Detalhe da pesquisa
1.
Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver.
Toxicol Pathol
; 51(7-8): 470-481, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-38288963
2.
Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers.
Int J Mol Sci
; 22(23)2021 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34884436
3.
Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective.
Regul Toxicol Pharmacol
; 96: 18-29, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29679677
4.
Toxicology Strategies for Drug Discovery: Present and Future.
Chem Res Toxicol
; 29(4): 473-504, 2016 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26588328
5.
Transcriptomic evaluation of canine suspension-shipped and pre-plated hepatocytes: comparison to liver.
Toxicol Mech Methods
; 23(7): 479-90, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23581556
6.
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects.
J Pharmacol Toxicol Methods
; 123: 107468, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37553032
7.
Preclinical species gene expression database: Development and meta-analysis.
Front Genet
; 13: 1078050, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36733943
8.
Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats.
Arch Toxicol
; 85(5): 513-23, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21046364
9.
Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals.
Int J Mol Sci
; 12(4): 2502-17, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21731455
10.
Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example.
Int J Mol Sci
; 11(11): 4697-714, 2010 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21151465
11.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Nat Rev Drug Discov
; 19(2): 131-148, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31748707
12.
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development.
Toxicol Lett
; 186(1): 22-31, 2009 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18996174
13.
Novel Computational Approach to Predict Off-Target Interactions for Small Molecules.
Front Big Data
; 2: 25, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-33693348
14.
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.
J Pharmacol Exp Ther
; 327(3): 634-44, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18801949
15.
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
J Pharmacol Exp Ther
; 324(2): 507-16, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18025247
16.
Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells.
Drug Metab Dispos
; 36(2): 223-33, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17967932
17.
A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
Drug Metab Dispos
; 36(3): 500-7, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18096673
18.
Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist.
Neurosci Res
; 60(3): 266-74, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18164502
19.
Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology.
Methods Mol Biol
; 460: 23-44, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18449481
20.
Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats.
Toxicol Lett
; 176(2): 138-48, 2008 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18164877