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1.
J Wound Care ; 33(3): 156-164, 2024 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-38451788

RESUMO

OBJECTIVE: Pressure injuries (PIs) often develop in critically ill patients due to immobility, and underlying comorbidities that decrease tissue perfusion and wound healing capacity. This study sought to provide epidemiological data on determinants and current managements practices of PI in patients with COVID-19. METHOD: A US national insurance-based database consisting of patients with coronavirus or COVID-19 diagnoses was used for data collection. Patients were filtered by International Classification of Diseases (ICD) codes corresponding to coronavirus or COVID-19 diagnosis between 2019-2020. Diagnosis of PI following COVID-19 diagnosis was queried. Demographic data and comorbidity information was compared. Logistic regression analysis was used to determine predictors for both PI development and likelihood of operative debridement. RESULTS: A total of 1,477,851 patients with COVID-19 were identified. Of these, 15,613 (1.06%) subsequently developed a PI, and 8074 (51.7%) of these patients had an intensive care unit (ICU) admission. The average and median time between diagnosis of COVID-19 and PI was 39.4 and 26 days, respectively. PI was more likely to occur in patients with COVID-19 with: diabetes (odds ratio (OR): 1.39, 95% confidence interval (CI): 1.29-1.49; p<0.001); coronary artery disease (OR: 1.11, 95% CI: 1.04-1.18, p=0.002), hypertension (OR: 1.43, 95% CI: 1.26-1.64; p<0.001); chronic kidney disease (OR: 1.18, 95% CI: 1.10-1.26; p<0.001); depression (OR: 1.45, 95% CI 1.36-1.54; p<0.001); and long-term non-steroidal anti-inflammatory drug use (OR: 1.21, 95% CI: 1.05-1.40; p=0.007). They were also more likely in critically ill patients admitted to the ICU (OR: 1.40, 95% CI: 1.31-1.48; p<0.001); and patients requiring vasopressors (OR:1.25, 95% CI: 1.13-1.38; p<0.001), intubation (OR: 1.21, 95% CI 1.07-1.39; p=0.004), or with a diagnosis of sepsis (OR: 2.38, 95% CI 2.22-2.55; p<0.001). ICU admission, sepsis, buttock and lower back PI along with increasing Charlson Comorbidity Index (CCI) (OR: 1.04, 95% CI 1.00-1.08; p=0.043) was associated with surgical debridement. The vast majority of patients with COVID-19 did not undergo operative debridement or wound coverage. CONCLUSION: PIs are widely prevalent in patients with COVID-19, especially in those who are critically ill, yet the vast majority do not undergo operative procedures. DECLARATION OF INTEREST: The authors have no conflicts of interest to declare.


Assuntos
COVID-19 , Úlcera por Pressão , Sepse , Humanos , COVID-19/epidemiologia , Teste para COVID-19 , Úlcera por Pressão/epidemiologia , Estado Terminal , Unidades de Terapia Intensiva
2.
J Craniofac Surg ; 34(6): 1640-1643, 2023 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-37431904

RESUMO

Robin sequence is a congenital issue resulting in airway obstruction, difficulty feeding, and failure to thrive. Mandibular Distraction Osteogenesis is used to improve airway obstruction in these patients, but little data exists characterizing feeding outcomes following surgery. This study aims to evaluate feeding outcomes and weight gain following mandibular distraction for airway correction in infants. A single-center retrospective chart review was conducted, and patients under 12 months old who underwent mandibular distraction between December 2015 and July 2021 were included in the study. The presence of cleft palate, distance of distraction, and polysomnography results were recorded. The primary outcomes were the length of distraction, need for nasogastric tube or G-tube at discharge, time lapsed to achieve full oral feeds, and weight gain (kilogram). Ten patients met the criteria. Of those 10 patients, 4 were syndromic, 7 had a cleft palate, and 4 had a congenital cardiac diagnosis. The average length of stay postsurgery was 28 days. Eight patients achieved full oral feeds in an average of 65.6 days. Five patients required nasogastric tube or G-tube at discharge, with 3 of these patients later transitioning to full oral feeds. All patients gained weight 3 months postsurgery with an average of 0.521 kg/mo. Patients who achieved full oral feeds gained an average of 0.549 kg/mo. Patients with supplementation gained an average of 0.454 kg/mo. All patients demonstrated improvement in airway obstruction with an average postoperative apnea hypopnea index of 1.64. Further investigation is necessary to identify challenges seen in feeding after mandibular distraction osteogenesis and improve care.


