Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion.

van Dijk, David; Sharma, Roshan; Nainys, Juozas; Yim, Kristina; Kathail, Pooja; Carr, Ambrose J; Burdziak, Cassandra; Moon, Kevin R; Chaffer, Christine L; Pattabiraman, Diwakar; Bierie, Brian; Mazutis, Linas; Wolf, Guy; Krishnaswamy, Smita; Pe'er, Dana.

Cell ; 174(3): 716-729.e27, 2018 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-29961576

2.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul, Yoav D; Freinkman, Elizaveta; Comb, William C; Cantor, Jason R; Tam, Wai Leong; Thiru, Prathapan; Kim, Dohoon; Kanarek, Naama; Pacold, Michael E; Chen, Walter W; Bierie, Brian; Possemato, Richard; Reinhardt, Ferenc; Weinberg, Robert A; Yaffe, Michael B; Sabatini, David M.

Cell ; 158(5): 1094-1109, 2014 Aug 28.

Artigo em Inglês | MEDLINE | ID: mdl-25171410

3.

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

Wang, Hua; Bierie, Brian; Li, Andrew G; Pathania, Shailja; Toomire, Kimberly; Dimitrov, Stoil D; Liu, Ben; Gelman, Rebecca; Giobbie-Hurder, Anita; Feunteun, Jean; Polyak, Kornelia; Livingston, David M.

Mol Cell ; 63(2): 277-292, 2016 07 21.

Artigo em Inglês | MEDLINE | ID: mdl-27373334

4.

A requirement for p120-catenin in the metastasis of invasive ductal breast cancer.

Kurley, Sarah J; Tischler, Verena; Bierie, Brian; Novitskiy, Sergey V; Noske, Aurelia; Varga, Zsuzsanna; Zürrer-Härdi, Ursina; Brandt, Simone; Carnahan, Robert H; Cook, Rebecca S; Muller, William J; Richmond, Ann; Reynolds, Albert B.

J Cell Sci ; 134(6)2021 03 17.

Artigo em Inglês | MEDLINE | ID: mdl-33097605

5.

LACTB is a tumour suppressor that modulates lipid metabolism and cell state.

Keckesova, Zuzana; Donaher, Joana Liu; De Cock, Jasmine; Freinkman, Elizaveta; Lingrell, Susanne; Bachovchin, Daniel A; Bierie, Brian; Tischler, Verena; Noske, Aurelia; Okondo, Marian C; Reinhardt, Ferenc; Thiru, Prathapan; Golub, Todd R; Vance, Jean E; Weinberg, Robert A.

Nature ; 543(7647): 681-686, 2017 03 30.

Artigo em Inglês | MEDLINE | ID: mdl-28329758

6.

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells.

Kröger, Cornelia; Afeyan, Alexander; Mraz, Jasmin; Eaton, Elinor Ng; Reinhardt, Ferenc; Khodor, Yevgenia L; Thiru, Prathapan; Bierie, Brian; Ye, Xin; Burge, Christopher B; Weinberg, Robert A.

Proc Natl Acad Sci U S A ; 116(15): 7353-7362, 2019 04 09.

Artigo em Inglês | MEDLINE | ID: mdl-30910979

7.

Integrin-ß4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Bierie, Brian; Pierce, Sarah E; Kroeger, Cornelia; Stover, Daniel G; Pattabiraman, Diwakar R; Thiru, Prathapan; Liu Donaher, Joana; Reinhardt, Ferenc; Chaffer, Christine L; Keckesova, Zuzana; Weinberg, Robert A.

Proc Natl Acad Sci U S A ; 114(12): E2337-E2346, 2017 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-28270621

8.

p120-catenin is essential for terminal end bud function and mammary morphogenesis.

Kurley, Sarah J; Bierie, Brian; Carnahan, Robert H; Lobdell, Nichole A; Davis, Michael A; Hofmann, Ilse; Moses, Harold L; Muller, William J; Reynolds, Albert B.

Development ; 139(10): 1754-64, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22461563

9.

