Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Non-histone protein methylation as a regulator of cellular signalling and function.

Biggar, Kyle K; Li, Shawn S-C.

Nat Rev Mol Cell Biol ; 16(1): 5-17, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25491103

2.

SnapShot: Lysine Methylation beyond Histones.

Biggar, Kyle K; Wang, Zhentian; Li, Shawn S-C.

Mol Cell ; 68(5): 1016-1016.e1, 2017 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-29220647

3.

A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation.

Lee, Kwan Yin; Chopra, Anand; Burke, Giovanni L; Chen, Ziyan; Greenblatt, Jack F; Biggar, Kyle K; Meneghini, Marc D.

Nucleic Acids Res ; 48(6): 2897-2911, 2020 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-31960028

4.

Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1).

Balasuriya, Nileeka; Davey, Norman E; Johnson, Jared L; Liu, Huadong; Biggar, Kyle K; Cantley, Lewis C; Li, Shawn Shun-Cheng; O'Donoghue, Patrick.

J Biol Chem ; 295(24): 8120-8134, 2020 06 12.

Artigo em Inglês | MEDLINE | ID: mdl-32350110

5.

Identification of in vitro JMJD lysine demethylase candidate substrates via systematic determination of substrate preference.

Hoekstra, Matthew; Biggar, Kyle K.

Anal Biochem ; 633: 114429, 2021 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-34678252

6.

Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity.

Balasuriya, Nileeka; Kunkel, Maya T; Liu, Xuguang; Biggar, Kyle K; Li, Shawn S-C; Newton, Alexandra C; O'Donoghue, Patrick.

J Biol Chem ; 293(27): 10744-10756, 2018 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-29773654

7.

Characterization of ice recrystallization inhibition activity in the novel freeze-responsive protein Fr10 from freeze-tolerant wood frogs, Rana sylvatica.

Le Tri, Dung; Childers, Christine L; Adam, Madeleine K; Ben, Robert N; Storey, Kenneth B; Biggar, Kyle K.

J Therm Biol ; 84: 426-430, 2019 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-31466782

8.

A framework for improving microRNA prediction in non-human genomes.

Peace, Robert J; Biggar, Kyle K; Storey, Kenneth B; Green, James R.

Nucleic Acids Res ; 43(20): e138, 2015 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-26163062

9.

Exploration of low temperature microRNA function in an anoxia tolerant vertebrate ectotherm, the red eared slider turtle (Trachemys scripta elegans).

Biggar, Kyle K; Storey, Kenneth B.

J Therm Biol ; 68(Pt A): 139-146, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28689715

10.

Analysis of microRNA expression during the torpor-arousal cycle of a mammalian hibernator, the 13-lined ground squirrel.

Wu, Cheng-Wei; Biggar, Kyle K; Luu, Bryan E; Szereszewski, Kama E; Storey, Kenneth B.

Physiol Genomics ; 48(6): 388-96, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-27084747

11.

Insight into post-transcriptional gene regulation: stress-responsive microRNAs and their role in the environmental stress survival of tolerant animals.

Biggar, Kyle K; Storey, Kenneth B.

J Exp Biol ; 218(Pt 9): 1281-9, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25954040

12.

A high-throughput protocol for message RNA quantification using RNA dot-blots.

Rouble, Andrew N; Biggar, Kyle K; Storey, Kenneth B.

Anal Biochem ; 452: 31-3, 2014 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-24560727

13.

High-throughput amplification of mature microRNAs in uncharacterized animal models using polyadenylated RNA and stem-loop reverse transcription polymerase chain reaction.

Biggar, Kyle K; Wu, Cheng-Wei; Storey, Kenneth B.

Anal Biochem ; 462: 32-4, 2014 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-24929089

14.

Expression of freeze-responsive proteins, Fr10 and Li16, from freeze-tolerant frogs enhances freezing survival of BmN insect cells.

Biggar, Kyle K; Kotani, Eiji; Furusawa, Toshiharu; Storey, Kenneth B.

FASEB J ; 27(8): 3376-83, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23657819

15.

Unraveling the battle for lysine: A review of the competition among post-translational modifications.

Shukri, Ali H; Lukinovic, Valentina; Charih, François; Biggar, Kyle K.

Biochim Biophys Acta Gene Regul Mech ; 1866(4): 194990, 2023 12.

Artigo em Inglês | MEDLINE | ID: mdl-37748678

16.

Characterization of KDM5 lysine demethylase family substrate preference and identification of novel substrates.

Hoekstra, Matthew; Ridgeway, Nashira H; Biggar, Kyle K.

J Biochem ; 173(1): 31-42, 2022 Dec 27.

Artigo em Inglês | MEDLINE | ID: mdl-36205465

17.

PeSA 2.0: A software tool for peptide specificity analysis implementing positive and negative motifs and motif-based peptide scoring.

Topcu, Emine; Ridgeway, Nashira H; Biggar, Kyle K.

Comput Biol Chem ; 101: 107753, 2022 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-35998543

18.

Assessing the in vitro Binding Affinity of Protein-RNA Interactions Using an RNA Pull-down Technique.

Chopra, Anand; Balbous, Feras; Biggar, Kyle K.

Bio Protoc ; 12(23)2022 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-36561120

19.

Insights into a Cancer-Target Demethylase: Substrate Prediction through Systematic Specificity Analysis for KDM3A.

Chopra, Anand; Willmore, William G; Biggar, Kyle K.

Biomolecules ; 12(5)2022 04 27.

Artigo em Inglês | MEDLINE | ID: mdl-35625569

20.

Assessing sequence-based protein-protein interaction predictors for use in therapeutic peptide engineering.

Charih, François; Biggar, Kyle K; Green, James R.

Sci Rep ; 12(1): 9610, 2022 06 10.

Artigo em Inglês | MEDLINE | ID: mdl-35688894

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