Assuntos
Obstrução das Vias Respiratórias , Fissura Palatina , Osteogênese por Distração , Síndrome de Pierre Robin , Humanos , Lactente , Estudos Retrospectivos , Resultado do Tratamento , Mandíbula/cirurgia , Mandíbula/anormalidades , Obstrução das Vias Respiratórias/etiologia , Obstrução das Vias Respiratórias/cirurgia , Osteogênese por Distração/métodos , Síndrome de Pierre Robin/complicações , Síndrome de Pierre Robin/cirurgia , Aumento de Peso
3.
Ann Plast Surg ; 89(2): 207-213, 2022 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-35943228

RESUMO

BACKGROUND: Intraoperative fluorescence angiography (FA) has been described as a useful adjunct to physical examination in predicting mastectomy skin flap viability for immediate breast reconstruction. Its use has been described as a screening tool for mastectomy skin flap viability as well as a test used only for patients at high risk for mastectomy skin flap loss. We performed a national database review of implant-based breast reconstruction surgeries to determine the practice patterns of FA in this patient cohort and to determine if this technology impacted clinical outcomes. METHODS: A national insurance claims database was reviewed to select patients having undergone direct-to-implant (DTI) and immediate tissue expander (TE) placement with and without intraoperative FA as well as patients who had FA at the time of mastectomy without reconstruction. Patient characteristics that prompted FA and postoperative outcomes with and without FA were evaluated to determine its clinical impact in the observed practice pattern. RESULTS: Of the 48,464 patients identified, 836 had FA. More than twice as many patients undergoing DTI had FA than patients undergoing immediate TE placement (10.4% vs 5%, P < 0.0001). Twelve percent of patients receiving FA at the time of mastectomy had reconstruction delayed. Fluorescence angiography was associated with a trend toward lower overall complication rates in DTI patients (8.0% vs 11.9% without FA) but a significantly higher overall complication rate with immediate TE placement (13.8% vs 10.5% without FA, P = 0.018) and was associated with higher reoperation (12.0% vs 8.3% without FA, P = 0.037) in the TE group. There was no difference in other individual complications, readmission, or explantation for either clinical group with and without FA. Regression analysis identified obesity (odds ratio, 1.32; P < 0.001) and younger age (odds ratio, 1.74; P < 0.001) to be associated with performing FA, whereas obesity, diabetes, and tobacco use were associated with higher complication rates. CONCLUSIONS: Younger and otherwise healthier obese patients were more likely to have FA. A greater proportion of DTI patients had FA than TE patients with improved outcomes in the former group and worse outcomes in the latter group. Obesity, tobacco use, and diabetes were associated with worse outcomes, whereas only obesity was associated with FA use.


Assuntos
Implantes de Mama , Neoplasias da Mama , Mamoplastia , Implantes de Mama/efeitos adversos , Neoplasias da Mama/complicações , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/cirurgia , Feminino , Angiofluoresceinografia/efeitos adversos , Humanos , Mamoplastia/efeitos adversos , Mastectomia/efeitos adversos , Obesidade/complicações , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
4.
J Craniofac Surg ; 33(2): 517-520, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34643599

RESUMO

PURPOSE: Identifying which cranial defects among children warrant surgical repair is integral to providing adequate protection of the skull whereas minimizing exposure to surgical complications. This review examines the available evidence regarding the role of defect size in determining the appropriateness of nonsurgical versus surgical management. METHODS: An electronic literature review was performed using PubMed and Google Scholar to identify publications that provided rationales for nonsurgical management of cranial defects in the pediatric population based on size. Titles and abstracts were reviewed by the authors to determine eligibility for full-text analysis. Ineligible studies were categorized and relevant data from fully analyzed texts were recorded. RESULTS: Of the 523 articles that were reviewed, 500 were ineligible for full-text analysis due to the following most common reasons: no cranial defect described (227, 45%), did not discuss management of cranial defects (68, 14%), or surgery was performed on all defects in evaluation of a technique or protocol (86, 17%). Ten publications provided relevant data. The suggested size below which surgery was not recommended varied widely between articles. Beyond the age of 1 to 2 years, no general agreement on recommended management in children was found. Craniofacial surgeons had divergent views on the minimum diameter for a "critical" defect and the size for which surgical repair is necessary. CONCLUSIONS: Little guidance or consensus exists regarding the indications for surgical correction of cranial defects based on the size of the defect. Objective data is needed to classify "clinically critical defects" in the pediatric population.


