MEDLINE | ID: mdl-31978343

4.

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.

Gehart, Helmuth; van Es, Johan H; Hamer, Karien; Beumer, Joep; Kretzschmar, Kai; Dekkers, Johanna F; Rios, Anne; Clevers, Hans.

Cell ; 176(5): 1158-1173.e16, 2019 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-30712869

5.

Cell fate specification and differentiation in the adult mammalian intestine.

Beumer, Joep; Clevers, Hans.

Nat Rev Mol Cell Biol ; 22(1): 39-53, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-32958874

6.

How the Gut Feels, Smells, and Talks.

Beumer, Joep; Clevers, Hans.

Cell ; 170(1): 10-11, 2017 06 29.

Artigo em Inglês | MEDLINE | ID: mdl-28666112

7.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Beumer, Joep; Puschhof, Jens; Bauzá-Martinez, Julia; Martínez-Silgado, Adriana; Elmentaite, Rasa; James, Kylie R; Ross, Alexander; Hendriks, Delilah; Artegiani, Benedetta; Busslinger, Georg A; Ponsioen, Bas; Andersson-Rolf, Amanda; Saftien, Aurelia; Boot, Charelle; Kretzschmar, Kai; Geurts, Maarten H; Bar-Ephraim, Yotam E; Pleguezuelos-Manzano, Cayetano; Post, Yorick; Begthel, Harry; van der Linden, Franka; Lopez-Iglesias, Carmen; van de Wetering, Willine J; van der Linden, Reinier; Peters, Peter J; Heck, Albert J R; Goedhart, Joachim; Snippert, Hugo; Zilbauer, Matthias; Teichmann, Sarah A; Wu, Wei; Clevers, Hans.

Cell ; 182(4): 1062-1064, 2020 Aug 20.

Artigo em Inglês | MEDLINE | ID: mdl-32822568

8.

Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli.

Pleguezuelos-Manzano, Cayetano; Puschhof, Jens; Rosendahl Huber, Axel; van Hoeck, Arne; Wood, Henry M; Nomburg, Jason; Gurjao, Carino; Manders, Freek; Dalmasso, Guillaume; Stege, Paul B; Paganelli, Fernanda L; Geurts, Maarten H; Beumer, Joep; Mizutani, Tomohiro; Miao, Yi; van der Linden, Reinier; van der Elst, Stefan; Garcia, K Christopher; Top, Janetta; Willems, Rob J L; Giannakis, Marios; Bonnet, Richard; Quirke, Phil; Meyerson, Matthew; Cuppen, Edwin; van Boxtel, Ruben; Clevers, Hans.

Nature ; 580(7802): 269-273, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32106218

9.

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.

Lamers, Mart M; van der Vaart, Jelte; Knoops, Kèvin; Riesebosch, Samra; Breugem, Tim I; Mykytyn, Anna Z; Beumer, Joep; Schipper, Debby; Bezstarosti, Karel; Koopman, Charlotte D; Groen, Nathalie; Ravelli, Raimond B G; Duimel, Hans Q; Demmers, Jeroen A A; Verjans, Georges M G M; Koopmans, Marion P G; Muraro, Mauro J; Peters, Peter J; Clevers, Hans; Haagmans, Bart L.

EMBO J ; 40(5): e105912, 2021 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-33283287

10.

Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models.

Beumer, Joep; Bauzá-Martinez, Julia; Veth, Tim S; Geurts, Veerle; Boot, Charelle; Gilliam-Vigh, Hannah; Poulsen, Steen S; Knop, Filip K; Wu, Wei; Clevers, Hans.

Proc Natl Acad Sci U S A ; 119(46): e2212057119, 2022 11 16.

Artigo em Inglês | MEDLINE | ID: mdl-36343264

11.

SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models.

Mykytyn, Anna Z; Breugem, Tim I; Geurts, Maarten H; Beumer, Joep; Schipper, Debby; van Acker, Romy; van den Doel, Petra B; van Royen, Martin E; Zhang, Jingshu; Clevers, Hans; Haagmans, Bart L; Lamers, Mart M.

J Virol ; 97(8): e0085123, 2023 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-37555660

12.

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration.

Beumer, Joep; Clevers, Hans.

