[The long-term sequelae of the effect of incorporated radioactive iodine on the endocrine system in an endemic locality-]. / Viddaleni naslidky vplyvu inkorporovannoho radioaktyvnoho iodu na endokrynnu systemu v umovakh endemichnoï mistsevosti.

25-30 years after the 131J therapeutic dose intake the function of the thyroid gland was found to get impaired in 18% of those irradiated, with the diabetes mellitus incidence rate tending to be on the increase almost two-fold. 131J did not have apparent suppressive action on sexual glands and adrenals. In those persons having taken 131J, frequency of the thyroid gland neoplasia gets increased almost 6-fold as compared to general population.

[The morbidity indices of subjects with incorporated radioactive iodine]. / Pokaznyky zakhvoriuvanosti u osib z inkorporovanym radioaktyvnym iodom.

With the purpose of detecting long-term somatic effects of incorporated iodine, an analysis was performed of health disorders in those subjects (n = 1040) who received 131 I in therapeutic dosages 25 to 30 years ago. Discordances in pituitary-thyroid- and pituitary-adrenal axes were found to result in excessive metabolic-degenerative and vegetovascular type morbidity rates compared with the general population. Mortality index exceeds that of in the population 2.1-fold. No one of the deceased had reached the average length of human life. Halt the cases died of ischemic heart disease, 6 patients developed carcinoma of endocrine organs; these were all females, who had taken radioactive iodine prior to the age of 30 years. Thus, in remote time periods after incorporation, there develop a number of those disorders leading ultimately to reduction of the length of human life, which is believed to be one of the universal effects of irradiation.

[Immunity and the prostaglandin level in gastritis B]. / Sostoianie immuniteta i uroven' prostaglandinov pri gastrite B.

The indices of systemic and local immunity, level of prostaglandins, presence of Helicobacter pylori in the gastric mucosa was studied in 53 patients with gastritis B. Patients with superficial antral gastritis showed independent of the presence of Helicobacter pylori in the gastric mucosa changes of the systemic immunity and level of PGE2 and PGF1 that were abnormal. In atrophy of the antral gastric mucosa and presence there of H. pylori one observed a reduction of the number of T-lymphocytes and proliferative activity. Suppression of the system of prostaglandins in the blood and gastric mucosa, the toxic effect of H. pylori results in autosensibilization, increase of IgA and IgG finally leading to development of erosions in the gastric antrum.