Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee, Gina; Zheng, Yuxiang; Cho, Sungyun; Jang, Cholsoon; England, Christina; Dempsey, Jamie M; Yu, Yonghao; Liu, Xiaolei; He, Long; Cavaliere, Paola M; Chavez, Andre; Zhang, Erik; Isik, Meltem; Couvillon, Anthony; Dephoure, Noah E; Blackwell, T Keith; Yu, Jane J; Rabinowitz, Joshua D; Cantley, Lewis C; Blenis, John.

Cell ; 171(7): 1545-1558.e18, 2017 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-29153836

2.

Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging.

Castillo-Quan, Jorge Iván; Blackwell, T Keith.

Cell ; 167(7): 1670-1671, 2016 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-27984715

3.

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics.

Campos, Juliane Cruz; Marchesi Bozi, Luiz Henrique; Krum, Barbara; Grassmann Bechara, Luiz Roberto; Ferreira, Nikolas Dresch; Arini, Gabriel Santos; Albuquerque, Rudá Prestes; Traa, Annika; Ogawa, Takafumi; van der Bliek, Alexander M; Beheshti, Afshin; Chouchani, Edward T; Van Raamsdonk, Jeremy M; Blackwell, T Keith; Ferreira, Julio Cesar Batista.

Proc Natl Acad Sci U S A ; 120(2): e2204750120, 2023 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-36595699

4.

nhl-2 Modulates microRNA activity in Caenorhabditis elegans.

Hammell, Christopher M; Lubin, Isabella; Boag, Peter R; Blackwell, T Keith; Ambros, Victor.

Cell ; 136(5): 926-38, 2009 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-19269369

5.

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.

Hourihan, John M; Moronetti Mazzeo, Lorenza E; Fernández-Cárdenas, L Paulette; Blackwell, T Keith.

Mol Cell ; 63(4): 553-566, 2016 08 18.

Artigo em Inglês | MEDLINE | ID: mdl-27540856

6.

Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.

Tataridas-Pallas, Nikolaos; Thompson, Maximillian A; Howard, Alexander; Brown, Ian; Ezcurra, Marina; Wu, Ziyun; Silva, Isabel Goncalves; Saunter, Christopher D; Kuerten, Timo; Weinkove, David; Blackwell, T Keith; Tullet, Jennifer M A.

PLoS Genet ; 17(3): e1009358, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33661901

7.

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling.

Campos, Juliane C; Wu, Ziyun; Rudich, Paige D; Soo, Sonja K; Mistry, Meeta; Ferreira, Julio Cb; Blackwell, T Keith; Van Raamsdonk, Jeremy M.

EMBO Rep ; 22(12): e52964, 2021 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-34617666

8.

OMA-gosh, where's that TAF?

Blackwell, T Keith; Walker, Amy K.

Cell ; 135(1): 18-20, 2008 Oct 03.

Artigo em Inglês | MEDLINE | ID: mdl-18854150

9.

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.

Tullet, Jennifer M A; Hertweck, Maren; An, Jae Hyung; Baker, Joseph; Hwang, Ji Yun; Liu, Shu; Oliveira, Riva P; Baumeister, Ralf; Blackwell, T Keith.

Cell ; 132(6): 1025-38, 2008 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-18358814

10.

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity.

Castillo-Quan, Jorge Iván; Tain, Luke S; Kinghorn, Kerri J; Li, Li; Grönke, Sebastian; Hinze, Yvonne; Blackwell, T Keith; Bjedov, Ivana; Partridge, Linda.

Proc Natl Acad Sci U S A ; 116(42): 20817-20819, 2019 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-31570569

11.

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.

Ewald, Collin Y; Landis, Jess N; Porter Abate, Jess; Murphy, Coleen T; Blackwell, T Keith.

Nature ; 519(7541): 97-101, 2015 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-25517099

12.

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Wu, Ziyun; Senchuk, Megan M; Dues, Dylan J; Johnson, Benjamin K; Cooper, Jason F; Lew, Leira; Machiela, Emily; Schaar, Claire E; DeJonge, Heather; Blackwell, T Keith; Van Raamsdonk, Jeremy M.

BMC Biol ; 16(1): 147, 2018 12 18.

Artigo em Inglês | MEDLINE | ID: mdl-30563508

13.

Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling.

Ewald, Collin Yvès; Castillo-Quan, Jorge Iván; Blackwell, T Keith.

Gerontology ; 64(1): 96-104, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-28934747

14.

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

Yoon, John C; Ling, Alvin J Y; Isik, Meltem; Lee, Dong-Young Donna; Steinbaugh, Michael J; Sack, Laura M; Boduch, Abigail N; Blackwell, T Keith; Sinclair, David A; Elledge, Stephen J.

Proc Natl Acad Sci U S A ; 111(10): 3781-6, 2014 Mar 11.

Artigo em Inglês | MEDLINE | ID: mdl-24556985

15.

Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.

Glover-Cutter, Kira M; Lin, Stephanie; Blackwell, T Keith.

PLoS Genet ; 9(9): e1003701, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-24068940

16.

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development.

Ruf, Vanessa; Holzem, Christina; Peyman, Tobias; Walz, Gerd; Blackwell, T Keith; Neumann-Haefelin, Elke.

Dev Biol ; 384(2): 214-27, 2013 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-23973804

17.

Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.

Li, Xuan; Matilainen, Olli; Jin, Congyu; Glover-Cutter, Kira M; Holmberg, Carina I; Blackwell, T Keith.

PLoS Genet ; 7(6): e1002119, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21695230

18.

RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

Wang, Jinling; Robida-Stubbs, Stacey; Tullet, Jennifer M A; Rual, Jean-François; Vidal, Marc; Blackwell, T Keith.

PLoS Genet ; 6(8)2010 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-20700440

19.

An antisteatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement.

Castillo-Quan, Jorge Iván; Steinbaugh, Michael J; Fernández-Cárdenas, Laura Paulette; Pohl, Nancy K; Wu, Ziyun; Zhu, Feimei; Moroz, Natalie; Teixeira, Veronica; Bland, Monet S; Lehrbach, Nicolas J; Moronetti, Lorenza; Teufl, Magdalena; Blackwell, T Keith.

Sci Adv ; 9(1): eadc8917, 2023 Jan 04.

Artigo em Inglês | MEDLINE | ID: mdl-36598980

20.

S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects.

Ogawa, Takafumi; Masumura, Koji; Kohara, Yuki; Kanai, Muneyoshi; Soga, Tomoyoshi; Ohya, Yoshikazu; Blackwell, T Keith; Mizunuma, Masaki.

Aging Cell ; 21(5): e13604, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35388610

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