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1.
J Med Primatol ; 39(5): 315-7, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20444002

RESUMO

BACKGROUND: A 9-year-old, male castrate, Rhesus macaque was euthanized following a prolonged history of chronic renal failure. RESULTS: Necropsy revealed a proliferative lesion within the right cardiac auricle composed of neoplastic epithelioid cells which infiltrated the myocardium and frequently exhibited intracytoplasmic luminae. Cells multifocally exhibited strong cytoplasmic immunoreactivity for Factor VIII-related protein (von Willebrand's factor). CONCLUSIONS: The histological characteristics of this tumor are consistent with a diagnosis of epithelioid hemangioendothelioma, an intermediate-grade vasoformative neoplasm which has to our knowledge not previously been reported in the heart of a non-human species.


Assuntos
Neoplasias Cardíacas/veterinária , Hemangioendotelioma Epitelioide/veterinária , Macaca mulatta , Doenças dos Macacos/patologia , Animais , Átrios do Coração/patologia , Neoplasias Cardíacas/patologia , Hemangioendotelioma Epitelioide/patologia , Masculino
2.
J Comp Pathol ; 125(4): 254-61, 2001 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11798242

RESUMO

Balloon cell melanoma, a variant of malignant melanoma, has been reported on rare occasions in animals and is uncommon in man. Such tumours have variable numbers of large, round to polygonal cells with abundant, clear, often vacuolated cytoplasm containing fine melanin granules and variable amounts of lipid. This report describes balloon cell melanomas in three dogs. Immunohistochemically, these tumours showed reactions similar to those of human melanomas when tested with antibodies against S-100 protein, neuron-specific enolase (NSE) and vimentin. Electron microscopically, numerous heterogeneous melanosomes were demonstrated in the balloon cell cytoplasm of one tumour. Although balloon cell melanoma apparently occurs infrequently in dogs, it should always be considered in the differential diagnosis of neoplasms containing clear cells.


Assuntos
Doenças do Cão/patologia , Melanoma/veterinária , Neoplasias de Tecidos Moles/veterinária , Animais , Biomarcadores Tumorais/análise , Cães , Feminino , Técnicas Imunoenzimáticas , Masculino , Melanoma/química , Melanoma/patologia , Melanossomas/ultraestrutura , Fosfopiruvato Hidratase/análise , Proteínas S100/análise , Neoplasias de Tecidos Moles/química , Neoplasias de Tecidos Moles/patologia , Vimentina/análise
3.
J Comp Pathol ; 121(2): 179-84, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10405310

RESUMO

This paper describes acute visceral and neural sarcocystosis in four dogs. One animal was simultaneously infected with distemper virus, and another with Blastomyces dermatitidis. Schizonts and merozoites of Sarcocystis canis were found in the lesions. 1999 W.B. Saunders and Company Ltd.


Assuntos
Encéfalo/parasitologia , Doenças do Cão/parasitologia , Sarcocistose/veterinária , Vísceras/parasitologia , Animais , Blastomicose/complicações , Blastomicose/veterinária , Comorbidade , Cinomose/complicações , Cães , Evolução Fatal , Feminino , Masculino , Sarcocystis/isolamento & purificação , Sarcocistose/complicações , Sarcocistose/patologia
4.
J Wildl Dis ; 37(2): 297-305, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11310880

RESUMO

Two immature female bottlenose dolphins (Tursiops truncatus) were found stranded on the Atlantic coast of the USA. Necropsy and histopathologic examination of both dolphins demonstrated acute necrotizing lesions in multiple organ systems. Commonly seen in these lesions were cells with enlarged nuclei that contained single 4 to 6 microm diameter homogeneous eosinophilic inclusion bodies that were often surrounded by a clear halo. Ultrastructural examination revealed that intranuclear inclusions contained 90 to 110 nm diameter viral particles with electron-dense cores and hexagonal profiles. Viral particles were also present in the cytoplasm, and these were surrounded by variably electron-dense envelopes. Enveloped virions were 140 nm in diameter. Polymerase chain reactions targeting the DNA polymerase and terminase genes of herpesviruses were carried out on unfixed tissues of both animals, and analysis of the DNA products indicated the presence of two novel alphaherpesviruses. The gross, histologic, ultrastructural, and molecular genetic findings indicate disseminated herpesviral infections, and support the conclusion that the alphaherpesviruses caused the deaths of the two dolphins. This is the first report of disseminated herpesviral infection in cetaceans.


Assuntos
Alphaherpesvirinae/isolamento & purificação , Golfinhos/virologia , Infecções por Herpesviridae/veterinária , Sequência de Aminoácidos , Doenças dos Animais/patologia , Doenças dos Animais/virologia , Animais , Sequência de Bases , DNA Polimerase Dirigida por DNA/química , Feminino , Infecções por Herpesviridae/patologia , Microscopia Eletrônica/veterinária , Dados de Sequência Molecular , Necrose , Filogenia , Reação em Cadeia da Polimerase/veterinária
6.
Vet Pathol ; 38(2): 165-72, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11280372

RESUMO

Formalin-fixed paraffin-embedded archival tissues of seven adult cats of both sexes that died after being experimentally infected with Yersinia pestis were examined light microscopically to characterize the lesions. The cats were exposed in two groups using two routes of infection: ingestion of Y. pestis-infected rodent or a subcutaneous injection of Y. pestis to simulate a flea bite. Immunohistochemistry was performed on tissues from all organ systems from a representative cat from each group to determine the distribution of Y. pestis bacilli during infection. In all seven cats, bubonic plague lesions were seen. The lesions of pneumonic plague were present in two cats. Septicemic plague was confirmed in all seven cats by bacteriologic culture. Aggregations of bacteria were seen in lymphoid tissue in all cats and in lung tissues from the two cats with pneumonic plague. The most consistent histologic finding was necrosuppurative inflammation in the lymph nodes. Invariably, Y. pestis bacteria were present in large numbers at affected sites. Orally infected cats had more numerous lesions in the lymph nodes of the head and neck regions. These experimentally induced cases of feline plague document that cats are unique among carnivores in exhibiting bubonic, pneumonic, and septicemic plague following exposure to Y. pestis. The lesions of the orally infected cats were consistent with those previously described for naturally occurring Y. pestis infections in cats and corroborate the contention that cats most commonly contract plague by eating Y. pestis-infected rodents and not via flea bite. The histopathology of Y. pestis disease in these cats is comparable to that described for human plague.


Assuntos
Doenças do Gato/patologia , Peste/veterinária , Yersinia pestis/crescimento & desenvolvimento , Animais , Doenças do Gato/microbiologia , Gatos , Feminino , Imuno-Histoquímica/veterinária , Pulmão/patologia , Linfonodos/microbiologia , Linfonodos/patologia , Masculino , Camundongos , Tonsila Palatina/patologia , Peste/microbiologia , Peste/patologia , Sepse/veterinária
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