Development ; 143(20): 3639-3649, 2016 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-27802133

13.

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele.

Basak, Onur; van de Born, Maaike; Korving, Jeroen; Beumer, Joep; van der Elst, Stefan; van Es, Johan H; Clevers, Hans.

EMBO J ; 33(18): 2057-68, 2014 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-25092767

14.

Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma.

Yeddula, Narayana; Xia, Yifeng; Ke, Eugene; Beumer, Joep; Verma, Inder M.

Proc Natl Acad Sci U S A ; 112(47): E6476-85, 2015 Nov 24.

Artigo em Inglês | MEDLINE | ID: mdl-26542681

15.

ROCKin' Intestinal Cell Fate: A Potential Avenue to Improve Glucose Sensitivity.

Beumer, Joep; Clevers, Hans.

Gastroenterology ; 155(4): 974-976, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30201364

16.

Hallmarks of stemness in mammalian tissues.

Beumer, Joep; Clevers, Hans.

Cell Stem Cell ; 31(1): 7-24, 2024 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-38181752

17.

Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids.

Harter, Marius F; Recaldin, Timothy; Gerard, Regine; Avignon, Blandine; Bollen, Yannik; Esposito, Cinzia; Guja-Jarosz, Karolina; Kromer, Kristina; Filip, Adrian; Aubert, Julien; Schneider, Anneliese; Bacac, Marina; Bscheider, Michael; Stokar-Regenscheit, Nadine; Piscuoglio, Salvatore; Beumer, Joep; Gjorevski, Nikolche.

Nat Biomed Eng ; 8(4): 345-360, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38114742

18.

Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease.

Yousef Yengej, Fjodor A; Pou Casellas, Carla; Ammerlaan, Carola M E; Olde Hanhof, Charlotte J A; Dilmen, Emre; Beumer, Joep; Begthel, Harry; Meeder, Elise M G; Hoenderop, Joost G; Rookmaaker, Maarten B; Verhaar, Marianne C; Clevers, Hans.

Cell Rep ; 43(1): 113614, 2024 01 23.

Artigo em Inglês | MEDLINE | ID: mdl-38159278

19.

Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites.

Dayton, Talya L; Alcala, Nicolas; Moonen, Laura; den Hartigh, Lisanne; Geurts, Veerle; Mangiante, Lise; Lap, Lisa; Dost, Antonella F M; Beumer, Joep; Levy, Sonja; van Leeuwaarde, Rachel S; Hackeng, Wenzel M; Samsom, Kris; Voegele, Catherine; Sexton-Oates, Alexandra; Begthel, Harry; Korving, Jeroen; Hillen, Lisa; Brosens, Lodewijk A A; Lantuejoul, Sylvie; Jaksani, Sridevi; Kok, Niels F M; Hartemink, Koen J; Klomp, Houke M; Borel Rinkes, Inne H M; Dingemans, Anne-Marie; Valk, Gerlof D; Vriens, Menno R; Buikhuisen, Wieneke; van den Berg, José; Tesselaar, Margot; Derks, Jules; Speel, Ernst Jan; Foll, Matthieu; Fernández-Cuesta, Lynnette; Clevers, Hans.

Cancer Cell ; 41(12): 2083-2099.e9, 2023 12 11.

Artigo em Inglês | MEDLINE | ID: mdl-38086335

20.

Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.

Martinez-Silgado, Adriana; Yousef Yengej, Fjodor A; Puschhof, Jens; Geurts, Veerle; Boot, Charelle; Geurts, Maarten H; Rookmaaker, Maarten B; Verhaar, Marianne C; Beumer, Joep; Clevers, Hans.

STAR Protoc ; 3(3): 101639, 2022 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-36042877

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Translation and Replication Dynamics of Single RNA Viruses.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Snake Venom Gland Organoids.

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.

Cell fate specification and differentiation in the adult mammalian intestine.

How the Gut Feels, Smells, and Talks.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli.

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.

Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models.

SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models.

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration.

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele.

Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma.

ROCKin' Intestinal Cell Fate: A Potential Avenue to Improve Glucose Sensitivity.

Hallmarks of stemness in mammalian tissues.

Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids.

Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease.

Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites.

Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.