Detalhe da pesquisa
1.
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Nature
; 574(7776): 63-68, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31554967
2.
Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic ß-cell autophagy.
J Biol Chem
; 294(4): 1218-1229, 2019 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30518550
3.
Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84.
FASEB J
; 33(11): 12264-12276, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31415180
4.
Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass.
Diabetologia
; 62(1): 99-111, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30334081
5.
High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.
J Biol Chem
; 293(15): 5731-5745, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29440390
6.
High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice.
Diabetologia
; 58(9): 2074-8, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26071760
7.
Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.
Diabetologia
; 57(1): 129-39, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24149836
8.
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic ß-cells.
J Biol Chem
; 288(37): 26569-82, 2013 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23897822
9.
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse ß-cells by co-ordinating insulin biosynthesis with secretory granule formation.
Mol Metab
; 79: 101845, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38013154
10.
ß-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFß receptor signaling.
iScience
; 26(4): 106477, 2023 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37091234
11.
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.
Cell Metab
; 6(4): 320-8, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17908560
12.
A lipidomic screen of palmitate-treated MIN6 ß-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.
Biochem J
; 435(1): 267-76, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21265737
13.
A Selective Look at Autophagy in Pancreatic ß-Cells.
Diabetes
; 70(6): 1229-1241, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34016598
14.
Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes.
PLoS One
; 16(6): e0252607, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34086738
15.
Short-term inhibition of autophagy benefits pancreatic ß-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding.
Mol Metab
; 40: 101023, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32504884
16.
SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control.
Sci Transl Med
; 12(559)2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32878981
17.
Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.
Cell Metab
; 29(1): 183-191.e7, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30318338
18.
Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism.
Mol Cancer Ther
; 6(10): 2777-85, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17913853
19.
Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.
ChemMedChem
; 12(17): 1449-1457, 2017 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28703484
20.
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.
Diabetes
; 54(9): 2755-63, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16123366