Assuntos
Crânio , Criança , Pré-Escolar , Humanos , Lactente , Crânio/cirurgia
5.
Childs Nerv Syst ; 37(8): 2487-2495, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33779807

RESUMO

OVERVIEW: The goal of this study was to review the current application and status of three-dimensional printing for craniosynostosis surgery. METHODS: A literature review was performed using the PubMed/MEDLINE databases for studies published between 2010 and 2020. All studies demonstrating the utilization of three-dimensional printing for craniosynostosis surgery were included. RESULTS: A total of 15 studies were ultimately selected. This includes studies demonstrating novel three-dimensional simulation and printing workflows, studies utilizing three-dimensional printing for surgical simulation, as well as case reports describing prior experiences. CONCLUSION: The incorporation of three-dimensional printing into the domain of craniosynostosis surgery has many potential benefits. This includes streamlining surgical planning, developing patient-specific template guides, enhancing residency training, as well as aiding in patient counseling. However, the current state of the literature remains in the validation stage. Further study with larger case series, direct comparisons with control groups, and prolonged follow-up times is necessary before more widespread implementation is justified.


Assuntos
Craniossinostoses , Cirurgia Assistida por Computador , Craniossinostoses/diagnóstico por imagem , Craniossinostoses/cirurgia , Humanos , Impressão Tridimensional
6.
J Craniofac Surg ; 32(2): e182-e184, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33705068

RESUMO

ABSTRACT: Palatal fistulae are common complications of cleft palate surgery with a frequency of 5% to 29% and are challenging to repair. Optimal timing to repair palatal fistulae, in a staged fashion before alveolar bone grafting, or at the same time, still remains controversial. The primary aim of this study is to compare outcomes of 2 groups with regard to successful alveolar bone grafting in patients with cleft lip and palate and palatal fistulae. We describe a review of 85 consecutive patients identified as undergoing bone grafting from a single institution craniofacial team during 2003 to 2018. Twenty-eight required palatal fistula repair. All patients had a diagnosis of unilateral or bilateral complete cleft lip and palate. Patients with cleft lip and palate repairs were stratified based on preoperative or simultaneous palatal fistula repair. Panoramic radiographs were reviewed by 2 physicians to evaluate success of bone grafting. Comparison between cohorts was made by statistical analysis. Of the 28 that required palatal fistula repair, 15 (53.6%) patients underwent prebone grafting palatal fistula repair and 13 (46.4%) patients underwent simultaneous bone grafting with palatal fistula repair. Mean age at time of bone grafting and palatal fistula repair were 10.60 years old and 9.39 years old, respectively. Length to follow-up was 54.82 months. The average height of the healed alveolar cleft site for patients in the prebone grafting or simultaneous groups was 10.57 mm and 11.46 mm, respectively. Patients who underwent palatal fistula repair and simultaneous bone grafting had similar outcomes as those with palatal fistula repair preoperatively.


Assuntos
Enxerto de Osso Alveolar , Fenda Labial , Fissura Palatina , Fístula , Criança , Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Humanos , Estudos Retrospectivos
7.
J Craniofac Surg ; 31(3): 794-795, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31934977

RESUMO

Management of posterior table fractures has seen a conservative shift in recent years. Patients who present with CSF leak may be safely monitored, while cranialization is reserved for patients with severe comminuted or displaced posterior table fractures. We report the case of a 20-year-old patient with a comminuted, displaced posterior table fracture that was missing a central segment and was associated with dural injury. The septum and contralateral sinus were unaffected, thus warranting unilateral cranialization. This is a reported case of hemicranialization, which falls on the spectrum of a conservative approach. At 12 months post-op, the patient has not experienced any complications historically associated with cranialization including persistent CSF leak, meningitis, wound infection, alopecia or facial nerve injury at the site of surgery.


