Detalhe da pesquisa
1.
Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells.
Drug Metab Dispos
; 44(1): 50-60, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26467767
2.
Physiologically based pharmacokinetic modeling for sequential metabolism: effect of CYP2C19 genetic polymorphism on clopidogrel and clopidogrel active metabolite pharmacokinetics.
Drug Metab Dispos
; 43(4): 510-22, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25609219
3.
PBPK modeling of irbesartan: incorporation of hepatic uptake.
Biopharm Drug Dispos
; 36(8): 491-506, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26037524
4.
Optimization of the Antibacterial Spectrum and the Developability Profile of the Novel-Class Natural Product Corramycin.
J Med Chem
; 66(24): 16869-16887, 2023 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38088830
5.
Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite.
Drug Metab Dispos
; 40(1): 187-97, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22004687
6.
Metabolic-based drug-drug interactions prediction, recent approaches for risk assessment along drug development.
Drug Metabol Drug Interact
; 26(4): 147-68, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22149659
7.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Sci Transl Med
; 13(603)2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290058
8.
Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A.
Br J Clin Pharmacol
; 68(6): 928-35, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20002088
9.
Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding.
J Pharm Sci
; 107(7): 1957-1972, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29524447
10.
Quantitative correlations among CYP3A sensitive substrates and inhibitors: literature analysis.
Curr Drug Metab
; 8(8): 810-4, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18220561
11.
IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds.
Eur J Pharm Sci
; 96: 598-609, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671970
12.
CYP3A4-based drug-drug interaction: CYP3A4 substrates' pharmacokinetic properties and ketoconazole dose regimen effect.
Eur J Drug Metab Pharmacokinet
; 41(1): 45-54, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25374256
13.
Clopidogrel pharmacodynamics and pharmacokinetics in the fed and fasted state: a randomized crossover study of healthy men.
J Clin Pharmacol
; 52(10): 1506-15, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22128201