Detalhe da pesquisa
1.
Small-molecule IKKß activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Proc Natl Acad Sci U S A
; 119(18): e2115071119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476515
2.
The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis.
J Biol Chem
; 299(1): 102762, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36463962
3.
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies.
Bioorg Med Chem Lett
; 94: 129465, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37669721
4.
A simple fluorescent assay for the discovery of protein-protein interaction inhibitors.
Anal Biochem
; 569: 46-52, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30707898
5.
Substrate-analog binding and electrostatic surfaces of human manganese superoxide dismutase.
J Struct Biol
; 199(1): 68-75, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461152
6.
Characterizing pathological imperfections in macromolecular crystals: lattice disorders and modulations.
Crystallogr Rev
; 26(1): 3-50, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33041501
7.
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.
Biochim Biophys Acta
; 1833(1): 122-39, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23085373
8.
The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break Repair.
Genes (Basel)
; 15(2)2024 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38397158
9.
Structural Insight into Geranylgeranyl Diphosphate Synthase (GGDPS) for Cancer Therapy.
Mol Cancer Ther
; 23(1): 14-23, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37756579
10.
Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Res Sq
; 2024 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38405788
11.
Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
bioRxiv
; 2024 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38328249
12.
The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core.
J Struct Biol
; 182(3): 197-208, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23528839
13.
Simulation of modulated protein crystal structure and diffraction data in a supercell and in superspace.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 6): 1062-72, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23695251
14.
ITPA (inosine triphosphate pyrophosphatase): from surveillance of nucleotide pools to human disease and pharmacogenetics.
Mutat Res
; 753(2): 131-146, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23969025
15.
The structure and function of replication protein A in DNA replication.
Subcell Biochem
; 62: 171-96, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22918586
16.
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies.
bioRxiv
; 2023 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37090570
17.
Perfect Crystals: microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography.
NPJ Microgravity
; 9(1): 39, 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270576
18.
A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral and Cellular Immune Responses and Protects Mice from Lethal Virus Challenge.
Vaccines (Basel)
; 11(4)2023 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37112733
19.
Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction.
Acta Crystallogr F Struct Biol Commun
; 78(Pt 1): 8-16, 2022 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34981770
20.
Replication Protein A Phosphorylation Facilitates RAD52-Dependent Homologous Recombination in BRCA-Deficient Cells.
Mol Cell Biol
; 42(2): e0052421, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34928169