Assuntos
Fraturas Cominutivas/cirurgia , Seio Frontal/cirurgia , Fraturas Cranianas/cirurgia , Traumatismos Faciais/cirurgia , Fraturas Cominutivas/diagnóstico por imagem , Seio Frontal/diagnóstico por imagem , Humanos , Masculino , Fraturas Cranianas/diagnóstico por imagem , Adulto Jovem
8.
J Craniofac Surg ; 31(8): 2273-2275, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33136869

RESUMO

The objective of this study is to validate the proof of concept of a 3-dimensional (3D)-printed temporal mandibular joint (TMJ) for use in mandibular distraction in patients with severe craniofacial microsomia (CFM). Patients with Pruzansky-Kaban IIB and III have severe condylar dysplasia and abnormal or absent TMJs, often resulting in upper airway obstruction during infancy. As these patients progress, they require subsequent surgeries to correct facial asymmetry and TMJ function. While studies have shown promising outcomes with costochondral grafting or mandibular distraction without a TMJ in the setting of patients with Pruzansky-Kaban IIB and III it is often unsuccessful in avoiding tracheostomy during infancy. Using an adult head and neck cadaver, the right condylar head was removed to emulate a Pruzansky-Kaban III mandible. A 3D model of an adult skull was obtained. The 3D TMJ was replaced into the cadaver and KLS distractor applied in the vertical orientation. The authors achieved adequate distraction using a 3D-printed TMJ. The 3D structure developed here can potentially be used for clinical application in CFM patients with absent or rudimentary TMJ for distraction and further avoidance of the need for tracheostomy for airway obstruction.


Assuntos
Síndrome de Goldenhar/diagnóstico por imagem , Doenças Mandibulares/diagnóstico por imagem , Idoso , Assimetria Facial/cirurgia , Síndrome de Goldenhar/cirurgia , Humanos , Imageamento Tridimensional , Doenças Mandibulares/cirurgia , Traqueostomia
9.
J Craniofac Surg ; 31(4): 1018-1021, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32433138

RESUMO

PURPOSE: Trainee exposure to craniofacial pathology can be limited due to rare disease presentation, revealing a need for tools that assist in visualizing complex 3D pathologic anatomy. 3D-printed models show potential as a useful aid, allowing for physical manipulation and hands-on experience. This study investigates their educational value in teaching craniofacial pathology and surgical repair. METHODS: Forty-four medical students randomly assigned to a control group or model group were given a PowerPoint presentation-based module on craniosynostosis and surgical repair. The model group was also provided with 3D-printed models of sagittal, metopic, and bicoronal synostosis, created using patient-specific preoperative computed tomography data. A survey using the Likert scale evaluated participants' learning experience. Pre- and postmodule scores on a 10-question multiple choice quiz were recorded. RESULTS: The survey showed that students in the model group reported better understanding of the anatomy (4.86 ±â€Š0.15 versus 4.26 ±â€Š0.22; P = 0.0001) and visualization of the pathology (4.76 ±â€Š0.23 versus 4.26 ±â€Š0.25; P = 0.0064), gaining an improved understanding of surgical approach (4.38 ±â€Š0.37 versus 3.83 ±â€Š0.29; P = 0.0266), which was more effectively taught (4.24 ±â€Š0.33 versus 3.30 ±â€Š0.38; P = 0.0007) with the 3D-printed models. The mean pre- and post-module quiz scores between groups were similar. CONCLUSION: 3D-printed models demonstrated an improved learning experience for medical students as shown by survey. These findings suggest a potential use for 3D-printed models in medical education of craniofacial pathology and surgery.


