Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

From the European Medicines Agency to Project Orbis: new activities and challenges to facilitate UK oncology drug approval following Brexit.

Lythgoe, Mark P; Krell, Jonathan; Bower, Mark; Murphy, Ravindhi; Marriott, John; Blagden, Sarah P; Aggarwal, Ajay; Sullivan, Richard.

Lancet Oncol ; 24(4): e150-e160, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36990613

2.

Additional consensus recommendations for conducting complex innovative trials of oncology agents: a post-pandemic perspective.

Blagden, Sarah P; Yu, Ly-Mee; Ellis, Stephanie; Hughes, Helen; Shaaban, Abeer; Fennelly-Barnwell, Jonathan; Lythgoe, Mark P; Cooper, Alison M; Maignen, Francois M; Buckland, Sean W; Kearns, Pamela R; Brown, Louise C.

Br J Cancer ; 128(3): 474-477, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36434156

3.

Phase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumors.

Luke, Jason J; Fakih, Marwan; Schneider, Charles; Chiorean, E Gabriela; Bendell, Johanna; Kristeleit, Rebecca; Kurzrock, Razelle; Blagden, Sarah P; Brana, Irene; Goff, Laura W; O'Hayer, Kevin; Geschwindt, Ryan; Smith, Michael; Zhou, Feng; Naing, Aung.

Br J Cancer ; 128(12): 2227-2235, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37087488

4.

A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer.

Kristeleit, Rebecca; Plummer, Ruth; Jones, Robert; Carter, Louise; Blagden, Sarah; Sarker, Debashis; Arkenau, Tobias; Evans, Thomas R Jeffry; Danson, Sarah; Symeonides, Stefan N; Veal, Gareth J; Klencke, Barbara J; Kowalski, Mark M; Banerji, Udai.

Br J Cancer ; 129(1): 38-45, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37120671

5.

The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.

Smith, Ewan M; Benbahouche, Nour El Houda; Morris, Katherine; Wilczynska, Ania; Gillen, Sarah; Schmidt, Tobias; Meijer, Hedda A; Jukes-Jones, Rebekah; Cain, Kelvin; Jones, Carolyn; Stoneley, Mark; Waldron, Joseph A; Bell, Cameron; Fonseca, Bruno D; Blagden, Sarah; Willis, Anne E; Bushell, Martin.

Nucleic Acids Res ; 49(1): 458-478, 2021 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-33332560

6.

Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment (ICON8): overall survival results from an open-label, randomised, controlled, phase 3 trial.

Clamp, Andrew R; James, Elizabeth C; McNeish, Iain A; Dean, Andrew; Kim, Jae-Won; O'Donnell, Dearbhaile M; Gallardo-Rincon, Dolores; Blagden, Sarah; Brenton, James; Perren, Tim J; Sundar, Sudha; Lord, Rosemary; Dark, Graham; Hall, Marcia; Banerjee, Susana; Glasspool, Rosalind M; Hanna, C Louise; Williams, Sarah; Scatchard, Kate M; Nam, Helena; Essapen, Sharadah; Parkinson, Christine; McAvan, Lucy; Swart, Ann Marie; Popoola, Babasola; Schiavone, Francesca; Badrock, Jonathan; Fananapazir, Fuad; Cook, Adrian D; Parmar, Mahesh; Kaplan, Richard; Ledermann, Jonathan A.

Lancet Oncol ; 23(7): 919-930, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35690073

7.

Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.

Di Giovannantonio, Matteo; Harris, Benjamin Hl; Zhang, Ping; Kitchen-Smith, Isaac; Xiong, Lingyun; Sahgal, Natasha; Stracquadanio, Giovanni; Wallace, Marsha; Blagden, Sarah; Lord, Simon; Harris, David; Harris, Adrian H L; Buffa, Francesca M; Bond, Gareth L.

J Med Genet ; 58(6): 392-399, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-32591342

8.

Controversies around the function of LARP1.

Berman, Andrea J; Thoreen, Carson C; Dedeic, Zinaida; Chettle, James; Roux, Philippe P; Blagden, Sarah P.

RNA Biol ; 18(2): 207-217, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-32233986

9.

LARP1 isoform expression in human cancer cell lines.

Schwenzer, Hagen; Abdel Mouti, Mai; Neubert, Pia; Morris, Josephine; Stockton, Joanne; Bonham, Sarah; Fellermeyer, Martin; Chettle, James; Fischer, Roman; Beggs, Andrew D; Blagden, Sarah P.

RNA Biol ; 18(2): 237-247, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-32286153

10.

NICE public health guidance update.

Blagden, Sarah; Austin, Catrin; Richey, Roberta; Desai, Monica.

J Public Health (Oxf) ; 43(1): e107-e109, 2021 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-33423063

11.

Weekly platinum-based chemotherapy versus 3-weekly platinum-based chemotherapy for newly diagnosed ovarian cancer (ICON8): quality-of-life results of a phase 3, randomised, controlled trial.