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer.

Bierie, Brian; Moses, Harold L.

Nat Rev Cancer ; 6(7): 506-20, 2006 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-16794634

10.

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state.

Chaffer, Christine L; Brueckmann, Ines; Scheel, Christina; Kaestli, Alicia J; Wiggins, Paul A; Rodrigues, Leonardo O; Brooks, Mary; Reinhardt, Ferenc; Su, Ying; Polyak, Kornelia; Arendt, Lisa M; Kuperwasser, Charlotte; Bierie, Brian; Weinberg, Robert A.

Proc Natl Acad Sci U S A ; 108(19): 7950-5, 2011 May 10.

Artigo em Inglês | MEDLINE | ID: mdl-21498687

11.

ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells.

Lambert, Arthur W; Fiore, Christopher; Chutake, Yogesh; Verhaar, Elisha R; Strasser, Patrick C; Chen, Mei Wei; Farouq, Daneyal; Das, Sunny; Li, Xin; Eaton, Elinor Ng; Zhang, Yun; Liu Donaher, Joana; Engstrom, Ian; Reinhardt, Ferenc; Yuan, Bingbing; Gupta, Sumeet; Wollison, Bruce; Eaton, Matthew; Bierie, Brian; Carulli, John; Olson, Eric R; Guenther, Matthew G; Weinberg, Robert A.

Dev Cell ; 57(24): 2714-2730.e8, 2022 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-36538894

12.

GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma.

Abel, Ty W; Clark, Cara; Bierie, Brian; Chytil, Anna; Aakre, Mary; Gorska, Agnieszka; Moses, Harold L.

Mol Cancer Res ; 7(5): 645-53, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19435821

13.

TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution.

Bierie, Brian; Gorska, Agnieszka E; Stover, Daniel G; Moses, Harold L.

J Cell Physiol ; 219(1): 57-68, 2009 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-19086032

14.

Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.

Yu, Xiuping; Wang, Yongqing; Jiang, Ming; Bierie, Brian; Roy-Burman, Pradip; Shen, Michael M; Taketo, Makoto Mark; Wills, Marcia; Matusik, Robert J.

Prostate ; 69(3): 249-62, 2009 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-18991257

15.

TGF-beta and cancer.

Bierie, Brian; Moses, Harold L.

Cytokine Growth Factor Rev ; 17(1-2): 29-40, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-16289860

16.

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall, Jordan A; Reinhardt, Ferenc; Mercury, Oblaise A; Pattabiraman, Diwakar R; Brooks, Mary W; Dougan, Michael; Lambert, Arthur W; Bierie, Brian; Ploegh, Hidde L; Dougan, Stephanie K; Weinberg, Robert A.

Sci Transl Med ; 10(436)2018 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-29643230

17.

Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis.

Forrester, Elizabeth; Chytil, Anna; Bierie, Brian; Aakre, Mary; Gorska, Agnieszka E; Sharif-Afshar, Ali-Reza; Muller, William J; Moses, Harold L.

Cancer Res ; 65(6): 2296-302, 2005 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-15781643

18.

Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian, Mohammad; Ingram, Jessica R; Dougan, Michael; Dongre, Anushka; Whang, Katherine A; LeGall, Camille; Cragnolini, Juan J; Bierie, Brian; Gostissa, Monica; Gorman, James; Grotenbreg, Gijsbert M; Bhan, Atul; Weinberg, Robert A; Ploegh, Hidde L.

J Exp Med ; 214(8): 2243-2255, 2017 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-28666979

19.

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.

Pattabiraman, Diwakar R; Bierie, Brian; Kober, Katharina Isabelle; Thiru, Prathapan; Krall, Jordan A; Zill, Christina; Reinhardt, Ferenc; Tam, Wai Leong; Weinberg, Robert A.

Science ; 351(6277): aad3680, 2016 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-26941323

20.

Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.

Gallego, Marta I; Bierie, Brian; Hennighausen, Lothar.

Oncogene ; 22(52): 8498-508, 2003 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-14627990

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