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2.
Comp Med ; 56(5): 435-8, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17069029

RESUMO

Among 585 sentinel ICR mice (Mus musculus), 8 (7 female, 1 male) had unusual microscopic lesions in the kidney. Light microscopy revealed occasional tubular epithelial cells with large, karyomegalic nuclei that contained intranuclear inclusions and marginated chromatin. These cells were randomly present in the cortex and medulla but were more prominent near the corticomedullary junc tion. Rare pyknotic cells and mild interstitial infiltrates of lymphocytes and plasma cells were associated with occasional foci of abnormal cells. Electron microscopy performed on 2 (1 female, 1 male) of the mice demonstrated intranuclear inclusions composed of abundant flocculent, electron-lucent material. No viral particles or other pathogens were identified. General health monitoring that included serology, microbiology, parasitology, necropsy, and histopathology was negative for pathogens. Polymerase chain reaction-based testing for polyomavirus and immunohistochemistry for adenovirus were performed on 5 of the 7 female mice; all were negative for both viruses. In light of microscopy findings and the lack of evidence for an infectious agent, the tubular lesions were considered degenerative changes, possibly due to a toxic insult. The cause and significance of the findings in these mice can not be explained fully.


Assuntos
Núcleo Celular/ultraestrutura , Corpos de Inclusão Intranuclear/ultraestrutura , Nefropatias/veterinária , Túbulos Renais/ultraestrutura , Camundongos Endogâmicos ICR , Doenças dos Roedores/patologia , Animais , Cromatina/ultraestrutura , Feminino , Nefropatias/patologia , Túbulos Renais/virologia , Masculino , Camundongos , Reação em Cadeia da Polimerase , Vigilância de Evento Sentinela/veterinária , Testes Sorológicos
3.
J Med Primatol ; 37(6): 261-70, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19017193

RESUMO

BACKGROUND: In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years. METHODS: We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants. RESULTS: Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features. CONCLUSION: Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms.


Assuntos
Doenças dos Macacos/patologia , Mixoma/veterinária , Papio , Neoplasias Pélvicas/veterinária , Períneo/patologia , Animais , Feminino , Imuno-Histoquímica/veterinária , Microscopia Eletrônica/veterinária , Mixoma/patologia , Mixoma/ultraestrutura , Neoplasias Pélvicas/patologia , Neoplasias Pélvicas/ultraestrutura , Estudos Retrospectivos
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