Assuntos
Impressão Tridimensional , Cirurgia Plástica/educação , Craniossinostoses/cirurgia , Educação Médica , Imageamento Tridimensional , Aprendizagem , Modelos Anatômicos , Estudantes de Medicina , Tomografia Computadorizada por Raios X
10.
J Craniofac Surg ; 30(2): 529-531, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30550440

RESUMO

Appropriate management of lower 3rd molars is crucial to successful treatment of mandibular angle fractures. A unique case of a patient who presented for initial management of a left mandibular angle fracture with an unerupted lower 3rd molar was discussed in this study. After treatment with open reduction and internal fixation of the fracture, the lower 3rd molar erupted and the patient subsequently developed fungal osteomyelitis and hardware failure. This was successfully treated with hardware removal, maxillomandibular fixation, and combined use of an intravenous antibiotic and oral antifungal.


Assuntos
Candida albicans/isolamento & purificação , Candidíase/etiologia , Fixação Interna de Fraturas/efeitos adversos , Fraturas Mandibulares/cirurgia , Dente Serotino , Complicações Pós-Operatórias/microbiologia , Erupção Dentária , Placas Ósseas , Humanos , Técnicas de Fixação da Arcada Osseodentária , Masculino , Mandíbula , Pessoa de Meia-Idade , Micoses/etiologia , Redução Aberta/efeitos adversos , Osteomielite/microbiologia
11.
J Craniofac Surg ; 30(2): 339-341, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31137450

RESUMO

PURPOSE: A significant challenge in surgical education is to provide a meaningful hands-on experience with the pathology the trainee will see in independent practice. Craniofacial anatomy is challenging and unfamiliar to the learner. METHODS: Using preoperative computed tomography data, the authors produced an accurately sized, three-dimensional (3D) printed model of the congenital craniofacial anatomy of patients treated by the same attending surgeon-PGY4 resident surgeon pair over the course of a 6-month rotation. A preoperative stepwise surgical plan was written by the attending and resident, and the plan was marked on the 3D model by the attending and resident separately. The written and marked plans were measured for accuracy and time to completion. The resident surgeon's applicable milestone levels were assessed. RESULTS: Seven congenital craniofacial anomalies met criteria for inclusion: 4 craniosynostosis cases, 2 mandibular distractions, and 1 LeFort I distraction. The number of inaccuracies of the written plan improved from 5 to 0 for sagittal synostosis and 4 to 0 for mandibular distraction. The time to complete the written plan decreased by 22% for sagittal synostosis and 45% for mandibular distraction. The number of inaccuracies of the marked plan decreased from 5 to 0 for sagittal synostosis and 2 to 0 for mandibular distraction. Time to completion of the marked plan decreased by 76% for sagittal synostosis and 50% for mandibular distraction. Milestone scores increased an average of 1.875 levels. CONCLUSION: Three-dimensional printed craniofacial models are a positive addition to resident training and have been objectively quantified to improve the accuracy and time to completion of the surgical plan as well as progression in the plastic surgery milestones.


Assuntos
Craniossinostoses/cirurgia , Internato e Residência/métodos , Modelos Anatômicos , Impressão Tridimensional , Cirurgia Plástica/educação , Cefalometria , Humanos , Mandíbula/cirurgia , Procedimentos de Cirurgia Plástica/educação , Procedimentos de Cirurgia Plástica/métodos , Tomografia Computadorizada por Raios X
12.
Ann Plast Surg ; 80(6S Suppl 6): S395-S397, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29762435

RESUMO

Insurance authorization of reduction mammoplasty can be a challenging process. Despite copious evidence of the benefits of this operation and evidence that specimen weight does not correlate with symptomatic relief, most insurance providers require estimated resection weights. Many formulas and techniques to predict resection weight are inconsistent or not specific to the vertical technique. This study describes a simple method for generating a surgeon-specific equation for accurately predicting vertical reduction mammoplasty resection weight using 2 breast surface measurements.


