A new high affinity variant Hb Aurillac (ß141Leu→Val).

Hemoglobin (Hb) variant ß141(H19)Leu→Val (HBB:c.424C>G), one of the two mutations defining Hb Kochi [the other one being ß144(HC1)Lys-Tyr-His→0 (HBB:c.433A>T)], was found as an isolated mutation. In contrast to what was suggested for Hb Kochi, the new variant was not clinically silent. It displayed increased oxygen affinity and was associated with mild erythrocytosis.