Major depressive disorder and immunity. Role of age, sex, severity, and hospitalization.

An association between depression and altered immunity has been suggested but has not been consistently demonstrated. We have studied 91 patients with unipolar major depressive disorder, and no mean differences were found between the patients and concurrently studied matched controls in mitogen-induced lymphocyte proliferation, lymphocyte subsets, and natural killer cell activity. There were, however, significant age-related differences between the depressed patients and controls in mitogen responses and in the number of T4 lymphocytes. In contrast to age-related increases in mitogen response and in T4 cells in controls, depressed patients did not show increased lymphocyte responses or numbers of T4 lymphocytes with advancing age. Severity of depression and hospitalization status were also associated with immune system changes. Altered immunity does not appear to be a specific biologic correlate of major depressive disorder but may occur in subgroups of depressed patients.

Effects of prenatal exposure to neuroleptic drugs on children's growth.

The effect of prenatal exposure to neuroleptic drugs on height and weight from birth to 7 years was examined in children of psychiatrically normal parents and of parents with a history of psychiatric treatment, using data from the Collaborative Perinatal Project of the National Institute of Neurological Diseases, Communicative Disorders, and Stroke. Analysis of covariance was used to control for potential confounding factors. We found that prenatal exposure to dopamine receptor-blocking neuroleptic drugs was associated with increased height in one or more of our groups at 4 months, 1 year, and 7 years and less consistently with increased weight. Seven-year-old children who had been exposed to these drugs for more than 2 months during gestation were approximately 3 cm taller than unexposed controls (p less than 0.05). Prenatal exposure to dopamine-depleting agents was associated with decreased height at 4 months but not later. Possible mechanisms for these effects, including a permanent decrease in the number of brain dopamine receptors and effects on various hormones, are discussed.

An automated system for the analyses of temporal speech patterns: description of the hardware and software.

A system (WELMAR II) is described for analyzing time patterns of speech on small computers. Temporal speech patterning refers to the pacing of the sounds and silences that make up a stream of speech. The system is particularly useful for research involving clinical populations since it has been shown that speech rhythms are sensitive to interpersonal influence, to dimensions of personality, and to psychological pathology.

Acoustical correlates of the perception of speech rate: an experimental investigation.

The purpose of the study was to investigate the influence of vocal frequency and vocal intensity upon the perception of speech rate at three levels of actual speech rate. A single sample of spontaneous speech was electronically varied to produce nine stimulus segments that factorially combined three levels each of vocal frequency and intensity. The nine stimuli were recorded such that preceding each was the original segment that served as the standard with which each of the nine stimuli was to be compared. The speech rate of the set of nine stimulus pairs was then electronically altered to obtain a slow set, a moderate set, and a fast set, although the duration of every segment in the three sets was 20 seconds. The sets were rated by different groups of judges in terms of four 7-point scales that measured perceived speech rate, pitch, loudness, and perceived duration. The results indicate that the perception of speech rate is positively related to vocal frequency and intensity at each of the three actual speech rates, and suggest that these relationships are a function of the repeated experience of almost always hearing such covariation in spontaneously occurring speech.

The Depressive Experiences Questionnaire: revision and validation.

The present study presents a new, unit-weight scoring system for the Depressive Experiences Questionnaire (DEQ). One hundred thirty-one college students completed the DEQ, the Bem Sex-Role Inventory (BSRI), and the Beck Depression Inventory (BDI). The revised DEQ scales were shown to have substantial levels of internal consistency. The three subscales of the revised DEQ were significantly correlated with the BSRI masculinity and femininity scales but not with gender. Significant correlations were also obtained between DEQ anaclitic, DEQ introjective scales and the BDI.

Conversational time patterns and mutual influence in parent-child interactions: a time series approach.

Mutual influencing processes are assumed to be the basic building blocks in establishing parent-child bonding and in influencing cognitive and language behavior. A study by Jasnow and Feldstein (1986) revealed that, within the temporal domain of speech, preverbal (9-month-old) infants and their mothers exhibit a pattern of mutual influence (attunement) in their average durations of switching pauses. The general purpose of this research was to extend those findings to children with higher verbal functioning. In addition, parent and child genders, nature of the interaction, and specific aspects of parents' personalities, expressiveness, and instrumentality were considered. Each parent interacted with their 4- or 5-year-old son or daughter in each of two conversations--unstructured (social conversation) and structured (task activity). Conversations were processed by an automated computer system yielding objective measure of turns, vocalizations, pauses, and switching-pause durations. To examine interspeaker influence of attunement of temporal speech patterns, "influence coefficients" were computer for each speaker on a "turn-by-turn" basis using time series regression. Analysis of these coefficients revealed that: (1) Mutual influence is most evident with switching-pause duration. (2) Structure in the conversation (as defined by the task or parental instrumentality) seems to facilitate attunement for vocalization and switching pause duration. (3) Attunement with girls seems to occur equally well with both parents, while boys exhibit a style of temporal patterning influence which suggests greater identification with the father. (4) Expressiveness seems to facilitate attunement to the child's switching-pause duration.

Vocal cues to deception: a comparative channel approach.

The study investigated the leakage potential of different voice and speech cues using a cue isolation and masking design. Speech samples taken from an earlier experiment were used in which 15 female students of nursing dissimulated negative affect produced by an unpleasant movie or told the truth about positive affect following a pleasant movie. Several groups of judges rated these speech samples in five conditions: (1) forward or clear, (2) electronic filtering, (3) random splicing, (4) backwards, (5) pitch inversion, (6) tone-silence sequences. The results show that vocal cues do indeed carry leakage information and that, as reflected in the differences among the conditions masking different types of cues respectively, voice quality cues may be centrally implicated. In addition, gender differences in decoding ability are discussed.

Toward greater understanding of depression in deaf individuals.

We compared the prevalence of depressive symptoms among deaf and hearing college students and examined the relationships among depressive symptoms, personality characteristics, and perceived parental attitudes and behaviors in these two groups. Measures were revised to meet the language needs of the deaf subjects. Mild levels of depressive symptoms were more prevalent in the deaf than in the hearing students, but more severe depression was not. In both groups, depressive symptoms were associated with perceptions of lower maternal care and higher maternal over-protection. Deaf and hearing subjects did not differ on these perceived maternal characteristics. Depressive symptoms were associated with socially dependent personality characteristics in the hearing sample only. We discuss the implications of the findings for the role of personality development in depression in deaf individuals.

Stress-induced alterations of immunity in hypophysectomized rats.

Stress-induced suppression of mitogen-induced lymphocyte proliferation was demonstrated in hypophysectomized rats. Stress effects on the numbers of peripheral blood lymphocytes and lymphocyte subsets and on splenic natural killer cell activity require the presence of pituitary. A pituitary-dependent restraining influence on stress-induced alteration of immunity is described. These results indicate that stress-induced modulation of immunity is complex and includes a range of enhancing and inhibitory mechanisms.