Assuntos
Mama/anatomia & histologia , Mamoplastia , Cuidados Pré-Operatórios/métodos , Adolescente , Adulto , Idoso , Mama/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Tamanho do Órgão , Estudos Retrospectivos , Adulto Jovem
13.
J Craniofac Surg ; 29(4): 946-948, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29489577

RESUMO

A unilateral deficit in velopharyngeal closure during speech production is an unusual presentation of velopharyngeal dysfunction (VPD) and few solutions have been described for this problem. This report details the long-term outcomes using this technique. We performed a retrospective chart review of all the patients who underwent a unilateral Orticochea pharyngoplasty for VPD. The authors identified 10 patients treated with 11 unilateral pharyngoplasty at a single tertiary care institutional setting. The mean age at repair was 8.6 years. The mean length of follow-up was 7.6 years. All the patients demonstrated improvement in velopharyngeal closure and speech resonance with 4 showing complete resolution of VPD. There were no revisions required or complications. One patient, after 10.7 years, required a unilateral procedure on the contralateral side which resulted in complete resolution of VPD postoperatively.


Assuntos
Procedimentos Cirúrgicos Bucais , Faringe/cirurgia , Insuficiência Velofaríngea/cirurgia , Criança , Humanos , Estudos Retrospectivos , Fala , Resultado do Tratamento
14.
Cleft Palate Craniofac J ; 55(3): 356-361, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29437511

RESUMO

OBJECTIVE: The objective of this study was to validate the proof of concept of a computer-simulated cranial distraction, demonstrating accurate shape and end volume. DESIGN: Detailed modeling was performed on pre- and postoperative computed tomographic (CT) scans to generate accurate measurements of intracranial volume. Additionally, digital distraction simulations were performed on the preoperative scan and the resultant intracranial volume and shape were evaluated. SETTING: Tertiary Children's Hospital. PATIENTS, PARTICIPANTS: Preoperative and postoperative CT images were used from 10 patients having undergone cranial distraction for cephalocranial disproportion. INTERVENTIONS: None; computer simulation. MAIN OUTCOME MEASURE: Computer simulation feasibility of cranial vault distraction was demonstrated through creation of digital osteotomies, simulating distraction through translating skull segments, followed by simulated consolidation. Accuracy of the model was evaluated through comparing the intracranial volumes of actual and simulated distracted skulls. RESULTS: The developed digital distraction simulation was performed on the CT images of 10 patients. Plotting the relationship between the actual and simulated postdistraction volumes for the 10 patients yielded a slope of 1.0 and a correlation coefficient of 0.99. The average actual resultant volume change from distraction was 77.0 mL, compared to a simulated volume change of 76.9 mL. CONCLUSIONS: Digital simulation of cranial distraction was demonstrated through manipulation of the CT images and confirmed by comparing the actual to simulated volume change. This process may provide objective data in designing an individual distraction plan to optimize volume expansion and resultant cranial shape as well as patient education.


Assuntos
Simulação por Computador , Craniossinostoses/diagnóstico por imagem , Craniossinostoses/cirurgia , Osteogênese por Distração/métodos , Crânio/anormalidades , Cirurgia Assistida por Computador , Tomografia Computadorizada por Raios X , Pré-Escolar , Feminino , Humanos , Imageamento Tridimensional , Lactente , Recém-Nascido , Masculino , Estudo de Prova de Conceito , Resultado do Tratamento
15.
Ann Plast Surg ; 78(6S Suppl 5): S311-S314, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28272149

RESUMO

INTRODUCTION: Correction of auricular deformities can be accomplished through splinting within the first few weeks of life. This is hypothesized to be due to retained circulating maternal estrogens decreasing the structural density of collagen; however, this has not been fully tested. Cartilage elasticity is dependent on the concentration of the proteoglycan aggregate, and hyaluronic acid, a constituent of proteoglycan aggregate, is increased by estrogens. Nonsurgical correction of these deformities in more developed patients has the potential to change clinical practice and eliminate surgical risks. Previous studies have demonstrated preliminary promise with the use of injectable estrogen to treat auricular deformities. For this study, we have validated an animal model and demonstrated the feasibility of a more therapeutically appropriate topical estrogen treatment in restoring neonatal plasticity of auricular cartilage. METHODS: Ears of 12 New Zealand rabbits were folded and splinted, and assigned an experimental group (estrogen, placebo, and untreated control) (n = 8 ears). Treatment ears received topical estrogen or placebo cream daily for 4 weeks, whereas controls received no treatment. The splints were removed following 2 additional weeks, and photographs were taken to calculate the retained fold angle. Biopsies were also taken for histologic analysis. RESULTS: The 8 control ears showed a statistically increased angle from a folded orientation of 46.6 degrees to return of ear position to a normal upright position of 151.2 degrees by the fourth day after splint removal. Both the estrogen-treated and placebo-treated ears responded to splinting with maintained folding (36.6 degrees and 32.5 degrees, respectively). Auricular cartilage thickness trended toward thicker in ears treated with estrogen, consistent with increased matrix components. CONCLUSIONS: Estrogen and placebo treatment with splinting of ears lead to a significant change to the cartilage configuration, validating the model. The results of this study are very encouraging and provide the foundation for a noninvasive therapeutic approach for correcting auricular deformities. Future work will include a more detailed mechanistic study evaluating the dosing of estrogen and the efficiency of dermal penetration as well as evaluating the long-term outcomes and molecular mechanism-associated cartilaginous responses to estrogen.


