Detalhe da pesquisa
1.
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Nature
; 546(7658): 376-380, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28562588
2.
A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'-C-Methylguanosine for the Treatment of Dengue Virus Infection.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32958712
3.
Discovery of Dengue Virus NS4B Inhibitors.
J Virol
; 89(16): 8233-44, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26018165
4.
Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 26(19): 4729-4734, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27575470
5.
Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.
Antimicrob Agents Chemother
; 59(2): 1200-10, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25487807
6.
Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir.
J Virol
; 88(3): 1740-7, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24257621
7.
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 25(17): 3575-81, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26199119
8.
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Bioorg Med Chem Lett
; 23(13): 3741-8, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23726034
9.
The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.
Bioorg Med Chem
; 21(11): 3231-9, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23611771
10.
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
J Med Chem
; 65(12): 8345-8379, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500094
11.
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Sci Transl Med
; 13(579)2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536278
12.
Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors.
Bioorg Med Chem Lett
; 20(8): 2609-13, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20231096
13.
2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors.
Bioorg Med Chem Lett
; 20(5): 1724-7, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20138510
14.
Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
Bioorg Med Chem Lett
; 19(19): 5746-52, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19726184
15.
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.
Bioorg Med Chem Lett
; 18(1): 262-6, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18023344
16.
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Bioorg Med Chem Lett
; 18(1): 256-61, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17998160
17.
Optimised method to estimate octanol water distribution coefficient (logD) in a high throughput format.
Eur J Pharm Sci
; 92: 110-6, 2016 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27373604
18.
Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.
Curr Comput Aided Drug Des
; 12(1): 52-61, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26777113
19.
Direct inhibitors of InhA are active against Mycobacterium tuberculosis.
Sci Transl Med
; 7(269): 269ra3, 2015 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25568071
20.
Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.
ACS Med Chem Lett
; 6(3): 344-8, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25878766