Blagden, Sarah P; Cook, Adrian D; Poole, Christopher; Howells, Lesley; McNeish, Ian A; Dean, Andrew; Kim, Jae-Weon; O'Donnell, Dearbhaile M; Hook, Jane; James, Elizabeth C; White, Ian R; Perren, Timothy; Lord, Rosemary; Dark, Graham; Earl, Helena M; Hall, Marcia; Kaplan, Richard; Ledermann, Jonathan A; Clamp, Andrew R.

Lancet Oncol ; 21(7): 969-977, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32615110

12.

Effective delivery of Complex Innovative Design (CID) cancer trials-A consensus statement.

Blagden, Sarah P; Billingham, Lucinda; Brown, Louise C; Buckland, Sean W; Cooper, Alison M; Ellis, Stephanie; Fisher, Wendy; Hughes, Helen; Keatley, Debbie A; Maignen, Francois M; Morozov, Alex; Navaie, Will; Pearson, Sarah; Shaaban, Abeer; Wydenbach, Kirsty; Kearns, Pamela R.

Br J Cancer ; 122(4): 473-482, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31907370

13.

Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal carcinoma treatment (ICON8): primary progression free survival analysis results from a GCIG phase 3 randomised controlled trial.

Clamp, Andrew R; James, Elizabeth C; McNeish, Iain A; Dean, Andrew; Kim, Jae-Weon; O'Donnell, Dearbhaile M; Hook, Jane; Coyle, Christopher; Blagden, Sarah; Brenton, James D; Naik, Raj; Perren, Tim; Sundar, Sudha; Cook, Adrian D; Gopalakrishnan, Gosala S; Gabra, Hani; Lord, Rosemary; Dark, Graham; Earl, Helena M; Hall, Marcia; Banerjee, Susana; Glasspool, Rosalind M; Jones, Rachel; Williams, Sarah; Swart, Ann Marie; Stenning, Sally; Parmar, Mahesh; Kaplan, Richard; Ledermann, Jonathan A.

Lancet ; 394(10214): 2084-2095, 2019 12 07.

Artigo em Inglês | MEDLINE | ID: mdl-31791688

14.

A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: the Ipi-Glio trial protocol.

Brown, Nicholas F; Ng, Stasya M; Brooks, Claire; Coutts, Tim; Holmes, Jane; Roberts, Corran; Elhussein, Leena; Hoskin, Peter; Maughan, Tim; Blagden, Sarah; Mulholland, Paul.

BMC Cancer ; 20(1): 198, 2020 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-32164579

15.

A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours.

Mak, Gabriel; Soria, Jean-Charles; Blagden, Sarah P; Plummer, Ruth; Fleming, Ronald A; Nebot, Noelia; Zhang, Jianping; Mazumdar, Jolly; Rogan, Debra; Gazzah, Anas; Rizzuto, Ivana; Greystoke, Alastair; Yan, Li; Tolson, Jerry; Auger, Kurt R; Arkenau, Hendrik-Tobias.

Br J Cancer ; 120(10): 975-981, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30992546

16.

Meningococcal vaccination in primary care amongst adolescents in North West England: an ecological study investigating associations with general practice characteristics.

Blagden, Sarah; Hungerford, Daniel; Limmer, Mark.

J Public Health (Oxf) ; 41(1): 149-157, 2019 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-29385512

17.

UK oncology approvals in 2022: global regulatory collaboration and new regulatory pathways deliver new anti-cancer therapies.

Lythgoe, Mark P; Sullivan, Richard; Blagden, Sarah.

Lancet Oncol ; 24(9): 963-966, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37657470

18.

Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study.

Blagden, Sarah P; Rizzuto, Ivana; Suppiah, Puvan; O'Shea, Daniel; Patel, Markand; Spiers, Laura; Sukumaran, Ajithkumar; Bharwani, Nishat; Rockall, Andrea; Gabra, Hani; El-Bahrawy, Mona; Wasan, Harpreet; Leonard, Robert; Habib, Nagy; Ghazaly, Essam.

Br J Cancer ; 119(7): 815-822, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30206366

19.

Targeting MAPK in recurrent, low-grade serous ovarian cancer.

Blagden, Sarah P.

Lancet ; 399(10324): 499-501, 2022 02 05.

Artigo em Inglês | MEDLINE | ID: mdl-35123677

20.

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.

Hopkins, Thomas G; Mura, Manuela; Al-Ashtal, Hiba A; Lahr, Roni M; Abd-Latip, Normala; Sweeney, Katrina; Lu, Haonan; Weir, Justin; El-Bahrawy, Mona; Steel, Jennifer H; Ghaem-Maghami, Sadaf; Aboagye, Eric O; Berman, Andrea J; Blagden, Sarah P.

Nucleic Acids Res ; 44(3): 1227-46, 2016 Feb 18.

Artigo em Inglês | MEDLINE | ID: mdl-26717985

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