Assuntos
Cartilagem da Orelha/efeitos dos fármacos , Cartilagem da Orelha/patologia , Estrogênios/farmacologia , Contenções , Administração Tópica , Animais , Biópsia por Agulha , Plasticidade Celular/efeitos dos fármacos , Pavilhão Auricular/cirurgia , Cartilagem da Orelha/cirurgia , Imuno-Histoquímica , Masculino , Modelos Animais , Coelhos , Distribuição Aleatória , Valores de Referência
16.
J Craniofac Surg ; 28(8): 2053-2055, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28930929

RESUMO

Craniofacial microsomia (CFM) is a common craniofacial anomaly characterized by asymmetric malformation of the mandible, ear, and other structures including the upper airway. The degree of mandibular hypoplasia is classified using a scheme developed by Pruzansky and modified by Kaban. Severe condylar dysplasia is the hallmark of Pruzansky-Kaban types IIB and III. Distraction osteogenesis has emerged as a treatment modality for mandibular hypoplasia in this setting for the treatment of asymmetry and airway obstruction. However, its use to resolve upper airway obstruction and avoid tracheostomy in infants with types IIB and III is not reported in the literature. The authors present a patient with successful distraction osteogenesis in a patient with CFM resulting in a Pruzansky IIB micrognathia. The authors achieved resolution of upper airway obstruction and avoidance of tracheostomy.


Assuntos
Obstrução das Vias Respiratórias/cirurgia , Síndrome de Goldenhar/complicações , Síndrome de Goldenhar/cirurgia , Mandíbula/cirurgia , Osteogênese por Distração , Obstrução das Vias Respiratórias/etiologia , Humanos , Lactente , Masculino , Mandíbula/anormalidades , Micrognatismo/cirurgia , Osteogênese por Distração/métodos , Traqueostomia
17.
J Craniofac Surg ; 27(6): 1501-5, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27428903

RESUMO

PURPOSE: Cephalocranial disproportion is a symptomatic condition related to a volume discrepancy between the calvarial vault and the brain. Traditional expansion techniques are unfavorable in older children due to inadequate dural ossification, lack of bone pliability, and limited future growth potential. The authors review their experience using distraction to close bone defects in this setting. METHODS: A retrospective analysis was performed of all patients treated using distraction in this setting by a single surgeon. Demographic and outcomes data were collected. The efficacy of ossification of bone defects after expansion by distraction was measured using volume analysis of three-dimensional computed tomography (CT) scans. This required a CT scan at the completion of device activation and a follow-up CT scan 6 months or more beyond activation. RESULTS: Sixteen patients (17 distractions) met the imaging-based inclusion criteria. The average age at surgery was 3.97 (2.14-6.89) years. The mean initial bone defect volume after asymmetric transverse distraction was 7.26 (5.45-13.73) mL. The mean final defect volume was 2.18 (0.00-5.90) mL with a mean change of 5.08 (1.21-12.79) mL and mean interval time of 27.85 (7.13-56.39) months. This represents a mean percent defect closure of 72.30 (20.38-100.00). CONCLUSION: Distraction osteogenesis is a very effective tool for treating the older child with cephalocranial disproportion. The ability to ossify the bone defects without a donor site provides a considerable advantage in these patients.


