Detalhe da pesquisa
1.
Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell
; 168(5): 878-889.e29, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235199
2.
AutoDesigner, a De Novo Design Algorithm for Rapidly Exploring Large Chemical Space for Lead Optimization: Application to the Design and Synthesis of d-Amino Acid Oxidase Inhibitors.
J Chem Inf Model
; 62(8): 1905-1915, 2022 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35417149
3.
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation.
Nat Chem Biol
; 14(5): 507-515, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29610484
4.
Combining Cloud-Based Free-Energy Calculations, Synthetically Aware Enumerations, and Goal-Directed Generative Machine Learning for Rapid Large-Scale Chemical Exploration and Optimization.
J Chem Inf Model
; 60(9): 4311-4325, 2020 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32484669
5.
K-RasG12D Has a Potential Allosteric Small Molecule Binding Site.
Biochemistry
; 58(21): 2542-2554, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31042025
6.
Reaction-Based Enumeration, Active Learning, and Free Energy Calculations To Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-Dependent Kinase 2 Inhibitors.
J Chem Inf Model
; 59(9): 3782-3793, 2019 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31404495
7.
Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity.
J Am Chem Soc
; 135(47): 17978-82, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24161069
8.
Asymmetric allylic alkylation of acyclic allylic ethers with organolithium reagents.
Chemistry
; 18(38): 11880-3, 2012 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22907628
9.
Catalytic asymmetric conjugate addition of dialkylzinc reagents to alpha,beta-unsaturated sulfones.
Org Biomol Chem
; 8(1): 47-9, 2010 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20024129
10.
Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents.
Cell Chem Biol
; 26(12): 1703-1715.e37, 2019 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31676236
11.
Stereoselective synthesis of 2,3,7-trimethylcyclooctanone and related compounds and determination of their relative and absolute configurations by the MalphaNP acid method.
Chirality
; 20(9): 1053-65, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18655174
12.
Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.
Cell Chem Biol
; 25(5): 585-594.e7, 2018 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29576531
13.
Enantioselective synthesis of tertiary and quaternary stereogenic centers: copper/phosphoramidite-catalyzed allylic alkylation with organolithium reagents.
Angew Chem Int Ed Engl
; 51(8): 1922-5, 2012 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22262571
14.
Cu-catalyzed enantioselective allylic alkylation with organolithium reagents.
Nat Protoc
; 12(3): 493-505, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28151465
15.
Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine.
Org Lett
; 19(19): 5150-5153, 2017 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28876074
16.
Catalytic asymmetric conjugate addition/oxidative dearomatization towards multifunctional spirocyclic compounds.
Angew Chem Int Ed Engl
; 50(26): 5834-8, 2011 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21567700
17.
Catalyst-controlled reverse selectivity in C-C bond formation: NHC-Cu-catalyzed α-selective allylic alkylation with organolithium reagents.
Chem Commun (Camb)
; 51(38): 8142-5, 2015 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25872468
18.
Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with organolithium reagents.
Chem Commun (Camb)
; 48(12): 1748-50, 2012 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22215200
19.
Catalytic asymmetric carbon-carbon bond formation via allylic alkylations with organolithium compounds.
Nat Chem
; 3(5): 377-81, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21505496
20.
Catalytic asymmetric conjugate addition of grignard reagents to alpha,beta-unsaturated sulfones.
Org Lett
; 10(19): 4219-22, 2008 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18767856