Detalhe da pesquisa
1.
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
J Virol
; 97(10): e0072223, 2023 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37754761
2.
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Hepatology
; 78(4): 1252-1265, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37102495
3.
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Int J Mol Sci
; 24(22)2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003463
4.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
5.
Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans.
J Antimicrob Chemother
; 74(2): 442-452, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30376079
6.
Short-Duration AL-335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis.
Hepatology
; 68(6): 2145-2157, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30070722
7.
Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study.
N Engl J Med
; 373(21): 2048-58, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26580997
8.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098424
9.
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Antiviral Res
; 224: 105835, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401714
10.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
mBio
; 14(1): e0281522, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625640
11.
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
Mol Ther Nucleic Acids
; 27: 335-348, 2022 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024245
12.
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Antiviral Res
; 187: 105020, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515606
13.
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry.
Antiviral Res
; 182: 104924, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32896566
14.
Regulation of gene transcription by thyroid hormone receptor ß agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
PLoS One
; 15(12): e0240338, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33306682
15.
Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227).
Antimicrob Agents Chemother
; 52(12): 4432-41, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18824605
16.
Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells.
Biochem Biophys Res Commun
; 371(1): 110-3, 2008 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18406349
17.
Prophylactic and therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with interferon alfacon-1.
Antiviral Res
; 77(3): 215-24, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18222548
18.
Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma.
J Gastroenterol Hepatol
; 23(10): 1541-8, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18422961
19.
Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.
PLoS One
; 13(10): e0204974, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30325939
20.
Comparison of the inhibitory effects of interferon alfacon-1 and ribavirin on yellow fever virus infection in a hamster model.
Antiviral Res
; 73(2): 140-6, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17049380