Assuntos
Osteogênese por Distração , Crânio , Criança , Pré-Escolar , Humanos , Estudos Retrospectivos , Crânio/anormalidades , Crânio/diagnóstico por imagem , Crânio/cirurgia , Tomografia Computadorizada por Raios X
18.
J Craniofac Surg ; 27(3): 565-70, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26999694

RESUMO

Malformations of the craniofacial skeleton are common. Restoration of anatomic shape, size, and position has been traditionally accomplished using autologous bone grafting to fill gaps created by surgery and segmental movement. The authors present their practice using distraction in many different ages and settings over 20 years. A retrospective review was performed of all craniofacial patients treated using distraction osteogenesis for mandible, midface, and calvarium. The authors identified 205 patient. Mandible: 112 patients were treated at an average age of 3.4 years. 18.8% of patients required repeat distraction. There was no difference in the neonatal versus older group (P = 0.71). There were significantly higher reoperation rates in syndromic children (P < 0.01). Midface: 58 patients underwent Lefort III distraction at an average age of 13.6 years. One (1.7%) required repeat distraction (Miller syndrome). Five (8.6%) patients underwent subsequent Lefort I advancement for occlusal changes. Calvarium: 33 patients were treated at an average age of 4.7 years. No repeat distractions were performed. One patient required an additional advancement procedure. Distraction demonstrates successful long-term correction of defects in the craniofacial skeleton with the versatility and control needed to treat the wide spectrum of deformity.


Assuntos
Anormalidades Craniofaciais/cirurgia , Mandíbula/cirurgia , Osteogênese por Distração/métodos , Crânio/cirurgia , Adolescente , Adulto , Criança , Pré-Escolar , Anormalidades Craniofaciais/diagnóstico , Feminino , Humanos , Lactente , Masculino , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Adulto Jovem
19.
J Hand Surg Am ; 40(9): 1755-63, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26163923

RESUMO

PURPOSE: To describe the technique and results of the tapered M-to-V flap for syndactyly web space construction. METHODS: We reviewed a single-surgeon, single-institution experience of all syndactyly reconstructions performed between 1982 and 2013. Demographic data and patient characteristics were recorded. Complications included flap loss, graft loss, web creep, infection, restricted range of motion, and digit deviation. RESULTS: A total of 138 web spaces were reconstructed in 93 patients. There were 89 primary congenital hand and 32 foot syndactylies. Four patients had an acquired simple incomplete syndactyly and 13 patients had secondary reconstructions. The complication rate was 14%. The most common complication was web creep resulting from partial skin graft loss (12 web spaces; 9%). There were no total flap losses. Univariate analysis revealed no factor to be predictive of an elevated complication rate. Average follow-up was 2.6 years (range, 6 mo to 26 y). CONCLUSIONS: The tapered M-to-V flap proved to be a reliable and versatile technique for web space reconstruction, offering several advantages over the standard rectangular flap method of repair, such as ease of intraoperative adjustment, a z-plasty at the palmodigital crease to minimize scar contracture, and better color match. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.


Assuntos
Dedos/anormalidades , Procedimentos de Cirurgia Plástica/métodos , Retalhos Cirúrgicos , Sindactilia/cirurgia , Dedos do Pé/anormalidades , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Resultado do Tratamento
20.
J Craniofac Surg ; 26(1): e16-8, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25565236

RESUMO

Osteogenesis imperfecta (OI) is an inherited disorder characterized by bone fragility and deformity. The craniofacial skeleton may be involved either primarily or by result of a concomitant diagnosis. Distraction osteogenesis has emerged as a versatile reconstructive option for many craniofacial deformities. Mandibular lengthening by distraction has not been reported in a patient with OI. We present a patient in whom mandibular lengthening was successfully performed twice for hemifacial microsomia. Bilateral lengthening was initially performed with successful airway improvement. This was followed by transport distraction on the more severely affected side for condylar reconstruction. Successful mandibular lengthening by distraction is possible in the setting of OI.


Assuntos
Mandíbula/cirurgia , Micrognatismo/cirurgia , Osteogênese Imperfeita/cirurgia , Osteogênese por Distração/métodos , Procedimentos de Cirurgia Plástica/métodos , Humanos , Lactente , Masculino , Resultado do Tratamento
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